ANO9 Antibody

Code CSB-PA009384
Size US$100
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Product Details

Uniprot No.
Target Names
ANO9
Alternative Names
Ano9 antibody; ANO9_HUMAN antibody; Anoctamin-9 antibody; p53-induced gene 5 protein antibody; PIG5 antibody; TMEM16J antibody; TP53I5 antibody; Transmembrane protein 16J antibody; Tumor protein p53-inducible protein 5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Anoctamin-9.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Gene References into Functions
  1. ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function. PMID: 29604966
  2. Our results showed that ANO9 is overexpressed in most pancreatic cancer cell lines tested and in B30% of tissue samples obtained from patients with pancreatic cancer. Moreover, high ANO9 expression was associated with increased proliferation of pancreatic cancer cells and poor survival in patients with pancreatic cancer. PMID: 29024940
  3. Suggest role for up-regulation of ANO9 in progression and metastasis of stage II and III colorectal carcinoma. PMID: 26317553
  4. Children with low 25-hydroxyvitamin D and TMEM16J rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death. PMID: 26872154
  5. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts. PMID: 22223854
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Protein Families
Anoctamin family
Database Links

HGNC: 20679

KEGG: hsa:338440

STRING: 9606.ENSP00000332788

UniGene: Hs.501622

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