IL12B, the interleukin 12β chain, is an important cytokine produced by inflammatory cells such as activated macrophages.IL12B is linked to the 35 kDα chain encoded by the IL12A gene by disulfide bonds to form a heterodimer, the biologically active IL-12.Its mechanism of action is mainly through binding to its receptor IL-12R, which activates the JAK-STAT Its mechanism of action is mainly through binding to its receptor IL-12R, activating the JAK-STAT signaling pathway, especially through the JAK2/STAT4 pathway, promoting the differentiation and activation of Th1 cells, and enhancing the ability of T cells and NK cells to produce interferon-gamma (IFN-γ).IL12B plays a key role in the Th1-type immune response and promotes cell-mediated immune responses against intracellular pathogens and tumour cells. In addition, IL12B expression and activity have been implicated in the pathogenesis of autoimmune diseases such as multiple sclerosis.
Popular Product:
IL12B Recombinant Monoclonal Antibody (CSB-RA895985A0HU)
Validated Data
Overlay Peak curve showing A549 cells stained with CSB-RA895985A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
The following IL12B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL12B Proteins
IL12B Proteins for Capra hircus (Goat)
IL12B Proteins for Ovis aries (Sheep)
IL12B Proteins for Mus musculus (Mouse)
IL12B Proteins for Homo sapiens (Human)
IL12B Proteins for Bos taurus (Bovine)
IL12B Proteins for Macaca mulatta (Rhesus macaque)
IL12B Proteins for Felis catus (Cat) (Felis silvestris catus)
IL12B Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
IL12B Proteins for Cervus elaphus (Red deer)
IL12B Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
IL12B Proteins for Sus scrofa (Pig)
IL12B Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)
IL12B Proteins for Marmota monax (Woodchuck)
IL12B Proteins for Bubalus bubalis (Domestic water buffalo)
IL12B Proteins for Lama glama (Llama)
IL12B Proteins for Papio anubis (Olive baboon)
IL12B Proteins for Mesocricetus auratus (Golden hamster)
IL12B Proteins for Cavia porcellus (Guinea pig)
IL12B Proteins for Sigmodon hispidus (Hispid cotton rat)
IL12B Proteins for Equus caballus (Horse)
IL12B ELISA Kit
IL12B ELISA Kit for Homo sapiens (Human)
IL12B ELISA Kit for Mus musculus (Mouse)
IL12B ELISA Kit for Sus scrofa (Pig)
IL12B ELISA Kit for Capra hircus (Goat)
