Fc gamma receptors generate signals within their cells through an important activation motif, ITAM. All of the Fc gamma receptors (FcγR) belong to the immunoglobulin superfamily. Fc gamma receptor is essential participant in many immune system effector functions, such as phagocytosis of opsonized, release of inflammatory mediators and antibody-dependent cellular cytotoxicity. Phagocytosis is triggered by clustering of FcγR at sites where leukocytes make contact with the opsonized particles. It is an essential component of the innate immune response and plays a crucial role in host-defense mechanisms by the uptake and destruction of infectious pathogens. Specialized cell types take part in this process in higher organisms, including macrophages, neutrophils, and monocytes. Upon opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
|AKT1||AKT1 Antibody||AKT1 Protein||AKT1 cDNA||AKT1 ELISA Kit|
|AKT2||AKT2 Antibody||AKT2 Protein||AKT2 cDNA||AKT2 ELISA Kit|
|AKT3||AKT3 Antibody||AKT3 Protein||AKT3 cDNA||AKT3 ELISA Kit|
|AMPH||AMPH Antibody||AMPH Protein||AMPH cDNA||AMPH ELISA Kit|
|ARF6||ARF6 Antibody||ARF6 Protein||ARF6 cDNA||ARF6 ELISA Kit|
|ARPC1A||ARPC1A Antibody||ARPC1A Protein||ARPC1A cDNA||ARPC1A ELISA Kit|
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|ARPC2||ARPC2 Antibody||ARPC2 Protein||ARPC2 cDNA||ARPC2 ELISA Kit|
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|ARPC5L||ARPC5L Antibody||ARPC5L Protein||ARPC5L cDNA||ARPC5L ELISA Kit|
|ASAP1||ASAP1 Antibody||ASAP1 Protein||ASAP1 cDNA||ASAP1 ELISA Kit|
|ASAP2||ASAP2 Antibody||ASAP2 Protein||ASAP2 cDNA||ASAP2 ELISA Kit|
|ASAP3||ASAP3 Antibody||ASAP3 Protein||ASAP3 cDNA||ASAP3 ELISA Kit|
|BIN1||BIN1 Antibody||BIN1 Protein||BIN1 cDNA||BIN1 ELISA Kit|
|CDC42||CDC42 Antibody||CDC42 Protein||CDC42 cDNA||CDC42 ELISA Kit|
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|CFL2||CFL2 Antibody||CFL2 Protein||CFL2 cDNA||CFL2 ELISA Kit|
|CRK||CRK Antibody||CRK Protein||CRK cDNA||CRK ELISA Kit|
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