IFNAR1 Antibody

Datasheet
Code CSB-RA011046A0HU
Size US$350
Uniprot No. P17181
Immunogen A synthesized peptide derived from human IFNAR1
Species Reactivity Human
Tested Applications ELISA
Relevance Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1, IFNAR
Immunogen Species Human
Protocols ELISA Protocol
Research Area Immunology
Gene Names IFNAR1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, Late endosome, Lysosome
Protein Families Type II cytokine receptor family
Tissue Specificity IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resi
Database Links

HGNC: 5432

OMIM: 107450

KEGG: hsa:3454

STRING: 9606.ENSP00000270139

UniGene: Hs.529400

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Necroptosis
Natural killer cell mediated cytotoxicity
NOD-like receptor signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway

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