Code | CSB-PA017767LA01HU |
Size | US$299 |
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Description |
PECAM1 polyclonal antibody CSB-PA017767LA01HU was produced in the rabbit immunized by using the Recombinant Human Platelet endothelial cell adhesion molecule protein (525-586AA) as the immunogen. The target protein PECAM1 is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. It is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. Diseases associated with PECAM1 include Angiosarcoma and Capillary Hemangioma.
This Rabbit anti-Homo sapiens (Human) PECAM1 Polyclonal antibody was tested in the ELISA, WB, IHC and IF. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the PECAM1 proteins of human or mouse or rat-origin and may be used to detect the endogenous levels of PECAM1 protein. |
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Full Product Name | Rabbit anti-Homo sapiens (Human) PECAM1 Polyclonal antibody | ||||||||
Uniprot No. | P16284 | ||||||||
Target Names | PECAM1 | ||||||||
Alternative Names | PECAM1; Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD antigen CD31 | ||||||||
Raised in | Rabbit | ||||||||
Species Reactivity | Human, Mouse, Rat | ||||||||
Immunogen | Recombinant Human Platelet endothelial cell adhesion molecule protein (525-586AA) | ||||||||
Immunogen Species | Homo sapiens (Human) | ||||||||
Conjugate | Non-conjugated The PECAM1 Antibody (Product code: CSB-PA017767LA01HU) is Non-conjugated. For PECAM1 Antibody with conjugates, please check the following table. |
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Clonality | Polyclonal | ||||||||
Isotype | IgG | ||||||||
Purification Method | >95%, Protein G purified | ||||||||
Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
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Form | Liquid | ||||||||
Tested Applications | ELISA, WB, IHC, IF | ||||||||
Recommended Dilution |
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Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol |
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Troubleshooting and FAQs | Antibody FAQs | ||||||||
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function |
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis.; Does not protect against apoptosis.
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Gene References into Functions |
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Subcellular Location | Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction.; [Isoform Delta15]: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. |
Tissue Specificity | Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level). Expressed on neutrophils (at protein level). Isoform Long predom |
Database Links |
HGNC: 8823 OMIM: 173445 KEGG: hsa:5175 UniGene: Hs.376675 |