TEK (PMC-403 Biosimilar) Recombinant Monoclonal Antibody

1. Tie2-expressing pericytes limit in a paracrine manner endothelial cell sprouting angiogenesis. PMID: 28719590
2. Although several lines of evidences indicate that the Tie2 pathway might have a role in asthma, the investigated variations in the TEK gene, which are associated with lower Tie2 expression, did not influence the susceptibility to the disease. However, we found that the homozygote carriers of the rs581724 SNP had significantly increased risk to allergic conjunctivitis. PMID: 29667338
3. Under up-regulation of TIE2-R849W, egfl7 could be considered a potential reason for venous defects. Moreover, the wnt pathway may perform an important role as a key trigger for head multi-malformations. PMID: 29511374
4. TIE2 mutation type in VM, especially the mutation site, is important for future targeted therapies. PMID: 28818232
5. Rebastinib inhibition of angiopoietin/Tie2 signaling impairs multiple pathways in tumor progression mediated by protumoral Tie2(+) macrophages, including TMEM-dependent dissemination and angiopoietin/Tie2-dependent angiogenesis. Rebastinib is a promising therapy for achieving Tie2 inhibition in cancer patients. PMID: 28838996
6. Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 receptor engagement. PMID: 28580615
7. We demonstrate that ANGPT2 signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 receptor and partly directly via tumor cell surface integrin &1. PMID: 27353038
8. When Tie2 becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2, Angiopoietin-1 and Angiopoietin-2, regulate its activation status. PMID: 28582314
9. Ang-2 and sTie-2 plasma levels are increased in pediatric OSA and obesity, particularly when endothelial dysfunction or insulin resistance is detectable. PMID: 28474375
10. IL-6 and TIE2 polymorphisms are associated with baseline peritoneal transport property. PMID: 27798027
11. Results show that TIE2 phosphorylates caveolin-1 at Tyr14, and associates with caveolin-1 in caveolae. Also, its nuclear translocation is caveolin-1 dependent. PMID: 28760776
12. These results indicate that the Angpt-Tie2 system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma. PMID: 28920924
13. TEK mutations have a role in primary congenital glaucoma with variable expressivity PMID: 27270174
14. Tie1 directly interacts with Tie2 to promote ANG-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 cleavage contributes to loss of ANG2 agonist activity and vascular stability PMID: 27548530
15. ANG-1, ANG-2 and TIE-2 levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception. PMID: 28238760
16. Our data suggest that interaction of TEK and CYP1B1 contributes to primary congenital glaucoma pathogenesis and argue that TEK-CYP1B1 may perform overlapping as well as distinct functions in manifesting the disease etiology. PMID: 28620713
17. High Tie-2 expression is associated with Primary Myelofibrosis. PMID: 27281335
18. In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer. PMID: 28720059
19. Data show that fibulin-5 strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 receptor axis. PMID: 27304216
20. serum levels elevated in morbid obesity, decreased after sleeve gastrectomy PMID: 27581034
21. Blue rubber bleb nevus syndrome cased by somatic mutation of TEK. PMID: 27519652
22. Ang,Tie1 and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review] PMID: 27941161
23. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand Ang-1, but not the receptor binding domain of Ang-2, can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK signaling in the presence of both Ang-1 and fibronectin PMID: 27695111
24. Activation of Tie2 by subcutaneous injections of AKB-9778 combined with suppression of vascular endothelial growth factor (VEGF) causes a significantly greater reduction in Diabetic macular edema than that seen with suppression of VEGF alone. PMID: 27236272
25. We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 and -2 and their binding receptor Tie2 may play a role in the angiogenesis associated with the development of these lesions. PMID: 26695562
26. Calcium/calmodulin-dependent negative regulation of Tie2 can be used as an inhibitory signal for vessel growth and branching to build proper vessel architecture during embryonic development. PMID: 27199448
27. Tie2 in combination with Ca125 provides superior information to clinicians on progressive disease in patients with VEGFi-treated ovarian cancers PMID: 27351218
28. Hydroxysafflor yellow A promotes angiogenesis in HUVEC cells via the angiopoietin 1/ Tie-2 signaling pathway. PMID: 27894114
29. These results suggest that COMP-Ang1 enhances survival and proliferation of human PLFs through the activation of Tie2-mediated signaling, where PI3K/Akt and MAPK-c-Jun signaling pathways act as downstream effectors. PMID: 27107990
30. Exercise therapy increased levels of proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease. PMID: 26830098
31. These results suggested that IL-35 restrains rheumatoid arthritis angiogenesis and inflammation by downregulating basal and VEGF-induced Ang2 secretion as well as disrupting Ang2/Tie2 signal transduction. PMID: 27960151
32. High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion. PMID: 27111031
33. GTPCH/Ang-1 interaction in stromal fibroblasts and activation of Tie2 on breast tumor cells could play an important role in supporting breast cancer growth. PMID: 26814432
34. High Tie-2 expression is associated with stemness and metastatic properties of prostate cancer. PMID: 25978029
35. pro-angiogenic Tie-2-expressing monocytes (TEM) and endothelial progenitor cells (EPC) play a crucial role in Critical limb ischemia. PMID: 26462497
36. dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in hemolytic uremic syndrome PMID: 26858516
37. we report the analysis of a comprehensive collection of 22 TIE2 mutations identified in patients with vascular morphogenesis PMID: 26319232
38. The inhibition of Tie-2 exerted by Tie-1can be relieved by Tie-1 ectodomain cleavage mediated by tumor- and inflammatory-related factors, which causes destabilization of vessels and initiates vessel remodeling in cancer. (Review) PMID: 26489611
39. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1. PMID: 26659448
40. we show that VEGFA signaling from TIE2(hi) TMEM macrophages results in local, transient vascular permeability and tumor cell intravasation. PMID: 26269515
41. In the absence of Tie-2, VE-PTP inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin-supportive effect of VE-PTP. PMID: 26642851
42. Data indicate that foretinib suppresses angiogenesis and lymphangiogenesis by blocking vascular endothelial growth factor receptors PMID: 25909285
43. This study provided strong evidence supporting the disorganized vascular structures and dysregulation of related molecules in sporadic VMs. PMID: 24966004
44. Genetic variation contributes to the interindividual variation in growth factor levels and explains a modest proportion of circulating hepatocyte growth factor, Ang-2, and Tie-2. PMID: 25552591
45. Data indicate that vascular malformations (VMs) are mediated by mutations in receptor tyrosine kinase Tie2 (TEK). PMID: 26115772
46. Rapamycin improves TIE2-mutated venous malformation PMID: 26258417
47. TIE-2 levels were changed at the organ level in lethal sepsis. PMID: 24976393
48. Tie-2 expression in colorectal cancer is much higher and valuable for assessing the prognosis. PMID: 25374184
49. The data show that angiopoietin 1 and Tie2 concentrations identify a subgroup of patients who benefit from bevacizumab PMID: 24947924
50. the positive correlation between Ang-2 and Tie-2 levels in metastatic subjects, implies that cases with a Tie-2 level above the upper limits, together with higher level of Ang-2 seem to be highly predictive of metastases. PMID: 22408401

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HGNC: 11724

OMIM: 600195

KEGG: hsa:7010

STRING: 9606.ENSP00000369375

UniGene: Hs.89640