KLF8 Antibody

1. High KLF8 expression is associated with breast cancer cell invasion, transendothelial migration and metastasis. PMID: 26993780
2. expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8; additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes PMID: 28842254
3. Overexpression of KLF8 may contribute to the progression of pancreatic cancer, and downregulation of KLF8 expression by lentivirus-delivered shRNA is a novel therapeutic approach for PC. PMID: 26995652
4. KLF8 plays a crucial role in proliferation and migration of bladder cancer cells PMID: 25323066
5. KLF8-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis. PMID: 26320172
6. KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy PMID: 26025929
7. KLF8 suppression induced cell differentiation and inhibited tumorigenesis in colorectal cancer PMID: 26133391
8. MiR-135a inhibits migration and invasion and regulates epithelial-mesenchymal transition-related marker genes by targeting KLF8 in lung cancer cells. PMID: 26235874
9. KLF8 is a novel epithelial to mesenchymal transition regulating transcription factor that involved in the progression of gastric cancer. PMID: 25333643
10. In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation PMID: 25652467
11. A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast cancer invasion and metastasis. PMID: 24096480
12. KLF8 is involved in hypoxia-induced multidrug resistance through inhibiting apoptosis and increasing the drug release rate by directly regulating MDR1 transcription. PMID: 25040744
13. Positive nuclear KLF8 might be correlated with lower survival in gastric adenocarcinoma patients and might be an oncogene property in gastric adenocarcinoma carcinogenesis. PMID: 24461703
14. KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells. PMID: 24604387
15. KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. PMID: 23812425
16. Hypoxia-reoxygenation reduces the expression and nuclear localization of KLF8 to inhibit the trophoblast invasion by downregulating MMP-9 levels. PMID: 23703536
17. KLF8 overexpression is an important factor in human ovarian carcinoma pathogenesis. PMID: 23222713
18. KLF8 is closely associated with gastric tumor progression, angiogenesis and poor prognosis PMID: 23885141
19. High KLF8 methylation was associated with biochemical recurrence in prostate cancer. PMID: 23918943
20. With pull down assay and co-immunoprecipitation assay, the study demonstrated that KLF8 bound directly to AR, and KLF8 enhanced AR target gene transcription in human prostate cancer cells. PMID: 23023312
21. Data show that TGF-beta1 regulates E-cadherin and vimentin expression through KLF8 pathway. PMID: 23504025
22. a novel role and mechanism for KLF8 in the regulation of DNA repair and therapeutic resistance in breast cancer cells. PMID: 23105099
23. KLF8 is necessary for cell survival and invasion in gastric cancer cells. PMID: 22766838
24. Knockdown of beta-catenin by shRNA rescues the enhanced HepG2 and Hep3B cells proliferation ability induced by overexpression of KLF8 PMID: 22761862
25. Kruppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. PMID: 22276196
26. PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions. PMID: 21518760
27. Immunohistochemical staining strongly correlated the co-expression of KLF8 and MMP9 with the patient tumor invasion, metastasis and poor survival PMID: 21151179
28. KLF8 promotes hepatocellular carcinoma cell proliferation and invasion, inhibits apoptosis, and induces the epithelial-to-mesenchymal transition PMID: 20728449
29. KLF8 is possibly involved in regulating cell growth, invasion, apoptosis, and proliferation of renal carcinoma cancer; blocking this protein may be a therapeutic strategy for this cancer. PMID: 20182889
30. The gene KLF8 is abnormally expressed in a female patient with X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. PMID: 11836360
31. Over expression of KLF8 is associated with cancer PMID: 16832343
32. Functional studies using RNA interference revealed that the silencing of Sp1 and KLF8 resulted in elevated level of gamma globin expression in K562 cells. PMID: 17224162
33. Overexpression of Kruppel-like factor 8 is associated with epithelial to mesenchymal transition and epithelial cell invasion leading to breast cancer PMID: 17671186
34. FAK induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signaling pathway, leading to the activation of KLF8 promoter by Sp1 PMID: 18353772

Show More

Hide All

HGNC: 6351

OMIM: 300286

KEGG: hsa:11279

STRING: 9606.ENSP00000417303

UniGene: Hs.646614