ITPR3 Research Reagents

Inositol 1,4,5-trisphosphate receptor type 3 is a protein in humans that is encoded by ITPR3 gene. Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

The following ITPR3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ITPR3 Antibodies

ITPR3 Antibodies for Homo sapiens (Human)

ITPR3 Proteins

ITPR3 Proteins for Homo sapiens (Human)

ITPR3 Proteins for Rattus norvegicus (Rat)

ITPR3 Proteins for Bos taurus (Bovine)

ITPR3 Background

The ITPR3 gene encodes inositol 1,4,5-trisphosphate receptor type 3, one of intracellular calcium (Ca2+) release channels mediates the calcium signaling [1][2]. The IP3R proteins are structurally and functionally divided into 5 distinct domains: the N-terminal coupling domain (or suppressor domain), the IP3-binding core, the modulatory and transducing domain, the channel domain and the C-terminal coupling domain [3]. Among the three IP3R isoforms, IP3R3 has the lowest affinity for IP3 [4]. The binding of IP3R and IP3R3 redistributes Ca2+ from the ER to cytosol, leading to an increase in the cytosolic Ca2+ concentration [5]. Elevated Ca2+ levels further activates Ca2+-dependent proteins, inducing a cascade of intracellular responses, including cell division, cell proliferation, apoptosis, fertilization, development, behavior, memory, and learning [6]. IP3R3 was shown to correlate with colorectal carcinoma aggressiveness [7], or with increased cell migration capacities [8]. Inhibition of the IP3R3 attenuated breast cancer cell proliferation [9], migration, invasion, and survival of glioblastoma cells [10] and revealed an oscillating Ca2+ signature along with a slowing down cell migration in human breast cancer cells [8]. IP3R3 may also be specifically involved in gastric cancer peritoneal dissemination and these receptors may serve as a molecular target for treatment of this cancer [11]. On the other hand, inhibition of the IP3R3 degradation resulted in sensitization to photodynamic therapy in tumors with no or low levels of phosphatase and tensin homologue (PTEN) expression [12]. Ingeborg Rezuchova et al. clearly proved that in tumor cells of solid tumors, the IP3R3 has anti-apoptotic and proliferative function, on contrary to the IP3R1 and IP3R2 [13].

[1] Yamamoto-Hino M, Sugiyama T, et al. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors [J]. Recept. Channels. 1994, 2 (1): 9-22.
[2] Blondel O, Takeda J, et al. Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues [J]. J Biol Chem. 1993;268:11356-11363.
[3] Bosanac I, Michikawa T, et al. Structural insights into the regulatory mechanism of IP3 receptor [J]. Biochim Biophys Acta. 2004;1742:89-102.
[4] Newton CL, Mignery GA, et al. Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3 [J]. J Biol Chem. 1994;269:28613-28619.
[5] Berridge M.J. Inositol trisphosphate and calcium signalling [J]. Nature. 1993; 361: 315-325.
[6] Furuichi T. and Mikoshiba K. Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain [J]. J. Neurochem. 1995; 64: 953-960.
[7] Shibao, K. et al. The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma [J]. Cell Calcium 2010, 48, 315-323.
[8] Mound, A. et al. Downregulation of type 3 inositol (1,4,5)-trisphosphate receptor decreases breast cancer cell migration through an oscillatory Ca2+ signal [J]. Oncotarget 2017, 8, 72324-72341.
[9] Szatkowski, C., Parys, J. B., Ouadid-Ahidouch, H. & Matifat, F. Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth [J]. Mol. Cancer 2010, 9, 156.
[10] Kang, S. S. et al. Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival [J]. Cancer Res. 2010, 70, 1173-1183.
[11] Sakakura, C. et al. Possible involvement of inositol 1,4,5-trisphosphate receptor type 3 (IP3R3) in the peritoneal dissemination of gastric cancers [J]. Anticancer Res. 2003, 23, 3691-3697.
[12] Kuchay, S. et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth [J]. Nature 2017, 546, 554-558.
[13] Ingeborg Rezuchova, Sona Hudecova, et al. Type 3 inositol 1,4,5-trisphosphate receptor has antiapoptotic and proliferative role in cancer cells [J]. Rezuchova et al. Cell Death and Disease (2019) 10:186.

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