Recombinant Human Interferon alpha/beta receptor 1(IFNAR1)

Code CSB-CF011046HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names IFNAR1
Uniprot No. P17181
Alternative Names Alpha type antiviral protein; Antiviral protein, alpha-type; Antiviral protein, beta-type; AVP; Beta type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN alpha REC; IFN alpha receptor; IFN alpha/beta Receptor alpha; IFN beta receptor; IFN Interferon-beta receptor; IFN-alpha/beta receptor 1; IFN-R-1; IFNAR; Ifnar1; IFNBR; IFRC; INAR1_HUMAN; Interferon (alpha beta and omega) receptor 1; interferon alpha and beta receptor subunit 1; Interferon alpha/beta receptor 1; Interferon alpha/beta receptor alpha chain; Interferon beta receptor 1; interferon receptor 1; Interferon-alpha receptor; Type I interferon receptor 1
Species Homo sapiens (Human)
Expression Region 28-557
Target Protein Sequence KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1
Gene References into Functions
  1. IFNAR1 signaling underlies an increased risk of tuberculosis in humans and reveals a function for the IFNAR1 inter-domain region in cytokine-cytokine receptor interaction and signal transduction. PMID: 29311663
  2. HCV-1b core protein-induced miR-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR-93-5p-IFNAR1 axis regulates STAT1 phosphorylation. PMID: 29375208
  3. Relapsing-remitting multiple sclerosis patients manifested a statistically higher expression level of IFNAR1 than their normal counterparts. PMID: 28282804
  4. cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1. PMID: 29343571
  5. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
  6. Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer. PMID: 28842285
  7. Here, we review the current knowledge on the main strategies that human pathogenic flaviviruses utilize to escape both type I IFN induction and effector pathways. [review] PMID: 28576494
  8. the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy. PMID: 27346865
  9. Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche. PMID: 28196594
  10. These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication. PMID: 27569280
  11. this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo in Estonian patients PMID: 26429320
  12. A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1. PMID: 25072284
  13. rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations. PMID: 26679744
  14. Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection. PMID: 25939635
  15. data illustrate a lipid G-protein coupled receptor (GPCR)-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 signaling PMID: 26787880
  16. Data suggest IFNA2 (interferon, alpha 2) binding to extracellular domain of IFNAR1 or IFNAR2 promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes. PMID: 26679999
  17. These findings suggest that influenza A virus hemagglutinin causes IFNAR1 degradation, which in turn helps the virus escape the powerful innate immune system. PMID: 26676772
  18. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control. PMID: 26159719
  19. IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients PMID: 25675103
  20. The expression of IFNAR1, IFNgammaR1 and ribovarin transporters were significantly impaired in chronic liver disease and cirrhotic livers. PMID: 25265476
  21. Results show that SNPs in IFNAR1 and IFNG were risk factors for malaria in Indian population. PMID: 25445652
  22. sequence variants of both the IFNAR1-17470 and IL-10-592 genes were correlated with susceptibility to chronic hepatitis B. PMID: 25501140
  23. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18. PMID: 26008745
  24. The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented. PMID: 24704786
  25. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection. PMID: 23663046
  26. [review] The type I interferon system has an important role in the pathogenesis of Sjogren's syndrome. PMID: 23201923
  27. Results identified genetic variants in interferon genes that influence melanoma progression and survival with modulation of effect due to treatment status. PMID: 23209811
  28. PTP1B is a specific regulator of IFNAR1 endocytosis. PMID: 23129613
  29. common genetic changes in IFNAR1 may influence HCC risk, likely through miR-1231-mediated regulation. PMID: 22824466
  30. These new findings reveal distinct and overlapping signaling mechanisms used by B-cell antigen receptor and IFNAR in the regulation of TLR7 tolerance and activation. PMID: 22786773
  31. Systemic lupus erythematosus patients are found to have the highest serum type I IFN activity; in contrast, the untreated relapsing-remitting multiple sclerosis population has the lowest levels of endogenous IFN-alpha/beta activity. PMID: 22036215
  32. 2A protease encoded by EV71 as an antagonist of IFNB1 and the protease activity is required for reducing IFNAR1 levels. PMID: 22258259
  33. HBX expression downregulates type I IFN receptor, leading to disturbance of extracellular type I IFN signaling. PMID: 22218495
  34. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
  35. Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes. PMID: 22162633
  36. Early progenitors and mature megakaryocytes, but not platelets, express functional IFNAR and synthetize/release IFN-beta, revealing not only that megakaryo/thrombopoiesis regulation by IFN-I is associated with a specific interaction with its receptor PMID: 22136495
  37. IFNalphaR is dispensable on responding CD4+ T cells. Cells derived from transgenic bone marrow are sufficient to restore IFNalphaR-dependent pathways in IFNalphaR-deficient mice. PMID: 22156349
  38. Tyrosine phosphorylation of PKD2 is required for IFNalpha-stimulated activation of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ensuing restriction of the extent of cellular responses to IFNalpha. PMID: 21865166
  39. In cells exposed to VEGF, phosphorylation-dependent degradation of IFNAR1 leads to an inhibition of type 1 IFN signaling and is required for efficient VEGF-stimulated angiogenesis. PMID: 21832278
  40. The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of hepatitis C virus to exogenous interferon alpha. PMID: 21756311
  41. These data demonstrate that West Nile virus infection results in a reduction of IFNAR1 protein through a non-canonical protein degradation pathway, and may participate in the inhibition of the interferon response. PMID: 21830897
  42. activation of p38 kinase in response to pathogen-recognition receptors stimulation results in a series of phosphorylation events within the IFNAR1 chain of the Type I IFN receptor PMID: 21695243
  43. The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. PMID: 21757742
  44. A low number of receptors suffices for antiviral response and is thus a robust feature common to all cells. Conversely, a high number of receptors is required for antiproliferative activity, which allows for fine-tuning on a single-cell level. PMID: 21690295
  45. an important role of p38 kinase in the ligand-independent stimulation of IFNAR1 ubiquitination and degradation PMID: 21540188
  46. Expression and kinase activity of PKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1. PMID: 21173164
  47. Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. PMID: 19957332
  48. These results suggest that a combination of serum soluble interferon-alpha/beta receptor and high-sensitivity-CRP thresholds may be more reliable diagnostic parameter for gastrointestinal and hepatobiliary-pancreatic cancer. PMID: 19879773
  49. The expression of interferon-alpha receptor in liver tissues in patients with chronic hepatitis B correlates well with the pathological grading and alanine aminotransferase level. PMID: 19220955
  50. The 3a protein was found to induce serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and to increase IFNAR1 ubiquitination. PMID: 20020050

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, Late endosome, Lysosome
Protein Families Type II cytokine receptor family
Tissue Specificity IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resi
Database Links

HGNC: 5432

OMIM: 107450

KEGG: hsa:3454

STRING: 9606.ENSP00000270139

UniGene: Hs.529400

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