Recombinant Human C-X-C chemokine receptor type 3(CXCR3)

Code CSB-CF006253HU
Size US$3494Purchase it in Cusabio online store
(only available for customers from the US)
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names CXCR3
Uniprot No. P49682
Research Area Immunology
Alternative Names C-X-C chemokine receptor type 3; CD 183; CD182; CD183; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; Chemokine CXC Motif Receptor 3; CKR L2; CKR-L2; CKRL2; CMKAR3; CXC-R3; CXCR-3; CXCR3; CXCR3_HUMAN; G Protein Coupled Receptor 9 ; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 R; IP10 receptor; IP10-R; IP10R; Mig R; Mig receptor; Mig-R; MIGR
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Expression Region 1-368aa
Target Protein Sequence MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 44.7kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Isoform 1
Gene References into Functions
  1. High CXCR3 expression is associated with invasion and metastasis in tongue squamous cell carcinoma. PMID: 29286143
  2. Up-regulated CXCR3 is detectable in the amniotic fluid and associated with the presence of placental lesions consistent with maternal anti-fetal rejection so may serve as a potential marker of spontaneous preterm delivery. PMID: 28829757
  3. the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined. PMID: 28869080
  4. Results suggest that infiltration of chemokine (C-X-C motif) receptor 3 (CXCR3)-positive plasma cells is a characteristic feature of Hunner type interstitial cystitis (HIC). PMID: 27339056
  5. Results of this study indicate that CXCR3 overexpression in GC is associated with increased DC and TIL infiltration and improved OS. PMID: 29266971
  6. Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNgamma and IL-17 remained unchanged when co-cultured with chrysotile. PMID: 28498408
  7. In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation. PMID: 28206670
  8. Alternatively spliced variant of CXCR3 mediates the metastasis of liver cancer. PMID: 26883105
  9. The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding. PMID: 28945356
  10. approach has been able to describe the structural events which dynamically characterize the molecular mechanisms involved in the binding of CXCR3 to CXCL11 and the critical role exerted by its N-terminal region in "hunting" and capturing the ligand. PMID: 29054054
  11. High CXCR3 expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma. PMID: 29153094
  12. CD4(+)CXCR3(+) T cells are highly enriched in the inflamed mucosa of intestinal bowel disease patients. PMID: 26732675
  13. Up-regulation of CXCR3 chemokine and its ligands in bronchoalveolar lavage fluid during organizing pneumonia increases the risk of chronic lung allograft dysfunction after lung transplantation. PMID: 28686641
  14. These data suggest that elevated IP-10 levels may impair NK cell function during HIV infection and that IP-10/CXCR3 blocking may be a novel therapeutic strategy in the control and functional cure of HIV. PMID: 28465448
  15. Our result showed that CXCR2 expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 and CXCR3 expressions are related to poorer overall survival (P < 0.001; P < 0.001). PMID: 27273823
  16. The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. PMID: 28392462
  17. Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8+NKG2D+ T cells into the skin PMID: 27412416
  18. TNF-alpha augments CXCR2 and CXCR3 to promote the progression of renal cell carcinoma leading to a poor prognosis. PMID: 27297979
  19. TNF-alpha upregulated the expression of CXCR3 in HUVECs PMID: 27565063
  20. TLR9 ligands may contribute to the immunopathogenesis of sarcoidosis via induction of CXCL10 release in the alveolar macrophages. PMID: 27390897
  21. The CXCL10/CXCR3 axis mediates T-cell recruitment into the skin in progressive vitiligo. Blocking this chemotactic mechanism may present a new form of therapy. PMID: 26801009
  22. these data suggest that CXCR3A contributes to the growth, invasion and metastasis of gastric cancer cells in vitro and in vivo, and thus may be a key mediator of gastric cancer progression. PMID: 27461521
  23. IP-10 complexes with CXCR3, which in turn activates the ERK1/2 pathway, thus resulting in upregulation of p-CREB and increased vascular smooth muscle cell proliferation. PMID: 28111710
