Recombinant Mouse NF-kappa-B essential modulator (Ikbkg)

1. NEMO deficiency hampered activation of IKK complex in osteoclast precursors, causing arrest of osteoclastogenesis and apoptosis. Interestingly, inhibiting apoptosis by genetic ablation of TNFr1 significantly increased cell survival, but failed to rescue osteoclastogenesis or reverse osteopetrosis. PMID: 27435916
2. NEMO was critically involved in the cGAS-STING pathway. PMID: 28939760
3. This study provides evidence for a protective function of canonical IKK/NF-kappaB signalling in the arenchymal compartment during pancreatitis. In the absence of the regulatory IKK subunit NEMO, a combination of a fibrogenic gene signature, enhanced acinar-ductal metaplasia and a lack of regeneration contribute to the exacerbation of pancreatitis. PMID: 27464707
4. E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression. PMID: 28515148
5. robust caspase activation in NEMO-deficient cells is concomitant with RIPK3 recruitment to the apoptosis-mediating complex. PMID: 27560715
6. Whereas Parkin has been reported to positively regulate the expression of OPA1 through NEMO, herein we found that PARK2 overexpression did not modify the expression of OPA1. PMID: 26024391
7. prevents colon inflammation by NF-kappaB-independent functions PMID: 26982364
8. Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. PMID: 26786105
9. SENP1 deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB activity, cytokine production and pancreatic inflammation. PMID: 26596471
10. Crucial functions of inflammatory TAK1-NEMO signaling in protecting the brain endothelium and maintaining normal brain function. PMID: 26347470
11. Data show that NEMO protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) kinase activity-driven hepatocyte apoptosis. PMID: 26555174
12. Data show that the in utero death of NF-NF-kappaB essential modulator (NEMO) and cylindromatosis protein double mutant mice is mediated by TNF receptor 1 (TNFR1) signaling and can be rescued by TNFR1 deficiency. PMID: 26224629
13. signaling through NEMO might not only be involved in the production of NF-kappaB proinflammatory chemokines but also regulates podocyte dynamics independently of NF-kappaB PMID: 26268269
14. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54. PMID: 25400026
15. NEMO deficiency results in apoptosis, the development of liver fibrosis and hepatocellular carcinoma, all of which are substantially alleviated by allogeneic hepatocyte transplantation. PMID: 24979756
16. Mass spectrometric analysis demonstrated that WA covalently modifies NEMO on a cysteine residue within the C-terminal zinc finger (ZF) domain. Point mutations to the ZF can reverse the WA-induced Lys-48-polyubiquitin binding phenotype PMID: 25296760
17. Authors propose a model in murine cytomegalovirus virion-associated protein M45 delivered by viral particles activates NF-kappaB, presumably involving an interaction with RIP1 and NEMO. PMID: 24942588
18. NEMO ubiquitination is required for optimal innate immune signaling responses. These findings suggest that NEMO ubiquitination is crucial for NF-kappaB activity in response to innate immune agonists. PMID: 23871670
19. NEMO ZF, like other NEMO related-ZFs, binds mono-Ub and di-Ub with distinct stoichiometries, indicating the presence of a new Ub site within the NEMO ZF. PMID: 24100029
20. NEMO, an IKK subunit necessary for canonical NF-kappaB activation, is dispensable for normal pancreatic development and function, but essential for the propagation of KRAS-induced PanIN lesions. PMID: 22751123
21. The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO PMID: 23453807
22. In livers of mice, expression of NEMO and activation of NF-kappaB are required for hepatocyte proliferation and liver regeneration. PMID: 22922425
23. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. PMID: 23028469
24. Murine cytomegalovirus inhibits the inflammatory cascade by blocking Toll-like receptor and IL-1 receptor-dependent NF-kappaB activation through an interaction of the viral M45 protein with the NF-kappaB essential modulator. PMID: 22319449
25. When peptides containing the NF-kappaB essential modulator (NEMO) binding domain disrupt the IkappaB kinase (IKK)gamma complex, NF-kappaB activation is blocked, necrosis is decreased and regeneration is increased. PMID: 21624467
26. NEMO Lysine392, a well-established K63-linked polyubiquitination site, is an important mediator of polymethylmethacrylate-induced osteolysis. PMID: 21913221
27. tumor necrosis factor alpha-induced necroptosis requires the adaptor proteins FADD and NEMO. PMID: 21746883
28. Data show that DNA damage stimulates the formation of a cytosolic complex of ATM, NEMO, RIP1, and TAK1, and that TAK1 mediates the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. PMID: 21606198
29. ANXA1 can constitutively activate NF-kappaB in breast cancer cells through the interaction with the IKK complex PMID: 21383699
30. the effects of individually deleting the NEMO-binding domains in IKK alpha and IKK beta on classical NF-kappa B signaling and IKK complex formation. PMID: 19666475
31. binding of linear ubiquitin chains to NEMO in NF-kappaB activation PMID: 21153314
32. PAD2 interacts with IKKgamma and suppresses NF-kappaB activity. PMID: 20937835
33. ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-kappaB activation following genotoxic stimuli. PMID: 20932476
34. RNAi down-regulation of the expression of IKKalpha and IKKgamma also down-regulated the expression of NF-KappaB p65, p50 and p105 proteins both in cytoplasm and nucleus. PMID: 19278579
35. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. PMID: 20133626
36. BAG3 alters the interaction between HSP70 and IKKgamma, increasing availability of IKKgamma and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB activity and survival PMID: 20368414
37. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation PMID: 20164171
38. an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection PMID: 19956647
39. Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes. PMID: 19850942
40. The carboxyl-terminal region of IKKgamma is required for full IKK activation PMID: 12192055
41. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells PMID: 12352969
42. NEMO is not required for B cell development but plays an important role in B cell survival PMID: 12538858
43. NEMO trimerization domain is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains PMID: 15107419
44. a cell-permeable NBD peptide has been shown to block association of NEMO with the IKK complex and inhibit activation of NF-kappaB PMID: 15252035
45. Activation of IKK may be mediated by direct interaction with mutant huntingtin. The expanded polyglutamine stretch & adjacent Pro-rich motifs interact with IKKgamma. Expression of IKKgamma promotes aggregation & nuclear localization of mutant Htt exon-1. PMID: 15371500
46. overexpression of IKKgamma inhibits activation of NF-kappaB by NIK by competing with NIK for interaction with IKKbeta PMID: 15528996
47. TLR8-mediated MEKK3-dependent IKKgamma phosphorylation might play an important role in the activation of IKK complex, leading to IkappaBalpha phosphorylation PMID: 16737960
48. Deletion of the N-terminus of IKKgamma induces apoptosis in keratinocytes. PMID: 17184772
49. Deletion of NEMO in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma PMID: 17292824
50. protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator is regulated by heptad repeats, which are targeted by HTLV-I tax PMID: 17314097

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KEGG: mmu:16151

STRING: 10090.ENSMUSP00000004330

UniGene: Mm.12967