MLLT11 Antibody

1. AF1q was up-regulated in human colorectal cancer tissues, and that this up-regulation was associated with tumor metastasis. AF1q contributes to CRC tumorigenesis through the activation of the AKT signaling pathway. PMID: 28475127
2. Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation. PMID: 27259262
3. AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression. PMID: 28423573
4. These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway. PMID: 28188793
5. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. PMID: 26079538
6. Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter. PMID: 26341630
7. AF1Q had a KFERQ-like motif. PMID: 24880125
8. AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown PMID: 22761939
9. Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors. PMID: 21715312
10. AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. PMID: 20596645
11. The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells. PMID: 15530661
12. overexpression of AF1Q leads to more progression in human breast cancer PMID: 17929166
13. The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance. PMID: 18852119
14. high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia PMID: 19396856

Show More

Hide All

HGNC: 16997

OMIM: 604684

KEGG: hsa:10962

STRING: 9606.ENSP00000357917

UniGene: Hs.75823