ACTH (Lu AG13909 Biosimilar) Recombinant Monoclonal Antibody

1. These findings show that POMC methylation status in the blood of children is associated with metabolic profiles. Therefore, we suggest that the DNA methylation status might serve as a potential epigenetic biomarkers of metabolic syndrome. PMID: 29598821
2. Herein, we summarise evidence supporting the potential candidacy in this light of alpha-melanocyte stimulatory hormone, an endogenous peptide hormone and a breakdown product of the neuropeptide pro-opiomelanocortin PMID: 29412826
3. Data suggest that the stress of intermittent hypoxia up-regulates expression of mRNA and protein for POMC and CART in neuronal cell lines; GATA2 and GATA3 appear to be involved in these stress mechanisms. (POMC = proopiomelanocortin; CART = cocaine- and amphetamine-regulated transcript protein; GATA2 = endothelial transcription factor GATA-2; GATA3 = T-cell-specific transcription factor GATA-3) PMID: 29275211
4. Mutation in POMC gene is associated with severe obesity, hypothyroidism, adrenal insufficiency and abnormal reddish hair pigmentation. PMID: 29858905
5. In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC pathway, employing PPARgamma as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma. PMID: 29020973
6. The human beta-endorphin amyloid was studied in detail, exploiting solid-state NMR spectroscopy and TEM analyses. PMID: 28075583
7. POMC and MC1R were significantly lower in vitiligo lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls. PMID: 26437741
8. POMC has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets. PMID: 27273100
9. E2F1-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome. PMID: 27935805
10. Elevated ACTH secretion is associated with Cushing's syndrome. PMID: 28328532
11. a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. PMID: 27885802
12. Data suggest that alpha-MSH enhances cell adhesion to fibronectin in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF, IL-6 and IL-8) in such synoviocyte cultures. PMID: 27396757
13. Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1, SF-1, and ACTH. PMID: 27227698
14. The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population. PMID: 26226973
15. The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB. PMID: 26513428
16. Low circulating plasma alpha-MSH levels are associated with obesity. PMID: 26758700
17. hsa-miR-34a can regulate the CRH/CRHR1/POMC axis and may influence body mass index. PMID: 26940669
18. ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis. PMID: 26084546
19. the inhibitory effects of alpha-MSH on inflammation are dependent on MC-1 R PMID: 25898835
20. the low circadian alpha-MSH levels observed in AN integrate the adaptive profile of appetite regulation of this disease PMID: 25798605
21. CSF POMC was higher in lean vs. overweight/obese subjects. PMID: 26152765
22. There was a non-linear association between leukocyte telomere length and plasma ACTH after laboratory stressor in elderly adults. PMID: 25622010
23. Synovial fluid alpha-MSH levels showed an independent and negative correlation with articular cartilage degeneration in patients with knee ACL deficiency. PMID: 26427140
24. This study suggest the involvement of genetic variants of POMC in the outcome of antidepressant treatment in patients with MDD, and indicate the possibility of an interaction of this association with stressful life events. PMID: 25448875
25. Term infants born with meconium-stained amniotic fluid (MSAF) and who experienced respiratory distress had significantly lower levels of ACTH and cortisol at birth compared with well term infants born with MSAF or clear amniotic fluid. PMID: 25205705
26. POMC-positive expression is a novel, independent poor prognostic marker. PMID: 25377161
27. the hypothalamic proopiomelanocortin neurons, have a key role in the control of food intake and energy metabolism. PMID: 24732669
28. Report clinicopathological/immunohistochemical features of ACTH-secreting pancreatic neoplasms. PMID: 25353285
29. This work shows that the AR and the POMC gene might functionally interact with each other and subsequently mediate craving in alcohol-dependent patients. PMID: 24271034
30. Expanding upon previous observations of high POMC in ectopic ACTH syndrome, this study specifically demonstrates elevated POMC levels can identify occult ectopic tumors. PMID: 25013995
31. 9-cis retinoic acid decreased the steady-state level of the ACTH precursor proopiomelanocortin. PMID: 24926820
32. POMC SNPs (rs6713532, rs1047521, rs3754860) were not associated with antipsychotic-induced weight gain in schizophrenia patients. PMID: 24564533
33. Data suggest that CLOCK proteins are involved in regulation of ACTH and cortisol secretion under non-stressful conditions to maintain homeostasis in the hypothalamic-pituitary-adrenal axis as well as in response to stressful conditions. [REVIEW] PMID: 23933687
34. these results indicate that HDGF downregulation participates in POMC-induced suppression of metastasis and EMT in melanoma. PMID: 23468531
35. ACTH induced cAMP production and increased AR nuclear labeling in immunocytochemical assays. PMID: 22842514
36. Data suggest that optimistic attitude/psychological intervention helps cancer patients survive longer via increase in beta-endorphin neuronal suppression of stress hormone levels and activation of innate immune cells destroying tumor cells. [REVIEW] PMID: 23810011
37. It can be concluded from this study that the basal plasma beta endorphin level was low in migraine patients PMID: 23314782
38. human dermal fibroblasts express only truncated/alternatively spliced POMC mRNA variants PMID: 23218956
39. Functional heterogeneity of hypothalamic arcuate nucleus (ARC) POMC neurons reveals distinct subpopulations of POMC cells activated by 5-HT2CRs and disinhibited by 5-HT1BRs. PMID: 23739976
40. Finally, the results from our patient strongly suggest that the absence of red hair in non-European patients with early-onset obesity and ACTH deficiency does not exclude the occurrence of POMC-inactivating mutations. PMID: 22612534
41. A POMC mutation, found in a patient with early-onset type 2 diabetes and central obesity, segregated in the family and was associated with overweight, type 2 diabetes, hypertension and coronary heart disease in the carriers. PMID: 22643178
42. The expression of beta-endorphin is high in hypertrophic scars, it may play an important role in pruritus. PMID: 22792774
43. POMC neurons regulate feeding and energy homeostasis by integrating long-term adiposity signals from the hypothalamus and short-term from the brainstem. PMID: 23426689
44. Eexpression of alpha-MSH may markedly increase in the split-thickness grafted skin and correlate with its pigmentation after the skin graft. PMID: 15835810
45. NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes. PMID: 23224873
46. Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance. PMID: 23118421
47. Findings suggest that POMC exonic variants may influence risk for both substance dependence and elevated BMI, in a population-specific manner. PMID: 23028917
48. POMC promoter-specific DNA methylation was not affected by diagnosis or nutritional status but significantly negatively associated with cigarette smoki PMID: 22398003
49. This review summarizes the role of leptin and serotonin receptors in regulating the activity of POMC neurons, providing a model in which different melanocortin pathways regulate energy and glucose homeostasis. PMID: 22328135
50. Genetic disruption of polysialic acid-mediated signaling limits behavioral and metabolic adaptation to the high-fat diet (HFD), as treated transgenic mice fail to normalize energy intake and show increased body weight gain after HFD challenge. PMID: 22933782

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HGNC: 9201

OMIM: 176830

KEGG: hsa:5443

STRING: 9606.ENSP00000264708

UniGene: Hs.1897