Recombinant Rat 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Plcg1), partial

1. These findings indicate that c-Jun induces PLCgamma1 expression transcriptionally and enhances rapid epithelial restitution after injury by activating Ca(2+) signal. PMID: 28100486
2. These results suggest that colitis-induced and brain-derived neurotrophic factor-mediated calcitonin generelated peptide expression in sensory activation is regulated by a unique pathway involving brain-derived neurotrophic factorphospholipase C gamma-cAMP-responsive element binding protein axis. PMID: 27306412
3. FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1. PMID: 26687682
4. PDGF activates the GIT1PLCG1mediated ERK1/2 pathway to control chondrocyte proliferation. PMID: 25175053
5. The content of Na(+) and K(+) in the diet regulated chromosome X levels in endothelial cells and activated PLC-gamma1 levels in rats PMID: 24785188
6. Periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis in part by activating the ERK1/2 mitogenic signal through the integrin beta 1-Src-phospholipase C-gamma-1/Rac1-ERK1/2 pathway. PMID: 22890232
7. These data indicate that PLC-gamma1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-gamma1. PMID: 22390417
8. The Epo/EpoR complex plays a critical role in the adhesion and migration of rat fibroblasts, and its functional inactivation is associated with PLC-gammal-dependent reduction of cell-matrix adhesion and this also affects cell migration. PMID: 21360263
9. Activation of FGF receptor 1 (FGFR1), largely through two key cytoplasmic amino acid residues that are linked to MAPK and PLC activation, suffices to promote adult neural stem cell self-renewal. PMID: 19505325
10. Prolonged protein turnover of glyceraldehyde-3-phosphate dehydrogenase by phospholipase C-gamma 1 is critical for anchorage-independent growth and ATP synthesis in transformed cells. PMID: 21210726
11. Data show that PLC-gamma isozymes link phosphorylation to phospholipase activation by elaborating upon primordial regulatory mechanisms found in other PLCs. PMID: 20807769
12. Silencing of either c-Fos or c-Jun also depressed the norepinephrine-mediated increases in PLC beta(1), beta(3) and gamma(1) protein content and activity in an isozyme specific manner. PMID: 19538471
13. The Y509A/F510A mutant is more susceptible to receptor tyrosine kinase-induced Y783 phosphorylation than is wild-type PLC-gamma1, but no longer requires Y783 phosphorylation step for the Y509A/F510A mutant PLC-gamma1 activation in vivo. PMID: 20164676
14. Transfection of phosphatidylethanolamine N-methyltransferase 2 gene can inhibit the phosphorylation and translocation from cytosol to plasma membrane of PLC gamma 1. PMID: 16867273
15. cell adhesion to alpha(1)beta(1)-specific substrates results in the association of phospholipase Cgamma (PLCgamma) with the alpha(1)beta(1) integrin independent of PLCgamma tyrosine phosphorylation PMID: 11724770
16. acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer) PMID: 11823862
17. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity PMID: 11886851
18. Data show that motor function recovery and expression of neuronal nitric oxide synthase and phospholipase C-gamma1 was highly enhanced in regenerated nerves exposed to pulsed electromagnetic field. PMID: 11989979
19. Phospholipase C-gamma is required for agonist-induced Ca2+ entry. PMID: 12437926
20. Increases in PLC gamma(1) and delta(1) activities occurred upon reperfusion, but were not accounted for by altered mRNA and protein levels. The results indicate that ischemia-reperfusion induces differential changes in PLC isozymes. PMID: 12623065
21. PLC-gamma1 directly interacts with PLD2; this interaction is important for PLC-gamma1 activity PMID: 12646582
22. findings suggested that expression levels of phospholipase c-beta1, delta1 and gamma1 isozymes are altered by hyperoxia and acrylonitrile, but there are apparent differences in these levels between the different levels of oxidative stress and organs PMID: 12850505