  24. the CXCR3+/CCR5+ expression was higher in the neoplastic as compared to the hyperplastic nodules. PMID: 27872865
  25. monocytes and lymphocytes cooperate to enhance migration towards CXCR3 chemokines and CCL5 in COPD PMID: 26965295
  26. CXCL10/CXCR3 axis promotes gastric cancer cell invasion and migration by upregulating MMP-2 and MMP-9 production via PI3K/AKT pathway. PMID: 27470388
  27. CXCR3 expression in chronic lymphocytic leukemia cells was a strong determinant of a worse clinical outcome. PMID: 26589908
  28. Speculate that aberrant expression of CXCR3 in marginal zone lymphoma of the skin is associated with migration of lymphoma cells to the epidermis and could lead to an epidermotropic pattern. PMID: 26275313
  29. CXCR3 role in autoimmune thyroiditis [review] PMID: 24999582
  30. Both CXCL10 and CXCR3 appeared to be useful in differentiating T1R reaction in borderline leprosy while CXCR3 alone differentiated BT from BT-T1R PMID: 26831417
  31. CXCR3 expression was upregulated in advanced gastric cancer and was associated with increased CD4+, CD8+ tumor-infiltrating lymphocyte infiltration and improved overall survival PMID: 26823797
  32. CXCR3 was also linked to steatosis through inducing hepatic lipogenic genes PMID: 26394162
  33. congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP. PMID: 26506526
  34. Suggest that aberrant CXCR3 expression may play crucial roles in suppressing prostate carcinoma metastasis by inhibiting cell proliferation and invasion through the PCLbeta signaling pathway. PMID: 26339376
  35. The expression of the chemokine receptors CXCR3, CXCR4 and CXCR7 and their ligands. PMID: 26037167
  36. This study is aimed at the optimization of a new analytical method for metabolic profiling with parallel bioaffinity assessment of CXCR3 ligands of the azaquinazolinone and piperazinyl-piperidine class and their metabolites. PMID: 26164305
  37. CXCR3-A, the predominant form in hematopoietic cells, mediates tumor "go" signaling by promoting cell proliferation, survival, chemotaxis, invasion and metastasis; while CXCR3-B, on epithelial cells, mediates "stop" signaling PMID: 25663474
  38. Common variants of CXCR3 and its ligands CXCL10 and CXCL11 are associated with vascular permeability of dengue infection in peninsular Malaysia. PMID: 25858769
  39. our study suggested a potential use of CXCR3 overexpression as a prognostic marker for gastric cancer PMID: 26434630
  40. CD4+ T cells demonstrated markedly decreased CXCR3 expression. PMID: 25768944
  41. Results indicate that CXC chemokine receptors 3 (CXCR3) contributes to spontaneous preterm birth (SPTB). PMID: 26209629
  42. High expression of CXCR3 is associated with glioblastoma patients with an invasive phenotype. PMID: 25527046
  43. Report crosstalk between TGF-beta1 and CXCR3 signaling in the regulation of urethral fibrosis. PMID: 24907118
  44. Expression of CXCR3 in fibroblasts is associated with the expression of IL-13Ralpha2. PMID: 25514189
  45. Targeting of both CXCR3 isoforms may be important to block the stem cell-promoting actions of CXCR3-B, while inhibiting the pro-proliferative and metastasis-promoting functions of CXCR3-A. PMID: 25537642
  46. CXCR3 has been demonstrated to be strongly related to tumour progression in advanced colorectal cancer. PMID: 25232565
  47. CXCR3 and IP-10 are involved in the pathogenesis of bronchiolitis, and CXCR3 is associated with allergic factors. PMID: 25760840
  48. Higher percentages of CCR4+ CD4 TEM cells in acute RSV infection were accompanied with higher percentages of CXCR3+ CD8 TEM cells, whereas the development of long-lived memory CXCR3+ CD4 and CD8 TCM cells seems to be compromised PMID: 25013801
  49. the participation of the chemokine CXCL10/CXCR3 axis in celiac disease pathogenesis PMID: 24586509
  50. The different groups of clinically stable nonallergic asthmatic patients showed distinct patterns of alterations in subset distribution as well as CCR6, CXCR3, and CCR5 expression on circulating T lymphocytes. PMID: 25178112
  51. plays a role in insulin resistance and obesity-induced visceral adipose inflammation PMID: 24124129
  52. We show here for the first time that CXCL10 and CXCR3 expression are both predictors of favorable outcome in patients treated with tamoxifen. PMID: 24715380
  53. The CXCR3 polymorphism rs34334103 was associated with male gender and pleuritis in patients with SLE. PMID: 24530757
  54. CXCR3 interacts with CXCL11 on brain microvascular endothelial cells. PMID: 24526602
  55. Post-transplant enhanced CXCL10/CXCR3 signaling in small-for-size liver grafts directly induced endothelial progenitor cell mobilization PMID: 23994383
  56. interfering with IL-1beta and IL-12 signaling in Th17 cells during inflammation may be a promising therapeutic approach to reduce their differentiation into "pathogenic" CCR6+ CXCR3+ Th1/17 cells in patients with autoimmune diseases. PMID: 24890729
  57. CXCR3, CXCR4, CXCR7 have similar transmembrane helices, different conformations of N-terminal, C-terminal regions and extracellular loops, and interaction between the three receptors and CXCL11 and CXCL12 are on a hydrophobic and electrostatic basis. PMID: 23773308
  58. Both EMAP II and CXCR3 were essentially required for gp120-induced lung microvascular endothelial cell apoptosis. PMID: 24318111
  59. CXCR3-B mediates a growth-inhibitory signal in breast cancer cells through the modulations of nuclear translocation of Bach-1 and Nrf2 and down-regulation of HO-1. PMID: 24366869
  60. CCR5-Delta32 polymorphism and CXCR3/CCR5 underexpression influence downregulation of the corresponding receptors in TILs. PMID: 24129241
  61. Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection. PMID: 23643635
  62. Pericytes regulate angiogenic vessel formation, and this is mediated through CXCR3 expressed on endothelial cells. PMID: 24135023
  63. CXCL10 and CXCR3 were upregulated in colonic mucosa in active inflammatory bowel disease (IBD). The TLR3-ligand poly(I:C) increased release of CXCL10 in colonic epithelial cell lines, suggesting a TLR3-mediated CXCL10 release in IBD patients. PMID: 22685032
  64. Data suggest that co-expression of CCX-CKR (atypical chemokine receptor 4) and CXCR3 in T-lymphocytes results in protein multimerization and prevents CXCR3-mediated chemotaxis; this represents a novel mechanism of regulation of immune cell migration. PMID: 23121557
  65. CXCR3 promotes recruitment of Th17 cells from the blood into the liver in both human and murine liver injury. Their subsequent positioning near bile ducts is dependent on CCR6 and cholangiocyte-secreted CCL20. PMID: 22796894
  66. CXCR3 expression on CD4(+) T cells was fivefold higher in those from CSF than blood, but was not increased in paediatric opsoclonus-myoclonus syndrome. PMID: 23600831
  67. CXCR3 expression was higher in immune thrombocytopenic purpura patients (prior to treatment and in remission) than in healthy controls. PMID: 23158864
  68. Data indicate that women with systemic lupus erythematosus (SLE) responded similar to pregnancy as did healthy women with lower percentages of CCR2+, CCR5+ and CXCR3+ monocytes. PMID: 23298254
  69. Intra-hepatic accumulation of the functionally impaired CXCR3(+)CD56Bright NK cell subset might be involved in HCV-induced liver fibrosis. PMID: 22792160
  70. Bortezomib significantly decreases CXCR3 expression on T cells & their CD4(+)/CD8(+) subsets in a dose-dependent manner. PMID: 23179902
  71. Both CXCR3 and CXCR4 are involved in metastasis of colorectal cancer to lymph nodes, lungs and liver. PMID: 22689289
  72. CCR4-, CCR5-, CXCR3-, and selectin ligand-expressing CD4+ T cells preferentially accumulate in the joints of children with juvenile idiopathic arthritis. PMID: 21739422
  73. Protein nitration was required for CXCR3 receptor up-regulation by cigarette smoke and for CXCR3-induced cell death. PMID: 22936405
  74. We describe and characterize a new autocrine/paracrine role of CXCL10/CXCR3 in the regulation of fibroblast-like synoviocyte invasion in rats with arthritis and in rheumatoid arthritis patients. PMID: 21811993
  75. high level of CXCR3 protein expression was significantly associated with tumor differentiation, tumor size, lymph node metastasis, distant metastasis, and Dukes' classification in patients with colorectal carcinoma PMID: 22401929
  76. natural CXCR3(+) T-bet(+) Treg selectively accumulate in ovarian tumors to control type I T-cell responses, resulting in the collateral limitation of efficient antitumor immunity. PMID: 22798340
  77. Chemokine gene-expression patterns were consistent with an angiogenic-angiostatic imbalance and a downregulation of CXCR3 receptor-mediated signaling in the PCs from obese subjects. PMID: 22262158
  78. The chemokine CXCL12, its truncated form SDF-1(5-67), and the receptors CXCR4 and CXCR3 are expressed in human glaucomatous trabecular tissue and a human trabecular cell line. PMID: 22675496
  79. CXCR3 expression was associated with epidermotropic T cell tumors but was greatly absent in dermal ones. Scattered or diffuse CD30 expression in transformed mycosis fungoides was not associated with an absence of CXCR3 expression. PMID: 22369302
  80. aberrant expression of CXCR3A and down-regulation of CXCR3B may switch a progression "stop" to a "go" signal to promote prostate tumor metastasis via stimulating cell migration and invasion. PMID: 22236567
  81. CXCR3 agonist induces receptor cross-phosphorylation within CXCR3-CCR5 heterodimers on the surface of activated T cells PMID: 22392992
  82. The data supported a role for CCR5, CXCR3, and CXCR6 in the selective recruitment of T cells into renal cell carcinoma tissue and, together with CCR6, in the recruitment of regulatory T cells. PMID: 22079021
  83. Elevated plasma levels of interferon-gamma and Cys-X-Cys chemokine receptor 3-binding chemokines are present in patients with thoracic aortic aneurysms. PMID: 21962843
  84. CD8(+) lymphocytes from HIV/HCV-infected patients expressed more CXCR3 and showed greater upregulatory ability upon activation. PMID: 22111598
  85. These results show that while the expression of MIG/CXCL9 and IP-10/CXCL10 are elevated in Systemic sclerosis (SSc) serum, the expression of CXCR3 is downregulated on SSc dermal Endothelial cells. PMID: 21303517
  86. Suggest decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients may contribute to reduced antitumor immune function. PMID: 21357438
  87. expression of CXC chemokine receptor 3 is reduced with continuous exposure to asbestos in a human T-cell line, MT-2 PMID: 21148743
  88. The interactions between CXCL9, CXCL10 and CXCL12 expressed in decidua and villi and CXCR3, CXCR4 expressed in CD(56)(+) decidua NK cells may influence the CD(56)(+)NK cell recruitment at the maternal-fetal interface. PMID: 19134328
  89. CXCR3 was up-regulated in breast cancer and was associated with disease progression. PMID: 21426802
  90. CXCR3 ligands, CXCL9,10,11, are differentially expressed during chronic liver diseases across different disease stages and aetiologies. PMID: 21645215
  91. Results demonstrate that the peripheral homing receptor CXCR3 is expressed on subset(s) of circulating Tregs and suggest a role for CXCR3 in their recruitment into peripheral sites of inflammation. PMID: 21538345
  92. Suggest that the renal TWEAK/Fn14 and IP-10/CXCR3 axis may contribute to the pathogenesis of lupus nephritis. PMID: 21303425
  93. Results demonstrated the expression of CXCR3 as well as of two of its known variants, CXCR3-B and CXCR3-alt, in ex vivo activated T lymphocytes. PMID: 21255008
  94. suggesting that gliadin-induced IL-8 production was CXCR3-dependent gliadin induced IL-8 production only in coeliac disease PMID: 21091908
  95. CXCR3 antagonism exerts a direct anti-glioma effect and this receptor may be a potential therapeutic target for treating human glioma. PMID: 21051441
  96. Down-regulation of CXCR3-B is associated with renal cancer. PMID: 20855888
  97. both CXCR3A and CXCR3B are implicated in the chemotactic and vascular effects of CXCL4L1. PMID: 20980681
  98. this study provides evidence of the significant overexpression of the CXCR3 axis in active IBD, suggesting it has a role in IBD pathogenesis. PMID: 20848514
  99. CXCL10 inhibits endothelial cell proliferation independently of CXCR3. PMID: 20856926
  100. Increased numbers of immature plasma cells may migrate towards inflammatory sites of ulcerative colitis (UC) via the CXCR3 axis, and may participate in UC pathogenesis. PMID: 21087446

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Subcellular Location Isoform 1: Cell membrane, Multi-pass membrane protein, SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Database Links

HGNC: 4540

OMIM: 300574

KEGG: hsa:2833

STRING: 9606.ENSP00000362795

UniGene: Hs.198252

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