Recombinant Human Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3), partial

1. Data demonstrated that IP3R3 is able to modulate intracellular Ca(2+) availability and to coordinate the remodeling of profilin cytoskeleton organization through the ARHGAP18/RhoA/mDia1/FAK pathway. PMID: 29630900
2. Suggest that AT haplotype in the ITPR3 gene may serve as a potential marker for genetic susceptibility to cervical squamous cell carcinoma risk in Taiwanese women. PMID: 28036301
3. PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
4. BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation PMID: 28614305
5. The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion. PMID: 25796361
6. miR-506 is a regulator of InsP3R3 expression and InsP3R3-mediated Ca2+ signaling and secretion. PMID: 25378392
7. It mediate calcium release from intracellular calcium stores such as the ER into the cytoplasm. (review) PMID: 24285081
8. Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3 receptors. PMID: 24469450
9. A molecular and functional link between BKCa channel and IP3R3 in cancer cells as an important mechanism for tumor cell proliferation. PMID: 23992640
10. in human pulmonary fibroblasts, PDGF acts through IP3-induced Ca(2+)-release to trigger Ca(2+) waves, which in turn modulate gene expression of several matrix proteins. PMID: 23618877
11. The presence of isoform III of inositol 1,4,5-trisphosphate receptor is the key point of Akt activity on calcium-mediated apoptosis. PMID: 22552281
12. Ins(1,4,5)P3R-mediated Ca2+ signaling was critical for starvation-induced autophagy stimulation. PMID: 22082873
13. The study provides biochemical evidence of the interaction between FKBP12 and RYR1, RYR3 and IP3R. PMID: 22100703
14. the critical region of KRAP protein for the regulation of IP(3)R was determined. PMID: 21501587
15. results of this study suggest that the rs2229634 SNP in the ITPR3 gene is associated with the risk of coronary artery aneurysm formation in Taiwanese Kawasaki disease patients PMID: 20618519
16. inositol 145-triphosphate receptor type 3 becomes expressed in colon cancer, and its expression level is directly related to aggressiveness of the tumor PMID: 21075448
17. Findings suggest IP(3)R3 as a novel therapeutic target and identify caffeine as a possible adjunct therapy to slow invasive growth of glioblastoma. PMID: 20103623
18. IP3R3 may be a prerequisite for secretion of an enzyme, such as protease, in gastric cancer cells; results indicate that IP3R3 may be specifically involved in gastric cancer peritoneal dissemination PMID: 14666665
19. The estimated population-attributable risk of 21.6% suggests that variation within ITPR3 reflects an important contribution to type 1 diabetes in Sweden. PMID: 16960798
20. Anti-IP(3)R1 antibodies were present in 48.6% of primary Sjogren's syndrome and in 3.0% of normal healthy subjects. PMID: 17437169
21. IP3R3 is present in the paranodal regions of the nodes in the sciatic nerve. PMID: 17496801
22. A functional single nucleotide polymorphism in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus PMID: 18219441
23. the ankyrin-binding site is located on the cytoplasmic face of the InsP(3) receptor, thus validating the feasibility of in vivo ankyrin-InsP(3) receptor interactions. PMID: 18275062
24. The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II. PMID: 18340361
25. In this review, by sensing sequential binding of IP3 and calcium ions, the IP3 receptor acts as a coincidence detector that associates parallel fiber inputs with climbing fiber inputs. PMID: 18434505
26. sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593
27. the agonist-induced clustering of IP(3)R is triggered by IP(3) binding, rather than [Ca(2+)](i) elevation. PMID: 18544901
28. May play a role in calcium-dependent nuclear processes. PMID: 18586264
29. IP3-mediated sensitization requires IP3 receptor binding to a TRPV4 C-terminal domain that overlaps with a previously described calmodulin-binding site PMID: 18826956
30. Inability of the T-cell receptors in TCR transgenic mice to trigger calcium mobilization may be due to the insufficient level of inositol 1,4,5-triphosphate receptor (IP3) type 3 to initiate the release of calcium from intracellular stores. PMID: 19050248
31. Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. PMID: 19052258
32. Results demonstrate the importance of the InsP3 receptor-mutant huntingtin protein association for the pathogenesis of Huntington's disease and as a potential therapeutic target for Huntington's disease. PMID: 19193873
33. Data show that the BH4 domain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor on the endoplasmic reticulum. PMID: 19706527

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HGNC: 6182

OMIM: 147267

KEGG: hsa:3710

STRING: 9606.ENSP00000363435

UniGene: Hs.65758