CAPRIN1 (TRK-950 Biosimilar) Recombinant Monoclonal Antibody

1. that high Caprin1 expression was significantly associated with worse overall survival for patients with hepatocellular carcinoma PMID: 29037839
2. Based on insights from the structures and existing biochemical data, the existence of an evolutionarily conserved ribonucleoprotein (RNP) complex consisting of Caprin-1, FMRP and G3BP1 is proposed. PMID: 27303792
3. Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line. PMID: 28733330
4. G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10. PMID: 27022092
5. The G3BP1-Caprin1-PKR complex represents a new mode of PKR activation and is important for antiviral activity of G3BP1 and PKR during infection with mengovirus. PMID: 25784705
6. Data show that tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex. PMID: 25669982
7. G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. PMID: 24992036
8. Cyr61/Caprin-1 co-expression was associated with worse survival. PMID: 23528710
9. These results suggest that the Japanese encephalitis virus core protein circumvents translational shutoff by inhibiting stress granule formation through an interaction with Caprin-1 and facilitates viral propagation in vitro and in vivo. PMID: 23097442
10. Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes PMID: 22737234
11. Homologous region-1 (HR-1) is a novel protein domain that has been identified near the N-terminus of human caprin-1; highly conserved in vertebrates and insects, it is also present in the human caprin-2 paralog. PMID: 14764709
12. involvement of cellular protein p137 in transcription of intermediate stage genes may regulate the transition between early and late phases of vaccinia virus replication PMID: 15471883
13. Suppression of expression of human Caprin-1 results in slowing of the proliferation rate, due to prolongation of the G1 phase of the cell cycle, formally demonstrating that Caprin-1 is essential for normal cellular proliferation. PMID: 16177067
14. Caprin-1/G3BP-1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons PMID: 17210633
15. MiR-16 negatively regulate HMGA1 and caprin-1 which are involved in cell proliferation. PMID: 19250063

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HGNC: 6743

OMIM: 601178

KEGG: hsa:4076

STRING: 9606.ENSP00000340329

UniGene: Hs.471818