Recombinant Goat Interleukin-12 subunit beta(IL12B)

Product Type Recombinant Protein
Uniprot No. P68221
Species Capra hircus (Goat)
Gene Names IL12B
Protein Names Recommended name: Interleukin-12 subunit beta Short name= IL-12B Alternative name(s): Cytotoxic lymphocyte maturation factor 40 kDa subunit Short name= CLMF p40 IL-12 subunit p40
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
HGNC 5970
RGD 628704
MGI 96540
Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular Location Secreted
Protein Families Type I cytokine receptor family, Type 3 subfamily
Database Links

KEGG: chx:100860845

UniGene: Chi.38710

Pathway Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Toll-like receptor signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Goat Interleukin-12 subunit beta(IL12B),Yeast
Code CSB-YP011587GO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IWELEKNV YVVELDWYPN APGETVVLTC DTPEEDGITW TSDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSRS LLLLHKKEDG IWSTDILKDQ KEPKAKSFLK CEAKDYSGHF TCSWLTAIST NLKFSVKSSR GSSDPRGVTC GAASLSAEKV SMDHREYNKY TVECQEGSAC PAAEESLPIE VVMEAVHKLK YENYTSSFFI RDIIKPDPPK NLQLRPLKNS RQVEVSWEYP DTWSTPHSYF SLTFCVQVQG KNKREKKLFT DQTSAKVTCH KDANIRVQAR DRYYSSFWSE WASVSCS
Expression Region 23-327
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Goat Interleukin-12 subunit beta(IL12B),E.coli
Code CSB-EP011587GO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IWELEKNV YVVELDWYPN APGETVVLTC DTPEEDGITW TSDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSRS LLLLHKKEDG IWSTDILKDQ KEPKAKSFLK CEAKDYSGHF TCSWLTAIST NLKFSVKSSR GSSDPRGVTC GAASLSAEKV SMDHREYNKY TVECQEGSAC PAAEESLPIE VVMEAVHKLK YENYTSSFFI RDIIKPDPPK NLQLRPLKNS RQVEVSWEYP DTWSTPHSYF SLTFCVQVQG KNKREKKLFT DQTSAKVTCH KDANIRVQAR DRYYSSFWSE WASVSCS
Expression Region 23-327
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Goat Interleukin-12 subunit beta(IL12B),Baculovirus
Code CSB-BP011587GO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IWELEKNV YVVELDWYPN APGETVVLTC DTPEEDGITW TSDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSRS LLLLHKKEDG IWSTDILKDQ KEPKAKSFLK CEAKDYSGHF TCSWLTAIST NLKFSVKSSR GSSDPRGVTC GAASLSAEKV SMDHREYNKY TVECQEGSAC PAAEESLPIE VVMEAVHKLK YENYTSSFFI RDIIKPDPPK NLQLRPLKNS RQVEVSWEYP DTWSTPHSYF SLTFCVQVQG KNKREKKLFT DQTSAKVTCH KDANIRVQAR DRYYSSFWSE WASVSCS
Expression Region 23-327
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Goat Interleukin-12 subunit beta(IL12B),Mammalian cell
Code CSB-MP011587GO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence IWELEKNV YVVELDWYPN APGETVVLTC DTPEEDGITW TSDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSRS LLLLHKKEDG IWSTDILKDQ KEPKAKSFLK CEAKDYSGHF TCSWLTAIST NLKFSVKSSR GSSDPRGVTC GAASLSAEKV SMDHREYNKY TVECQEGSAC PAAEESLPIE VVMEAVHKLK YENYTSSFFI RDIIKPDPPK NLQLRPLKNS RQVEVSWEYP DTWSTPHSYF SLTFCVQVQG KNKREKKLFT DQTSAKVTCH KDANIRVQAR DRYYSSFWSE WASVSCS
Expression Region 23-327
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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