CXXC5 Antibody

1. show here that CXXC5 is an E2-ERalpha responsive gene regulated by the interaction of E2-ERalpha with an ERE present at a region upstream of the initial translation codon of the gene PMID: 27886276
2. High CXXC5 expression seems to affect several steps in human leukemogenesis, including intracellular events as well as extracellular communication. PMID: 25605239
3. Findings suggest that overexpression of CXXC5 in C2C12 myoblasts facilitated myocyte differentiation, while RNAi interference of CXXC5 significantly inhibited the differentiation of C2C12 myoblasts. PMID: 25433557
4. Low CXXC5 expression is associated with acute myeloid leukemia. PMID: 25805812
5. targeting of CXXC5/RINF should be considered as a possible therapeutic strategy, especially in high-risk patients who show increased expression in AML cells compared with normal hematopoietic cells PMID: 23988457
6. Lack of promoter hypermethylation or somatic mutations are found in the potential tumor suppressor CXXC5 in myelodysplastic syndromes or acute myeloid leukemia with deletion 5q. PMID: 23190153
7. RINF overexpression represents an independent molecular marker for poor prognosis in breast tumors. PMID: 21325450
8. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors. PMID: 19182210
9. These findings suggest that CF5 plays a crucial role in ATM-p53 signaling in response to DNA damage. PMID: 19557330

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HGNC: 26943

OMIM: 612752

KEGG: hsa:51523

STRING: 9606.ENSP00000302543

UniGene: Hs.189119