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GRIN (ART-5803 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA982955MB1HU
Size US$9799
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Product Details

Uniprot No.
#N A
Target Names
GRIN
Alternative Names
ART-5803 research-grade biosimilar
Species Reactivity
Human
Immunogen
Recombinant Human GRIN protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to reference antibody ART-5803, targeting GRIN (Gremlin-1), a secreted glycoprotein member of the DAN family of BMP antagonists. GRIN functions as a critical regulator of bone morphogenetic protein (BMP) signaling by directly binding and inhibiting BMP-2, BMP-4, and BMP-7, thereby modulating cellular differentiation, proliferation, and tissue development. Through its antagonistic activity on BMP pathways, GRIN plays important roles in embryonic development, organogenesis, and tissue homeostasis. Dysregulated GRIN expression has been implicated in various pathological conditions, including fibrotic diseases, pulmonary arterial hypertension, diabetic nephropathy, and cancer progression, where it contributes to epithelial-mesenchymal transition, angiogenesis, and tumor microenvironment remodeling.

As a biosimilar to ART-5803, this antibody provides researchers with a reliable tool for investigating GRIN-mediated signaling mechanisms and its involvement in disease pathogenesis. It supports studies examining BMP pathway modulation, fibrosis development, vascular remodeling, and oncogenic processes across multiple research contexts.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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[email protected]
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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