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EGFR&LGR5 (Petosemtamab Biosimilar) Recombinant Monoclonal Antibody

EGFR&LGR5 (Petosemtamab Biosimilar) Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA012906MB1HU
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Product Details
Customer Reviews and Q&A

Product Details

Uniprot No.

P00533&O75473

Target Names

EGFR&LGR5

Alternative Names

FEX antibody; G protein coupled receptor 49 antibody; G protein coupled receptor 67 antibody; g protein-coupled receptor fex antibody; G-protein coupled receptor 49 antibody; G-protein coupled receptor 67 antibody; G-protein coupled receptor HG38 antibody; GPCR GPR49 antibody; GPR 49 antibody; GPR 67 antibody; GPR49 antibody; GPR67 antibody; GRP 49 antibody; GRP49 antibody; HG 38 antibody; HG38 antibody; Leucine rich repeat containing G protein coupled receptor 5 antibody; Leucine-rich repeat-containing G-protein coupled receptor 5 antibody; LGR 5 antibody; LGR5 antibody; LGR5_HUMAN antibody; MGC117008 antibody; Orphan G protein coupled receptor HG38 antibody

Species Reactivity

Human

Immunogen

Recombinant Human EGFR&LGR5 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems. Guaranteed Quality ① Antibody purity > 95% tested by SDS-PAGE. ② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to Petosemtamab, targeting LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5), a critical stem cell marker and Wnt signaling modulator. LGR5 serves as a receptor for R-spondins and acts as a key regulator of tissue homeostasis by amplifying Wnt/β-catenin signaling pathways. This protein is predominantly expressed in adult stem cells within rapidly renewing tissues, including the intestinal crypts, hair follicles, and stomach. Aberrant LGR5 expression has been implicated in multiple cancers, where it marks cancer stem cell populations in colorectal, gastric, ovarian, and pancreatic malignancies, making it a significant therapeutic target for oncology research.

Petosemtamab represents a bispecific antibody format that has been investigated in clinical trials for advanced solid tumors, particularly those with high LGR5 expression. This biosimilar antibody provides researchers with a valuable tool for investigating LGR5-mediated signaling mechanisms, cancer stem cell biology, tissue regeneration processes, and potential therapeutic interventions in LGR5-expressing tumors.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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