Recombinant Human Proto-oncogene vav(VAV1) ,partial

Code CSB-YP025803HU
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Source Yeast
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Code CSB-EP025803HU
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Source E.coli
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Code CSB-EP025803HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP025803HU
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Source Baculovirus
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Code CSB-MP025803HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names VAV1
Uniprot No. P15498
Alternative Names Oncogene vav; p95Vav; Proto-oncogene vav; Protooncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; VAV_HUMAN; VAV1
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Gene References into Functions
  1. Study identifies the residues on EZH2 that are critical for its interaction with VAV and demonstrate that EZH2 interactions with VAV proteins are crucial for the regulation of adhesion dynamics and cellular transformation. PMID: 28967906
  2. These results support a driver oncogenic role for VAV1 signaling in the pathogenesis of PTCL. PMID: 28062691
  3. no significant association of FoxP3 promoter rs3761548 or (GT) n repeat length with presumed immunological graft failure. The genotype frequencies of Vav1 intron polymorphisms did not significantly differ between patients with graft failure and matched controls. PMID: 28470865
  4. Data show that GEF Vav1 possesses tumor-suppressor functions in immature T cells. PMID: 29136506
  5. Polymorphisms of VAV1 gene is associated with Rheumatoid arthritis. PMID: 28053322
  6. Vav1 expression is increased in esophageal squamous cell carcinoma, indicates poor prognosis, and can serve as a candidate molecular prognostic marker. PMID: 28336434
  7. TGFbeta induced the dissociation of DNMT1 from the VAV1 promoter, leading to demethylation and the subsequent ectopic expression of VAV1 in cancer cells via a SMAD4-dependent mechanism PMID: 27893715
  8. Our results suggest the existence of a Vav1/PU.1/miR-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia -derived cells PMID: 27480083
  9. revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta, epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases PMID: 26043137
  10. Data indicate that only a single mutation in the proto-oncogene Vav1 enhances tumorigenicity. PMID: 25426554
  11. These findings establish VAV1 as a critical epigenetically regulated oncogene with a key role in MBSHH maintenance, and highlight its potential as a validated therapeutic target and prognostic biomarker for the improved therapy of medulloblastoma. PMID: 25531316
  12. The present study implies that estrogen-estrogen receptor modulates the transcription and expression of Vav1, which may contribute to the proliferation of cancerous cells. PMID: 24905577
  13. The role of Vav1 in T leukemia survival by selectively triggering Rac2-Akt axis and elevating the expression of anti-apoptotic Bcl-2. PMID: 24880064
  14. results presented herein suggest a potential cross-talk between cancer cells and the microenvironment controlled by CSF1/Vav1 signaling pathways. PMID: 25313137
  15. our data provide evidence that Vav1 is the linker molecule that couples CD28 to PIP5Kalpha activation and strongly fit with a potential model in which CD28 regulates PIP2 synthesis and turnover in T lymphocytes. PMID: 25539813
  16. suggest that Vav1 promotes the matrix-degrading processes underlying tumor cell migration and further, under conditions of ectopic Vav1 expression, that Vav1 is a central regulator and major driver of invasive matrix remodeling by pancreatic tumor cells PMID: 24332539
  17. VAV1 overexpression in both SKOV3 and human ovarian surface epithelial cells demonstrated that its upregulation of an E-cadherin transcriptional repressor, Snail and Slug, was not confined to ovarian cancer cells PMID: 23856093
  18. The results highlight for the first time the potential role of Vav1 as an oncogenic stress activator in cancer and the p53 dependence of its pro-apoptotic effect in breast cells. PMID: 23342133
  19. study provides evidence the large GTPase Dyn2 regulates the small GTPase Rac1 to potentiate invasive migration of pancreatic tumor cells; Dyn2 plays an essential role in regulating Rac1-mediated pancreatic tumor cell migration through modulation of the Rac1 activator Vav1 via a direct interaction PMID: 23537630
  20. c-Abl tyrosine kinase plays a critical role in beta2 integrin-dependent neutrophil migration by regulating Vav1 activity. PMID: 23325923
  21. TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA. PMID: 23420881
  22. immunohistochemical experiments revealed that VAV1 is not expressed in glioma cells. Instead, VAV1 is found in non-tumoural astrocyte-like cells that are located either peritumouraly or perivascularly PMID: 22864683
