IFNAR1, also known as Interferon beta receptor 1, interferon receptor 1, Interferon-alpha receptor, or Type I interferon receptor 1, is a component of the type I interferon receptor, encoded by a gene in human cells. The mechanism of action for IFNAR1 involves forming a heterodimeric receptor with the IFNAR2 subunit. Upon binding to interferon α and β, it activates Janus kinases (JAKs), which in turn activate the signal transducer and activator of transcription (STAT) signaling pathway, particularly through the phosphorylation of STAT1 and STAT2, leading to the formation of the ISGF3 complex and the promotion of interferon-stimulated gene (ISG) expression.
Biologically, IFNAR1 plays a key role in antiviral responses and immune regulation. It is involved not only in defense mechanisms against viral infections but also in the pathogenesis of tumor immunity and autoimmune diseases. For example, the IFNAR1-mediated signaling pathway can enhance the activity of natural killer (NK) cells, promote the function of monocytes and macrophages, and stimulate the maturation and migration of dendritic cells. Furthermore, dysfunctions in IFNAR1 may be associated with the pathogenesis of certain viral diseases, making it a potential target for antiviral therapies and immunomodulatory treatments.
IFNAR1 Antibody (CSB-PA107635)
Validated Data
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
The following IFNAR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IFNAR1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011046GA01HU | IFNAR1 Antibody | Human | ELISA,WB |
CSB-PA009471 | Phospho-IFNAR1 (Y466) Antibody | Human | WB, IHC, ELISA |
CSB-PA009473 | IFNAR1 Antibody | Human | IHC, IF, ELISA |
CSB-PA107635 | IFNAR1 Antibody | Human | IHC,ELISA |
CSB-RA011046A0HU | IFNAR1 Recombinant Monoclonal Antibody | Human | ELISA |
IFNAR1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP011046HU1 CSB-EP011046HU CSB-BP011046HU CSB-MP011046HU CSB-EP011046HU1-B |
Recombinant Human Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF011046HU | Recombinant Human Interferon alpha/beta receptor 1 (IFNAR1) | in vitro E.coli expression system |
IFNAR1 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP636729SH CSB-EP636729SH CSB-BP636729SH CSB-MP636729SH CSB-EP636729SH-B |
Recombinant Sheep Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR1 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP758824PI CSB-EP758824PI CSB-BP758824PI CSB-MP758824PI CSB-EP758824PI-B |
Recombinant Pig Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF011046MO | Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1) | in vitro E.coli expression system |
CSB-YP011046MO1 CSB-EP011046MO1 CSB-BP011046MO1 CSB-MP011046MO1 CSB-EP011046MO1-B |
Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |