Code | CSB-CF006253HUb0 |
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Size | $1040 |
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The recombinant Human CXCR3 protein is a cell-free system in vitro E.coli expressed Full Length protein. In cell-free systems, synthesis of the protein can be carried out in vitro using extracts of whole cells that are compatible with translation. These cell extracts contain all the molecules and enzymes that are needed to transcribe, translate, and post-translationally modify the recombinant protein. With additional supplements of cofactors, CXCR3 proteins can be formed in a few hours. However, this system may not be applicable for the large-scale production of recombinant proteins. Advantages of this system include that proteins can be synthesized without cell culturing; also, it is possible to express many proteins together.
CXCR3, also called GPR9 or CD183, is an interferon (IFN)-gamma inducible chemokine receptor selectively expressed on monocytes, Th1 T cells, CD8 T cells, NKT cells, NK cells, dendritic cells, and some tumor cells. CXCR3 and its ligands, CXCL9, CXCL10, and CXCL11 are key immune chemoattractants during interferon-induced inflammatory responses and play a crucial role in the activation, differentiation, and effector T cell function. CXCR3/ligand interactions exert a dual role in tumor progression and immunity. CXCR3/ligand axis affects the tumor microenvironments (TME) by regulating angiogenesis, recruiting activated immune cells, and influencing tumor cells in divergent roles either by promoting or inhibiting tumor progression.There are currently no reviews for this product.