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TNFSF (Sofusa anti-TNF Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA548208MB1HU
Size US$9799
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Product Details

Uniprot No.
#N A
Target Names
TNFSF
Alternative Names
Tumour necrosis factor receptor antagonist(Sorrento Therapeutics) research-grade biosimilar
Species Reactivity
Human
Immunogen
Recombinant Human TNFSF protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant biologic is a research-grade biosimilar of the Sofusa anti-TNF program, targeting TNF-α (TNFSF2)—a master pro-inflammatory cytokine that signals through TNFR1 and TNFR2 to drive NF-κB–linked transcriptional programs and, depending on context, cell death pathways. TNF is produced by multiple immune cell types and sits upstream of broad inflammatory cascades, making TNF blockade a foundational approach for interrogating immune-mediated inflammation in models of rheumatoid arthritis and related autoimmune pathology.

The Sofusa platform has reported lymphatic delivery of etanercept (Enbrel®)—a TNFR2-Fc fusion protein designed to bind TNF and prevent its interaction with cell-surface TNF receptors—aiming to enrich drug exposure in lymphatic compartments relevant to immune activation. This biosimilar provides the TNF-binding reagent component alone, enabling researchers to study TNF biology, TNFR1/TNFR2-biased downstream responses, and assay readouts of TNF neutralization independent of device-based delivery variables. It supports mechanistic and translational workflows such as cytokine-driven signaling suppression, immune-cell activation profiling, and comparative benchmarking of TNF blockade in controlled experimental systems.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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[email protected]
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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