IFNAR1 Antibody

Code CSB-RA011046A0HU
Size US$350
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Product Details

Uniprot No. P17181
Target Names IFNAR1
Alternative Names Alpha type antiviral protein antibody; Antiviral protein, alpha-type antibody; Antiviral protein, beta-type antibody; AVP antibody; Beta type antiviral protein antibody; CRF2-1 antibody; Cytokine receptor class-II member 1 antibody; Cytokine receptor family 2 member 1 antibody; IFN alpha REC antibody; IFN alpha receptor antibody; IFN alpha/beta Receptor alpha antibody; IFN beta receptor antibody; IFN Interferon-beta receptor antibody; IFN-alpha/beta receptor 1 antibody; IFN-R-1 antibody; IFNAR antibody; Ifnar1 antibody; IFNBR antibody; IFRC antibody; INAR1_HUMAN antibody; Interferon (alpha beta and omega) receptor 1 antibody; interferon alpha and beta receptor subunit 1 antibody; Interferon alpha/beta receptor 1 antibody; Interferon alpha/beta receptor alpha chain antibody; Interferon beta receptor 1 antibody; interferon receptor 1 antibody; Interferon-alpha receptor antibody; Type I interferon receptor 1 antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human IFNAR1
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1
Gene References into Functions
  1. IFNAR1 signaling underlies an increased risk of tuberculosis in humans and reveals a function for the IFNAR1 inter-domain region in cytokine-cytokine receptor interaction and signal transduction. PMID: 29311663
  2. HCV-1b core protein-induced miR-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR-93-5p-IFNAR1 axis regulates STAT1 phosphorylation. PMID: 29375208
  3. Relapsing-remitting multiple sclerosis patients manifested a statistically higher expression level of IFNAR1 than their normal counterparts. PMID: 28282804
  4. cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1. PMID: 29343571
  5. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
  6. Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer. PMID: 28842285
  7. Here, we review the current knowledge on the main strategies that human pathogenic flaviviruses utilize to escape both type I IFN induction and effector pathways. [review] PMID: 28576494
  8. the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy. PMID: 27346865
  9. Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche. PMID: 28196594
  10. These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication. PMID: 27569280
  11. this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo in Estonian patients PMID: 26429320
  12. A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1. PMID: 25072284
  13. rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations. PMID: 26679744
  14. Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection. PMID: 25939635
  15. data illustrate a lipid G-protein coupled receptor (GPCR)-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 signaling PMID: 26787880
  16. Data suggest IFNA2 (interferon, alpha 2) binding to extracellular domain of IFNAR1 or IFNAR2 promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes. PMID: 26679999
  17. These findings suggest that influenza A virus hemagglutinin causes IFNAR1 degradation, which in turn helps the virus escape the powerful innate immune system. PMID: 26676772
  18. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control. PMID: 26159719
  19. IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients PMID: 25675103
  20. The expression of IFNAR1, IFNgammaR1 and ribovarin transporters were significantly impaired in chronic liver disease and cirrhotic livers. PMID: 25265476
  21. Results show that SNPs in IFNAR1 and IFNG were risk factors for malaria in Indian population. PMID: 25445652
  22. sequence variants of both the IFNAR1-17470 and IL-10-592 genes were correlated with susceptibility to chronic hepatitis B. PMID: 25501140
  23. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18. PMID: 26008745
  24. The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented. PMID: 24704786
  25. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection. PMID: 23663046
  26. [review] The type I interferon system has an important role in the pathogenesis of Sjogren's syndrome. PMID: 23201923
  27. Results identified genetic variants in interferon genes that influence melanoma progression and survival with modulation of effect due to treatment status. PMID: 23209811
  28. PTP1B is a specific regulator of IFNAR1 endocytosis. PMID: 23129613
  29. common genetic changes in IFNAR1 may influence HCC risk, likely through miR-1231-mediated regulation. PMID: 22824466
  30. These new findings reveal distinct and overlapping signaling mechanisms used by B-cell antigen receptor and IFNAR in the regulation of TLR7 tolerance and activation. PMID: 22786773
