FMO1 Antibody

1. Report developmental regulation of hepatic FMO1 expression. PMID: 26839369
2. Study tested the genetic effects of three FMOs genes (FMO1, FMO3, and FMO6P) on nicotine dependence by performing targeted sequencing on 2,852 nicotine-dependent and nondependent smokers; identified significant association signals for gene FMO1 and FMO6P PMID: 28413702
3. data support the role of FMO3 in the N-oxidation of OLA and implicate for the first time the contribution of FMO1 and its functional *6 variant in OLA disposition PMID: 23147717
4. polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology. PMID: 21540762
5. The results of this study suggested that the alteration of FMO gene expression is a consequence of the pathological environment linked to oxidative stress related to mutated SOD1. PMID: 21082301
6. FMO1 expression is restricted to the fetus; FMO1 suppression occurred within 3 d postpartum in a process tightly coupled to birth, but not gestational age. PMID: 11809920
7. data from transient expression assays in HepG2 cells suggested this SNP could account for a 2- to 3-fold loss of FMO1 promoter activity. PMID: 12829732
8. ...in fetal liver, where FMO1 predominates attaining expression levels of (about) 32% of expressed CYP3A4. p. 574 "...recent examples indicate that FMOs play a prominent role in the metabolism ...of important drugs." p. 575 PMID: 15203093
9. FMO1 was found to be down-regulated in human adult brain tissue. PMID: 16183778
10. Early studies described in this review document that FMO1 is the most abundant FMO enzyme in the human fetal liver, whereas FMO3 is essentially absent. PMID: 16863467
11. Specific allelic variants of the FMO1 gene might be associated to susceptibility to develop ALS. PMID: 17127561
12. The resulting data showed that N,N-dimethylamphetamine N-oxidation is mainly mediated by FMO1. PMID: 19552509

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HGNC: 3769

OMIM: 136130

KEGG: hsa:2326

STRING: 9606.ENSP00000346901

UniGene: Hs.1424