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KLK (Lanadelumab Biosimilar) Recombinant Monoclonal Antibody

KLK (Lanadelumab Biosimilar) Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA035520MB1HU
Size	US$9799
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Product Details
Customer Reviews and Q&A

Product Details

Uniprot No.

#N A

Target Names

KLK

Alternative Names

Anti-plasma kallikrein mAb research-grade biosimilar; Anti-plasma kallikrein monoclonal antibody research-grade biosimilar; DX-2930 research-grade biosimilar; lanadelumab research-grade biosimilar; Lanadelumab (genetical recombination) research-grade biosimilar; Lanadelumab (genetical recombination) (JAN) research-grade biosimilar; Lanadelumab (USAN) research-grade biosimilar; Lanadelumab-flyo research-grade biosimilar; LANDELUMAB-FLYO research-grade biosimilar; SHP 643 research-grade biosimilar; SHP-643 research-grade biosimilar; TAK-743 research-grade biosimilar; Takhzyro research-grade biosimilar; X124-G01 research-grade biosimilar; 탁자이로주 research-grade biosimilar

Species Reactivity

Human

Immunogen

Recombinant Human KLK protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to lanadelumab, targeting plasma kallikrein (KLK), a serine protease that plays a central role in the contact activation system and kinin-kallikrein pathway. Plasma kallikrein cleaves high-molecular-weight kininogen to release bradykinin, a potent vasoactive peptide that increases vascular permeability and promotes inflammation. Dysregulated kallikrein activity and excessive bradykinin production are implicated in hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent episodes of severe swelling, as well as in other inflammatory and cardiovascular conditions.

Lanadelumab is a fully humanized IgG1 monoclonal antibody approved for prophylactic treatment of HAE that functions by inhibiting plasma kallikrein enzymatic activity. This biosimilar antibody provides researchers with a valuable tool for investigating kallikrein-bradykinin pathway mechanisms, studying angioedema pathophysiology, exploring contact system biology, and evaluating therapeutic strategies for bradykinin-mediated disorders. It supports studies examining protease inhibition, inflammatory cascades, and vascular permeability regulation in various experimental models.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Customer Reviews and Q&A

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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