ITPR3 Antibody

Code CSB-PA852295
Size US$166
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA852295(ITPR3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA852295(ITPR3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
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Product Details

Uniprot No.
Target Names
Alternative Names
4 antibody; 5-trisphosphate receptor antibody; 5-trisphosphate receptor type 3 antibody; FLJ36205 antibody; Inositol 1 antibody; Inositol 1,4,5 trisphosphate receptor type 3 antibody; InsP3R3 antibody; IP3 receptor antibody; IP3 receptor isoform 3 antibody; IP3R 3 antibody; IP3R antibody; IP3R3 antibody; ITPR 3 antibody; ITPR3 antibody; ITPR3_HUMAN antibody; Type 3 inositol 1 antibody; Type 3 inositol 1,4,5 trisphosphate receptor antibody; Type 3 InsP3 receptor antibody
Raised in
Species Reactivity
Synthetic peptide of Human ITPR3
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen affinity purification
It differs from different batches. Please contact us to confirm it.
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
IHC 1:50-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Gene References into Functions
  1. Data demonstrated that IP3R3 is able to modulate intracellular Ca(2+) availability and to coordinate the remodeling of profilin cytoskeleton organization through the ARHGAP18/RhoA/mDia1/FAK pathway. PMID: 29630900
  2. Suggest that AT haplotype in the ITPR3 gene may serve as a potential marker for genetic susceptibility to cervical squamous cell carcinoma risk in Taiwanese women. PMID: 28036301
  3. PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
  4. BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation PMID: 28614305
  5. The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion. PMID: 25796361
  6. miR-506 is a regulator of InsP3R3 expression and InsP3R3-mediated Ca2+ signaling and secretion. PMID: 25378392
  7. It mediate calcium release from intracellular calcium stores such as the ER into the cytoplasm. (review) PMID: 24285081
  8. Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3 receptors. PMID: 24469450
  9. A molecular and functional link between BKCa channel and IP3R3 in cancer cells as an important mechanism for tumor cell proliferation. PMID: 23992640
  10. in human pulmonary fibroblasts, PDGF acts through IP3-induced Ca(2+)-release to trigger Ca(2+) waves, which in turn modulate gene expression of several matrix proteins. PMID: 23618877
  11. The presence of isoform III of inositol 1,4,5-trisphosphate receptor is the key point of Akt activity on calcium-mediated apoptosis. PMID: 22552281
  12. Ins(1,4,5)P3R-mediated Ca2+ signaling was critical for starvation-induced autophagy stimulation. PMID: 22082873
  13. The study provides biochemical evidence of the interaction between FKBP12 and RYR1, RYR3 and IP3R. PMID: 22100703
  14. the critical region of KRAP protein for the regulation of IP(3)R was determined. PMID: 21501587
  15. results of this study suggest that the rs2229634 SNP in the ITPR3 gene is associated with the risk of coronary artery aneurysm formation in Taiwanese Kawasaki disease patients PMID: 20618519
  16. inositol 145-triphosphate receptor type 3 becomes expressed in colon cancer, and its expression level is directly related to aggressiveness of the tumor PMID: 21075448
  17. Findings suggest IP(3)R3 as a novel therapeutic target and identify caffeine as a possible adjunct therapy to slow invasive growth of glioblastoma. PMID: 20103623
  18. IP3R3 may be a prerequisite for secretion of an enzyme, such as protease, in gastric cancer cells; results indicate that IP3R3 may be specifically involved in gastric cancer peritoneal dissemination PMID: 14666665
  19. The estimated population-attributable risk of 21.6% suggests that variation within ITPR3 reflects an important contribution to type 1 diabetes in Sweden. PMID: 16960798
  20. Anti-IP(3)R1 antibodies were present in 48.6% of primary Sjogren's syndrome and in 3.0% of normal healthy subjects. PMID: 17437169
  21. IP3R3 is present in the paranodal regions of the nodes in the sciatic nerve. PMID: 17496801
  22. A functional single nucleotide polymorphism in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus PMID: 18219441
  23. the ankyrin-binding site is located on the cytoplasmic face of the InsP(3) receptor, thus validating the feasibility of in vivo ankyrin-InsP(3) receptor interactions. PMID: 18275062
  24. The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II. PMID: 18340361
  25. In this review, by sensing sequential binding of IP3 and calcium ions, the IP3 receptor acts as a coincidence detector that associates parallel fiber inputs with climbing fiber inputs. PMID: 18434505
  26. sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593
  27. the agonist-induced clustering of IP(3)R is triggered by IP(3) binding, rather than [Ca(2+)](i) elevation. PMID: 18544901
  28. May play a role in calcium-dependent nuclear processes. PMID: 18586264
  29. IP3-mediated sensitization requires IP3 receptor binding to a TRPV4 C-terminal domain that overlaps with a previously described calmodulin-binding site PMID: 18826956
  30. Inability of the T-cell receptors in TCR transgenic mice to trigger calcium mobilization may be due to the insufficient level of inositol 1,4,5-triphosphate receptor (IP3) type 3 to initiate the release of calcium from intracellular stores. PMID: 19050248
  31. Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. PMID: 19052258
  32. Results demonstrate the importance of the InsP3 receptor-mutant huntingtin protein association for the pathogenesis of Huntington's disease and as a potential therapeutic target for Huntington's disease. PMID: 19193873
  33. Data show that the BH4 domain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor on the endoplasmic reticulum. PMID: 19706527

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Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
InsP3 receptor family
Tissue Specificity
Expressed in intestinal crypt and villus epithelial cells.
Database Links

HGNC: 6182

OMIM: 147267

KEGG: hsa:3710

STRING: 9606.ENSP00000363435

UniGene: Hs.65758

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