Name: TAFA5 (NS-101 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA773595MB1HU

Product Details

Uniprot No.

Q7Z5A7

Target Names

TAFA5

Alternative Names

NS101(Neuracle Science) research-grade biosimilar; RY103 research-grade biosimilar; RY-103 research-grade biosimilar ;TAFA5 antibody; FAM19A5 antibody; UNQ5208/PRO34524 antibody; Chemokine-like protein TAFA-5 antibody

Species Reactivity

Human

Immunogen

Recombinant Human TAFA5 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is a research-grade biosimilar of NS-101, targeting TAFA5 (also known as FAM19A5)—a secreted, chemokine-like neurokine that is predominantly detected in the central and peripheral nervous systems. TAFA5/FAM19A5 has been implicated in regulating neural circuit and synapse-related biology, and has been explored as a mechanistic node in synaptic dysfunction associated with neurodegenerative and sensorineural disorders.

NS-101 is an anti-FAM19A5 monoclonal antibody being developed to restore synapse function, with clinical evaluation reported in contexts such as sudden sensorineural hearing loss (SSNHL) and exploratory neurodegenerative indications. Preclinical studies have reported that NS101 treatment is associated with improved synaptic electrophysiology and cognitive readouts in Alzheimer’s disease models, supporting its use as a tool for probing TAFA5/FAM19A5-linked synapse biology. This biosimilar provides the antibody component alone, enabling researchers to investigate TAFA5/FAM19A5 biology, target engagement, and downstream synapse-related mechanisms in controlled experimental systems, independent of clinical formulation variables.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries.

Subcellular Location

Secreted.

Protein Families

FAM19/TAFA family

Tissue Specificity

Expressed in the subcutaneous and perirenal adipose tissue (at protein level). Highly expressed in adipose tissue with moderate expression in the brain and ovary. Isoform 2: Brain-specific.

Database Links

HGNC: 21592

OMIM: 617499

KEGG: hsa:25817

STRING: 9606.ENSP00000383933

UniGene: Hs.436854

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Code	CSB-RA773595MB1HU
Size	US$9799
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TAFA5 (NS-101 Biosimilar) Recombinant Monoclonal Antibody

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Target Background