  31. Systemic lupus erythematosus patients are found to have the highest serum type I IFN activity; in contrast, the untreated relapsing-remitting multiple sclerosis population has the lowest levels of endogenous IFN-alpha/beta activity. PMID: 22036215
  32. 2A protease encoded by EV71 as an antagonist of IFNB1 and the protease activity is required for reducing IFNAR1 levels. PMID: 22258259
  33. HBX expression downregulates type I IFN receptor, leading to disturbance of extracellular type I IFN signaling. PMID: 22218495
  34. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
  35. Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes. PMID: 22162633
  36. Early progenitors and mature megakaryocytes, but not platelets, express functional IFNAR and synthetize/release IFN-beta, revealing not only that megakaryo/thrombopoiesis regulation by IFN-I is associated with a specific interaction with its receptor PMID: 22136495
  37. IFNalphaR is dispensable on responding CD4+ T cells. Cells derived from transgenic bone marrow are sufficient to restore IFNalphaR-dependent pathways in IFNalphaR-deficient mice. PMID: 22156349
  38. Tyrosine phosphorylation of PKD2 is required for IFNalpha-stimulated activation of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ensuing restriction of the extent of cellular responses to IFNalpha. PMID: 21865166
  39. In cells exposed to VEGF, phosphorylation-dependent degradation of IFNAR1 leads to an inhibition of type 1 IFN signaling and is required for efficient VEGF-stimulated angiogenesis. PMID: 21832278
  40. The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of hepatitis C virus to exogenous interferon alpha. PMID: 21756311
  41. These data demonstrate that West Nile virus infection results in a reduction of IFNAR1 protein through a non-canonical protein degradation pathway, and may participate in the inhibition of the interferon response. PMID: 21830897
  42. activation of p38 kinase in response to pathogen-recognition receptors stimulation results in a series of phosphorylation events within the IFNAR1 chain of the Type I IFN receptor PMID: 21695243
  43. The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. PMID: 21757742
  44. A low number of receptors suffices for antiviral response and is thus a robust feature common to all cells. Conversely, a high number of receptors is required for antiproliferative activity, which allows for fine-tuning on a single-cell level. PMID: 21690295
  45. an important role of p38 kinase in the ligand-independent stimulation of IFNAR1 ubiquitination and degradation PMID: 21540188
  46. Expression and kinase activity of PKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1. PMID: 21173164
  47. Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. PMID: 19957332
  48. These results suggest that a combination of serum soluble interferon-alpha/beta receptor and high-sensitivity-CRP thresholds may be more reliable diagnostic parameter for gastrointestinal and hepatobiliary-pancreatic cancer. PMID: 19879773
  49. The expression of interferon-alpha receptor in liver tissues in patients with chronic hepatitis B correlates well with the pathological grading and alanine aminotransferase level. PMID: 19220955
  50. The 3a protein was found to induce serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and to increase IFNAR1 ubiquitination. PMID: 20020050
  51. Both ligand-dependent and -independent pathways converge on phosphorylation of Ser(535) within the IFNAR1 degron leading to recruitment of beta-Trcp E3 ubiquitin ligase and concomitant ubiquitination and degradation PMID: 19948722
  52. IFNAR1 (interferon-alpha receptor 1) (G/C in SNP18417) and IFNAR1 (interferon-alpha receptor 2) (G/T in SNP 11876) polymorphisms jointly, but not individually, may confer susceptibility to Behcets disease in a Turkish population PMID: 19796549
  53. Only the tyrosine-phosphorylated form of interferon alpha receptor subunit 1 binds to Stat2. PMID: 12220192
  54. Data show that Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. PMID: 12554654
  55. Measles virus suppresses interferon-alpha signaling pathway: association of viral accessory proteins, C and V, with interferon-alpha receptor complex PMID: 12620806
  56. An association has been demonstrated between two IFNAR1 polymorphisms and cerebral malaria. PMID: 12761564
  57. IFNAR1 interacts with the Homolog of Slimb (HOS) F-box protein in a phosphorylation-dependent manner, and that this interaction is promoted by interferon alpha PMID: 14532120
  58. IFNAR1 and IFNAR2 levels reveal that the KAS-6/1 cell line overexpresses IFNAR1 relative to other myeloma cell lines that are growth arrested by IFN-alpha. PMID: 14647450
