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CEL (SOL-116 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA325708MB1HU
Size US$9799
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Product Details

Uniprot No.
P19835
Target Names
CEL
Alternative Names
CEL antibody; BAL antibody; Bile salt-activated lipase antibody; BAL antibody; EC 3.1.1.13 antibody; EC 3.1.1.3 antibody; EC 3.1.1.6 antibody; Bile salt-stimulated lipase antibody; BSSL antibody; Bucelipase antibody; Carboxyl ester lipase antibody; Cholesterol esterase antibody; Pancreatic lysophospholipase antibody; Sterol esterase antibody
Species Reactivity
Human
Immunogen
Recombinant Human CEL protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to SOL-116, targeting carboxylesterase liver (CEL), also known as bile salt-activated lipase (BSAL). CEL is a digestive enzyme primarily expressed in the pancreas and liver that plays a critical role in lipid metabolism by hydrolyzing cholesterol esters, triglycerides, and other lipid substrates in the intestinal lumen. This enzyme is essential for dietary fat absorption and has been implicated in various pathophysiological conditions, including pancreatic disorders, metabolic diseases, and certain malignancies. Mutations in the CEL gene are associated with maturity-onset diabetes of the young (MODY) and chronic pancreatitis, making it a relevant target for investigating digestive and metabolic dysfunction.

As a biosimilar to the reference antibody SOL-116, this reagent provides researchers with a reliable tool for investigating CEL expression, localization, and function in various experimental contexts. It supports studies examining pancreatic enzyme secretion, lipid digestion mechanisms, and the role of CEL in disease pathogenesis, offering valuable insights into digestive physiology and metabolic research.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

CEL Antibodies

CEL Proteins

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Target Background

Function
Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins.
Involvement in disease
Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8)
Subcellular Location
Secreted.
Protein Families
Type-B carboxylesterase/lipase family
Tissue Specificity
Mammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level). Expressed by eosinophils.
Database Links

HGNC: 1848

OMIM: 114840

STRING: 9606.ENSP00000361151

UniGene: Hs.533258

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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