CD6 (Itolizumab Biosimilar) Recombinant Monoclonal Antibody

1. This study provides evidence that CD6 is involved in the susceptibility to Behcet's disease in a Chinese Han population. PMID: 27108704
2. These results suggest that (i) CD6 is a negative regulator of T-cell activation, (ii) at the same time, CD6 is a positive regulator of activated T-cell survival/proliferation and infiltration; and (iii) CD6 is a potential new target for treating multiple sclerosis (MS)and potentially other T-cell-driven autoimmune conditions. PMID: 28209777
3. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. PMID: 28289074
4. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides. PMID: 27896837
5. Results from recent genetic association studies provide evidence for a role of CD6 in multiple sclerosis and in rheumatoid arthritis pathogenesis. [review] PMID: 26844569
6. Study provides evidence on the role of CD6, a lymphocyte-specific surface receptor from to the ancient and highly conserved Scavenger Receptor Cysteine-Rich (SRCR) superfamily, as a pattern recognition receptor, and the functional consequences this may have on T cell activation and differentiation. [review] PMID: 25777272
7. Data show the multiple aspects that determine the nature of the signals transmitted via CD6 and the context that may define a dual role for this important T cell surface molecule. [review] PMID: 26028048
8. Data show a role for extracellular and intracellular interactions of CD6 in lateral movement in response to T cell activation. [review] PMID: 26302795
9. The binding sites on CD6 and CD166 have been characterized to show that a SNP in CD6 causes glycosylation that hinders the CD6/CD166 interaction. PMID: 26146185
10. CD6 regulatory T cells are characterized by CD6 expression and FOXP3 expression. PMID: 25088497
11. interaction of Galectin-1 and -3 with CD6 PMID: 24945728
12. upon T cell activation, SRSF1 becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation. PMID: 24890719
13. The CD6 polymorphism conferred reduced odds of optic neuritis as an attack location PMID: 24130718
14. In a Korean population, one SNP in CD6 was associated with neuromyelitis optica. PMID: 22994200
15. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4(+) and CD8(+) T cells. PMID: 23638056
16. A novel level of regulation of CD6 function by intracytoplasmic serine phosphorylation. PMID: 23711376
17. Data suggest that genetic variations within CD6 and syntaxin binding protein 6 (STXBP6) may influence response to TNFalpha inhibitors in patients with rheumatoid arthritis (RA). PMID: 22685579
18. Cd6 is a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells. PMID: 21956609
19. These findings indicate that the multiple sclerosis risk allele in the CD6 locus is associated with altered proliferation of CD4(+) T cells PMID: 21849685
20. CD6 expression on peripheral NK cells marks a novel CD56(dim) subpopulation associated with distinct patterns of cytokine and chemokine secretion. PMID: 21178331
21. association of single nucleotide polymorphisms to multiple sclerosis PMID: 21552549
22. CD6+ B cells are diminished in Sjogren's syndrome PMID: 20810246
23. Data show that CD6-ALCAM interaction in vitro induced a synergistic co-stimulation of normal peripheral blood mononuclear cells. PMID: 20726988
24. Study reinforces a role for CD6 and TNFRSF1A as risk loci for multiple sclerosis, extending to populations of southern European ancestry. PMID: 20430450
25. CD6 associates with the scaffolding PDZ-containing protein syntenin-1 during maturation of the immunological synapse PMID: 16034076
26. Engagement of CD6 with CD166 on tumor cells plays an important role in gammadelta T cell activation by tumor cells sensitized with nonpeptide antigens endogenously or exogenously. PMID: 16818742
27. the CD6-ALCAM interaction results in activation of the three MAP kinase cascades, likely influencing the dynamic balance that determines whether resting or activated lymphocytes survive or undergo apoptosis. PMID: 16818773
28. The costimulatory effect of CD6 is mediated through phosphorylation-dependent binding of a specific tyrosine residue, 662Y, in its cytoplasmic region to the adaptor SLP-76. PMID: 16914752
29. Unprecedented bacterial binding properties of recombinant soluble CD6 support its therapeutic potential for the intervention of septic shock syndrome or other inflammatory diseases of infectious origin. PMID: 17601777
30. A chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. PMID: 18707547
31. Replication in an independent set of 2,215 subjects with multiple sclerosis (MS) and 2,116 control subjects validates new MS susceptibility loci at TNFRSF1A, IRF8 and CD6; TNFRSF1A harbors two independent susceptibility alleles. PMID: 19525953
32. Comprehensive profiling of the cell surface proteome provides an effective approach for the identification of commonly occurring proteins as well as proteins with restricted expression patterns in this compartment. PMID: 12493773

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HGNC: 1691

OMIM: 186720

KEGG: hsa:923

STRING: 9606.ENSP00000323280

UniGene: Hs.744366