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SLC39A12 (APL-9796 Biosimilar) Recombinant Monoclonal Antibody

SLC39A12 (APL-9796 Biosimilar) Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA706511MB1HU
Size	US$9799
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Product Details
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Target Background

Product Details

Uniprot No.

Q504Y0

Target Names

SLC39A12

Alternative Names

AP13 research-grade biosimilar; APL9796 research-grade biosimilar; APL 9796 research-grade biosimilar; humanized monoclonal antibody directed against human zinc-regulated transporter-like, iron-regulated transporter-like protein 12 research-grade biosimilar ;SLC39A12 antibody; ZIP12 antibody; Zinc transporter ZIP12 antibody; LIV-1 subfamily of ZIP zinc transporter 8 antibody; LZT-Hs8 antibody; Solute carrier family 39 member 12 antibody; Zrt- and Irt-like protein 12 antibody; ZIP-12 antibody

Species Reactivity

Human

Immunogen

Recombinant Human SLC39A12 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to the reference antibody APL-9796, specifically targeting SLC39A12 (solute carrier family 39 member 12), also known as ZIP12. SLC39A12 functions as a zinc transporter protein that facilitates the cellular uptake of zinc ions across the plasma membrane, playing a critical role in maintaining zinc homeostasis within cells. This transporter is particularly relevant in metabolic regulation and has been implicated in various pathological conditions including obesity, insulin resistance, type 2 diabetes, and Alzheimer's disease. Aberrant expression of SLC39A12 has also been associated with certain cancers and neurodegenerative disorders, where altered zinc metabolism contributes to disease progression.

As a biosimilar to APL-9796, this antibody provides researchers with a reliable tool for investigating SLC39A12 expression patterns, cellular localization, and functional roles in various biological contexts. It serves as a valuable reagent for studies examining zinc homeostasis mechanisms, metabolic disease pathways, and the therapeutic potential of targeting zinc transporters in human disease models.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Customer Reviews and Q&A

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Target Background

Function

Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.

Gene References into Functions

Data indicate that the zinc transporter ZIP12 (slc39a12) is highly expressed in brain. PMID: 23716681
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
Examination of the zinc transporter gene, SLC39A12. PMID: 16311021
Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451
Observational study of gene-disease association. (HuGE Navigator) PMID: 19064571

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

ZIP transporter (TC 2.A.5) family

Tissue Specificity

Expressed in brain and eye.

Database Links

HGNC: 20860

OMIM: 608734

KEGG: hsa:221074

STRING: 9606.ENSP00000366586

UniGene: Hs.350895

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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