Code | CSB-RA020470A421phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IF | 1:20-1:200 |
IP | 1:200-1:1000 |
The recombinant RPS6KB1 antibody expression is induced in mammalian cells transfected with a recombinant plasma vector. The recombinant plasma vector was constructed by inserting the gene coding for the antibody against RPS6KB1 into the plasma. The recombinant RPS6KB1 antibody was purified from the cell culture medium using affinity-chromatography. It can react with samples containing RPS6KB1 protein from Human and has been validated for use in the ELISA, WB, IF, IP.
The T421/S424 phospho-RPS6KB1 antibody can detect the RPS6KB1 protein phosphorylated at T421/S424 sites. RPS6KB1, also known as S6K1 or p70S6K, is a serine/threonine kinase of ribosomal protein and is essential for protein translation and elongation. It is involved in the PI3K/mTOR signaling pathway. Growth factors and hormones can activate RPS6KB1 by phosphorylating its numerous serine and threonine sites in a sequential manner. Active RPS6KB1 phosphorylates ribosomal protein S6, leading to selective translation of the 5'-terminal oligopyrimidine tract mRNAs that code for ribosomal proteins and elongation factors.
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