FCRL5 (DFRF4539A (RG-7598) Biosimilar) Recombinant Monoclonal Antibody

1. based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand. PMID: 29101848
2. we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism PMID: 27065451
3. this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation PMID: 27076679
4. Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic. PMID: 25993340
5. FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. PMID: 23616577
6. FcRL5 binds all immunoglobulin (Ig)G isotypes with varied efficiency. PMID: 22491254
7. Enhanced proliferation and downstream isotype expression upon FCRL5 stimulation could reflect a physiological role for FCRL5 in the expansion and development of antigen-primed B cells. PMID: 22028333
8. Three of the FCRL5 tag SNPs, rs6667109, rs3811035 and rs6692977 showed association with Graves' disease. association with FCRL5 was secondary to linkage disequilibrium with the FCRL3, rs11264798 and rs10489678 SNPs. PMID: 20626413
9. Characterization and comparison of the structure and B-cell expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome. PMID: 11929751
10. IRTA2 is expressed on the surface of human lymphoma cell lines and hairy cell leukemia cells PMID: 15671532
11. results identify FcRH5 as a novel, direct target of EBNA2 that may contribute to the development of Epstein-Barr virus-associated tumors PMID: 16439682
12. IRTA2/FcRH5 may have a role in hairy cell leukemia PMID: 16681430
13. Down-regulation of FCRL5 is associated with acute lymphoblastic leukemia. PMID: 18802695
14. Single-nucleotide polymorphism in the FCRL5 gene and HLA-B27 is associated with ankylosing spondylitis. PMID: 19775371

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HGNC: 18508

OMIM: 605877

KEGG: hsa:83416

STRING: 9606.ENSP00000354691

UniGene: Hs.415950