DCBLD2 Antibody

1. Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2. PMID: 29025973
2. DCBLD2 protein expression profiles were compared between 11 invasive and non-invasive myxofibrosarcomas. Higher DCBLD2 expression was significantly associated with invasive properties of tumor cells. The expression level of DCBLD2 was consistent in different portions of tumor tissues. PMID: 28668639
3. phosphorylation of DCBLD2 Y750 recruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of AKT, thereby enhancing EGFR-driven tumorigenesis PMID: 25061874
4. ESDN associates with VEGFR-2 and regulates its complex formation with negative regulators of VEGF signaling, protein tyrosine phosphatases PTP1B and TC-PTP, and VE-cadherin. PMID: 24177422
5. SFK activity was shown to be sufficient, but not required for the interaction between ESDN and the CrkL-SH2 domain PMID: 23770091
6. ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a. PMID: 23036739
7. These findings suggest that DCBLD2 could be a potential marker and drug target for treatment of nasal polyposis in Korean asthma patients. PMID: 22261696
8. Seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD. PMID: 22468095
9. The full-length signal peptides of DCBLD2 is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
10. our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516
11. ESDN expression was significantly higher in proliferating, as compared to growth-arrested cells. ESDN overexpression in VSMC led to a decline in growth curves, while ESDN knock down had the opposite effect. PMID: 17697260
12. These data suggest that down-regulation of DCBLD2, often associated with promoter hypermethylation, is a frequent event that may be related to the development of gastric cancer. PMID: 18314483
13. ESDN modulates PDGF signaling in VSMCs via regulation of PDGFR beta surface levels. PMID: 19696027

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HGNC: 24627

OMIM: 608698

KEGG: hsa:131566

STRING: 9606.ENSP00000321573

UniGene: Hs.203691