23. Phospholipase C gamma1 in distinct regions of the ventral tegmental area differentially modulates adaptations to drugs of abuse and aversive stimuli. PMID: 12930795
24. PLCgamma function and activation are mediated by GIT1 through c-Src, which integrates signal transduction by GPCRs and TKRs PMID: 14523024
25. The pleckstrin homology domain of Plcg1 interacts with human insulin receptor. PMID: 14568990
26. the lipase activity of PLC-gamma1 mediates NGF-regulated MAPK signaling upstream of Ras/Rap1 activation probably through second messenger DAG-activated Ras and Rap-GEFs PMID: 14570902
27. Tyr-783 phosphorylation of of phospholipase C-gamma 1 is not sufficient for enzyme activation PMID: 15161916
28. Phospholipase C gamma 1 (PLCgamma1)sequestering peptides significantly impaired long-term memory, but not memory acquisition, suggesting a role for PLCgamma1-mediated signaling in spatial memory. PMID: 15169852
29. Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and has a role in dynamin-1-dependent epidermal growth factor receptor endocytosis PMID: 15252117
30. a previously unidentified mechanism for the integration of PLC-gamma1- and ERK2-dependent signaling PMID: 15258148
31. Repeated inescapable shock decreased the expression of PLC beta1 and PLC gamma1 isozymes in the brain. PMID: 15536495
32. results suggest that PLC-gamma1 and beta-tubulin transmodulate each other, i.e. that PLC-gamma1 modulates microtubule assembly by beta-tubulin, and beta-tubulin promotes PLC-gamma1 activity. PMID: 15579910
33. Data reveal that the amino acid residues Pro(500) and His(503) are critical for binding of phospholipase C-gamma1 to one of its substrates, PI(4,5)P(2) in the membrane. PMID: 15607032
34. the partial PH domain of PLC-gamma1 interacts with a complementary partial PH-like domain in TRPC3 to elicit lipid binding and cell-surface expression of TRPC3 PMID: 15744307
35. Amino-terminal PH domain of PLC-gamma1 was identified to bind 68-kDa neurofilament light chain (NF-L). PMID: 16819285
36. Results describe the role of phospholipase C-gamma in NGF-stimulated differentiation and gene induction. PMID: 16841466
37. polyamine-mediated PLC-gamma1 signaling stimulates cell migration during restitution as a result of increased calcium concentration. PMID: 16973916
38. activation of both PI3Kgamma and tyrosine kinase is a prerequisite for AII-induced stimulation of PLCgamma1 in vascular smooth muscle PMID: 16989733
39. overexpression of PLCgamma1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. PMID: 17196935
40. It is concluded that the PLC-gamma1 protein, independently of IP3 generation and STIM1, is required to couple endoplasmic reticulum Ca2+ release to the activation of store-operated Ca2+ channels in the plasma membrane of H4IIE liver cells. PMID: 17432954
41. Simplexvirus-mediated overexpression of PLCgamma1 in PC12 cells induced ERK activation via a mechanism dependent on protein kinases. PMID: 17524370
42. the proliferation activity of PLC gamma1 via its SH3 domain may be coupled with the flight from growth arrest by nerve growth factors, thereby inhibiting neuronal differentiation. PMID: 17618160
43. Activation of PLCgamma1 and subsequent Ca(2+)(i) mobilisation mediate H(2)O(2)-induced VSOR Cl(-) currents, indicating that H(2)O(2) operates via redox-sensitive signalling pathways akin to those activated by osmotic challenges. PMID: 17982259
44. Data show that GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src signaling pathways, is dependent on versican, and inviolves non-peptidergic nociceptors. PMID: 18616564
45. Nephrin Tyr-1204 phosphorylation triggers the Ca(2+) response in a PLC-gamma1-dependent fashion. PMID: 19179337
46. Lck and c-Src kinases appear to play an important role in regulating tyrosine phosphorylation of phospholipase C1 and contractile activity in the rat uterus. PMID: 19208792
47. EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells. PMID: 19605547

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KEGG: rno:25738

STRING: 10116.ENSRNOP00000022276

UniGene: Rn.11243