  23. This study highlights the importance of the N-terminal 20 aa of Vav1 for CaM binding, and provides new insights into the distinguished and irreplaceable role of Vav1 in T cell activation and signal transduction. PMID: 23271736
  24. Suggest Vav1 as an autosomal dominant disease gene associated with common variable immunodeficiency with defective T-cell function. PMID: 23058036
  25. these results establish LIME as a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of Vav(Vav guanine nucleotide exchange factor) PMID: 22395814
  26. both T cell activation and the association between SLP-76 and Nck. After T cell receptor stimulation, SLP-76 was phosphorylated, which enabled the binding of Nck. PMID: 22534133
  27. Substituting Vav1-specific residues into the C1b domain of PKCdelta, we identified five crucial residues (Glu(9), Glu(10), Thr(11), Thr(24), and Tyr(26)) along the rim of the binding cleft that weaken binding potency in a cumulative fashion. PMID: 22351766
  28. These data identify two regulatory mechanisms for vav1 expression: binding of c-Myb and CpG methylation of 5' regulatory sequences. PMID: 22253833
  29. results provide the first evidence that, at least in maturation of tumoral myeloid precursors, Vav1 is part of interconnected networks of functionally related proteins ended to regulate different aspects of gene expression PMID: 21856460
  30. Data reveal a key role for Vav1-dependent T cell antigen receptor signaling in Foxp3 natural T(reg) cell development. PMID: 21948080
  31. EHD2 associates in the plasma membrane with Vav1, a Nek3-regulated GEF (guanine-nucleotide-exchange factor) for Rho GTPases. PMID: 21756249
  32. In tumoral promyelocytes, Vav1 is a component of lineage-specific transduction machineries that can be recruited by various differentiating agents. PMID: 21647562
  33. The integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in NK cells. PMID: 21632469
  34. CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients. PMID: 21344162
  35. Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses. PMID: 21386095
  36. LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade PMID: 21206905
  37. VAV1 protects Jurkat cells from apoptosis by promoting Bcl-2 transcription through its guanine nucleotide exchange factor activity. PMID: 21151158
  38. Vav-1 expression may be associated with activated B-cell DLBCL origin and higher proliferative activity, and indicate Vav-1 as a potential marker to identify tumours likely to respond to CD40-targeted therapies. PMID: 20155735
  39. Results define the composition, stoichiometry and specificity of interactions in the SLP-76, Nck and VAV1 complex, which is crucial for regulation of the actin machinery after T-cell activation. PMID: 20562827
  40. overexpression of a mutated form of Vav1, in which Y745 was replaced with a phenylalanine, significantly reduced the ATRA-induced CD11b expression and essentially abrogated the differentiation-related acquisition of the migratory capability PMID: 20028078
  41. gene knockdown blocks NK cell cytotoxicity triggered by NKG2D and 2B4 coengagement PMID: 20189481
  42. These data reveal unexpected negative roles for Vav1 and RasGRF2 in different stages of T-cell lymphoma progression. PMID: 20011522
  43. Study reports the structure and biophysical and cellular analyses of the five-domain autoinhibitory element of Vav1; the catalytic Dbl homology (DH) domain of Vav1 is controlled by two energetically coupled processes. PMID: 20141838
  44. IDO suppressed Vav1 mRNA and protein production in T cells. IDO inhibited TCR-activation-induced Vav1 phosphorylation. PMID: 19597340
  45. signaling is required for T-cell activation partly by inhibiting activation-induced proteolysis of Vav1. PMID: 19880579
  46. ATRA-induced increase of Vav1 expression and phosphorylation may be involved in recruiting PU.1 to the CD11b promoter and in regulating CD11b expression during the late stages of neutrophil differentiation of APL-derived promyelocytes. PMID: 19747912
  47. In vitro, Vav is a regulated guanine nucleotide dissociation inhibitor for Ras PMID: 11716957
  48. mechanisms by which Vav1 can regulate c-fos serum response element transcriptional activity PMID: 11859076
  49. Vav exchange factor counteracts Leu3a monoclonal antibody-mediated signals inducing apoptosis and mitochondrial damage in Jurkat T cells by decreasing Bax expression. PMID: 12055221
  50. Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells (SLP-76) PMID: 12084069

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Tissue Specificity Widely expressed in hematopoietic cells but not in other cell types.
Database Links

HGNC: 12657

OMIM: 164875

KEGG: hsa:7409

STRING: 9606.ENSP00000472929

UniGene: Hs.116237

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