LINGO1 (Opicinumab Biosimilar) Recombinant Monoclonal Antibody

1. We identified homozygous missense variants in LINGO1, p.(Arg290His) in family F162 and p.(Tyr288Cys) in family PKMR65. Both variants were predicted to be pathogenic, and segregated with the phenotype in the respective families. Molecular modeling of LINGO1 suggests that both variants interfere with the glycosylation of the protein. PMID: 28837161
2. LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Chinese population. PMID: 26254004
3. LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells. PMID: 26979953
4. The results of this study show Increased LINGO1 in the cerebellum of essential tremor patients. PMID: 24531928
5. Lingo-1 signaling is altered in the schizophrenia brain. PMID: 24448210
6. LINGO-1 can directly bind to ErbB2, block ErbB2 translocation into lipid rafts, and inhibit its phosphorylation. PMID: 24583087
7. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor. PMID: 23682623
8. LINGO1 variants are associated with essential tremor in Chinese Han female patients. PMID: 23754655
9. This study demonistrated that theLINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis. PMID: 23574883
10. Results of a meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and risk of essential tremor (ET) and familial ET, while rs9652490 polymorphism is only associated with the risk for familial ET. PMID: 22425540
11. the N-terminal region containing the leucine-rich repeats along with the transmembrane and cytoplasmic domains of LINGO-1 are not required for self-interaction or interaction with amyloid precursor protein PMID: 22133804
12. the present meta-analysis does not support the notion that LINGO1 rs9652490 SNP is a major genetic risk factor for parkinson disease.[meta-analysis] PMID: 22710005
13. This study showed that LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease. PMID: 21955595
14. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions PMID: 22514275
15. There were no significant differences in frequencies for all alleles between the essential tremor (ET) group and controls; however, an association of genotype A/G of the SNP rs9652490 with the familial ET phenotype was found. PMID: 21741293
16. Single nucleotide polymorphism(SNP)s of LINGO1 play a role in the development of Parkinson's disease in the Italian population. PMID: 21752692
17. LINGO1 variants are not a major risk factor for developing familial essential tremor in this population, which suggests the existence of other genetic risk factors responsible for familial essential tremor in this movement disorder clinic population. PMID: 21219542
18. while there were no significant differences in the Lingo1 minor allele frequency and genotype frequency between Chinese essential tremor and controls, pooled analysis showed a higher proportion of GG genotype in tremor patients PMID: 21158743
19. No significant differences are found in genotype and allele distribution in the rs9652490 variant of LINGO1 in either Chinese or Caucasian Parkinson disease patients. PMID: 20951767
20. This study demonistrated that LINGO1 variants could increase risk of PD, specifically those presenting the non-rigid-akinetic phenotypes, which suggests that LINGO1 may have a role in the etiology of tremor in PD at least in the Spanish population. PMID: 21506150
21. genotyping results lead us to conclude that no association exists between the key variant rs9652490 and Essential tremor (P(corr) = 1.00). PMID: 21264305
22. LINGO1 variant rs9652490 (A > G) is unlikely to play a major role in Parkinson's disease in Chinese populations. PMID: 20957646
23. LINGO-1 inhibits multiple aspects of oligodendrocyte differentiation independently of the LRRs via a process that requires p75(NTR) signalling PMID: 20659559
24. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease PMID: 20369371
25. The two markers rs9652490 and rs11856808 were not strongly related to the essential tremor,late onset sporadic Parkinson's disease, but the rs9652490G allele might be a protective factor for the early onset Parkinson's disease in Chinese population. PMID: 20600614
26. The LINGO1 gene is a risk factor for essential tremor in a Caucasian population in North America. PMID: 20372186
27. Our study gives further evidence that LINGO1 acts as a susceptibility gene for essential tremor. PMID: 20310002
28. Thisdy demonstrateda significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases. PMID: 19720553
29. LINGO1 SNP (rs9652490) is not associated with sporadic PD in our Polish cohort. PMID: 20117178
30. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and Parkinson disease. PMID: 19908305
31. The LERN1 expression pattern is specific to the central nervous system, highly and broadly expressed during early stages of development and gradually restricted to forebrain structures as development proceeds(LERN1) PMID: 14686891
32. the Lingo-1 ectodomain is a module implicated in central nervous system repair inhibition PMID: 17005555
33. inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration PMID: 17726113
34. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. PMID: 19182806
35. Quick identification of essential N-glycosylation sites of a heavily glycosylated neuroglycoprotein Lingo-1, which are sufficient for the support of its surface expression. PMID: 19254717
36. the LINGO1 gene is associated with an increased risk for essential tremor PMID: 19553813
37. LINGO1 variant increases risk of familial essential tremor. PMID: 19805735

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HGNC: 21205

OMIM: 609791

KEGG: hsa:84894

STRING: 9606.ENSP00000347451

UniGene: Hs.656765