spa (Omodenbamab Biosimilar) Recombinant Monoclonal Antibody

Code CSB-RA336462MA1FKZ
Size US$199
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Product Details

Uniprot No.
Target Names
SpA
Alternative Names
Immunoglobulin G-binding protein A antibody; IgG-binding protein A antibody; Staphylococcal protein A (SpA) antibody; spa antibody; Omodenbamab
Species Reactivity
Staphylococcus aureus
Immunogen
Recombinant Staphylococcus aureus SpA protein
Immunogen Species
Staphylococcus aureus
Conjugate
Non-conjugated
Clonality
Monoclonal
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, FACS
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
Recommended Service
High throughput recombinant antibody production to help select the right therapeutic antibodies at competitive prices.

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Target Background

Function
Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a proinflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A.
Subcellular Location
Secreted, cell wall; Peptidoglycan-anchor.
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