  59. phosphorylation and ubiquitin acceptor sites are required for ubiquitination and degradation of IFNAR1 PMID: 15337770
  60. A dynamic model for the IFN-alpha/receptor complex predicts that IFNAR1 and IFNAR2 are probably anchored in close proximity on the cell surface and that upon IFN binding, the complex assumes a closed form, resulting in activation of intracellular kinases. PMID: 15449939
  61. The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence. PMID: 15589821
  62. analysis of the roles of the four Ig-like sub-domains (SDs) of the extracellular domain of ifnar1 (ifnar1-EC) for ligand recognition and receptor assembling PMID: 15946680
  63. The promoter GT repeat dinucleotide microsatellite polymorphism of the IFNAR1 gene may represent a risk factor for the development of depressive symptoms during IFN-alpha therapy for hepatitis C and other conditions. PMID: 15990456
  64. Monocyte-derived dendritic cells can modulate their sensitivity to two IFN subtypes through a differential regulation of the IFNAR subunits. PMID: 16624932
  65. Human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex. PMID: 17001036
  66. Polymorphisms of IFNAR1 promoter may affect, at least in part, the outcomes of HBV infection. PMID: 17125879
  67. constructed a phage display library by randomizing three positions on IFNalpha2 previously shown to confer weak binding to IFNAR1 PMID: 17310065
  68. The intensity and distribution of IFNAR-1 may predict the response to therapy with IFN-alpha and IFN-beta in pancreatic cancer. PMID: 17667505
  69. This study suggests that when combination therapy with high dose IFN-alpha and ribavirin is administered, HCV genotypes and age rather than the IFNAR1 polymorphisms are the predictors of a sustained response. PMID: 17823081
  70. report that in response to type 1 interferon (IFNalpha), IFNalpha type 1 receptors recruit cytoplasmic CREB-binding protein (CBP). PMID: 17923090
  71. Ubiquitination of IFNAR1 promotes its interaction with the adaptin complex that is required for the robust internalization of IFNAR1, implicating cooperation between site-specific ubiquitination and the linear endocytic motif in regulating this process. PMID: 18056411
  72. We discuss the signaling events that might lead to ubiquitination and degradation of IFNAR1 via ligand-dependent and independent pathways and their potential physiologic significance. PMID: 18166147
  73. An IFNAR1/retinoic acid-inducible gene I (RIG-I)-dependent pathway mediates SOCS1 and SOCS3 up-regulation in influenza A virus-infected bronchial epithelial cells. PMID: 18250407
  74. place TRAF2 directly in the signaling pathway transduced through the IFNAR1 subunit of the IFN receptor PMID: 18362156
  75. Tyk2 contributes to both the regulation of total IFNAR1 levels as well as the regulation of the cell surface density of this receptor chain. PMID: 18474601
  76. a major bottleneck was observed during POLIOVIRUS transit to the brain in PVR mice, but was absent in PVR-IFNAR-/- mice, suggesting that the interferon response was a determinant of the peripheral site-to-brain bottleneck PMID: 18535656
  77. In conclusion, IFNAR1 19158C/G polymorphism is primarily associated with susceptibility to chronic HBV infection. PMID: 18761606
  78. the stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities PMID: 18801736
  79. two variants of the IFNAR1 gene are associated with the clinical presentation of hepatitis B virus infection PMID: 19103527
  80. CD11c-Cre+/- ifnar1(fl/fl) transgenic mice respond with vigorous IFN-alpha production to mouse hepatitis virus infection, suggesting that lack of IFNAR on plasmacytoid dendritic cells has no significant impact on the early type I IFN response. PMID: 19124753
  81. Defective monocyte responses to IFNalpha/beta may play an important role in the pathogenesis of HIV-1 infection, and decreased IFNalpha/betaR expression may serve as a novel marker of disease progression. PMID: 19299650
  82. Upon HBV infection, decreased binding affinity of HMGB1 to the IFNAR1 promoter -3T variant is aggravated by the suppressed PARP-1 expression caused by HBV, resulting in a further attenuated IFNAR1 expression. PMID: 19501422
  83. Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha. PMID: 19561067
  84. Results suggest a role for mammalian and parasite casein kinase 1alpha in regulating IFNAR1 stability and type I IFN signaling. PMID: 19805514

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, Late endosome, Lysosome
Protein Families Type II cytokine receptor family
Tissue Specificity IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resi
Database Links

HGNC: 5432

OMIM: 107450

KEGG: hsa:3454

STRING: 9606.ENSP00000270139

UniGene: Hs.529400

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