MTTP Antibody

Code CSB-PA015209LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA015209LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA015209LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA015209LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MTTP Polyclonal antibody
Uniprot No.
Target Names
MTTP
Alternative Names
ABL antibody; Microsomal triglyceride transfer protein (large polypeptide 88kDa) antibody; Microsomal triglyceride transfer protein 88kD antibody; Microsomal triglyceride transfer protein antibody; Microsomal triglyceride transfer protein large subunit antibody; MTP antibody; MTP large subunit antibody; MTP_HUMAN antibody; MTTP antibody; Transfer RNA, mitochondrial, proline antibody; tRNA-Pro, mitochondrial antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Microsomal triglyceride transfer protein large subunit protein (19-151AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MTTP Antibody (Product code: CSB-PA015209LA01HU) is Non-conjugated. For MTTP Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA015209LB01HU MTTP Antibody, HRP conjugated ELISA
FITC CSB-PA015209LC01HU MTTP Antibody, FITC conjugated
Biotin CSB-PA015209LD01HU MTTP Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins.
Gene References into Functions
  1. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
  2. Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease. PMID: 28950858
  3. The authors conclude that alternate splicing plays a key role in regulating cellular MTP levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP activity. PMID: 27256115
  4. these data reveal clear cellular defects in induced pluripotent stem cells-derived hepatocytes and cardiomyocytes lacking MTTP activity, including a cardiomyocyte-specific regulated stress response to elevated lipids. PMID: 28514664
  5. two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL) patients, are reported. PMID: 27487388
  6. results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD PMID: 28953935
  7. Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB but not of truncated APOB. (APOB = apolipoprotein B; MTTP = microsomal triglyceride transfer protein) PMID: 28702990
  8. In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes. PMID: 28356060
  9. High expression of MTTP is associated with high carotid intima-media thickness. PMID: 27841945
  10. Its gene mutations are associated with abetalipoproteinemia, developmental delay and hepatic steatosis. PMID: 27160094
  11. MTP Gene Variants are associated with Homozygous Familial Hypercholesterolemia. PMID: 27170061
  12. the N-terminal domain of MTP is important for its lipid transfer activity PMID: 26224785
  13. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression. PMID: 25921304
  14. Results present evidence that MTTP polymorphisms could modulate the lipid homeostasis to determine the serum lipids and increase risk of non-alcoholic fatty liver disease. PMID: 26458397
  15. Findings from meta-analysis indicate that the MTP -493G/T polymorphism may contribute to the development of non-alcoholic fatty liver disease. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of the disease. PMID: 25501226
  16. Homozygous MTTP mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia. PMID: 24842304
  17. MTTP SNPs (GG, GT, TT) and alleles (G, T) in the chronic hepatitis C (genotype 4) patients versus the uninfected controls were 70%, 21%, 9% & 80.5%, 19.5% versus 10%, 87.5%, 2.5% & 53.8%, 46.3%, respectively (p=0.0001). PMID: 25287167
  18. The MTP-493G/T polymorphism modulates postprandial apoB48 and apoB100 of triglyceride-rich lipoproteins in familial combined hyperlipidemia PMID: 24378322
  19. Case Reports: novel mutation in MTTP gene responsible for abetalipoproteinemia in Tunisian families. PMID: 23556456
  20. Report of two new mutations of MTTP, a nonsense mutation c.2313T > A leading to a truncated protein (p.Y771X) and a splice mutation IVS 9 + 2T > G, in abetalipoproteinemia PMID: 24139731
  21. MTTP genetic polymorphisms influence the susceptibility to developing NAFLD in the Han Chinese population. PMID: 23738963
  22. Meta-analysis results revealed that MTP -493G>T polymorphism was strongly correlated with an increased risk of nonalcoholic fatty liver disease. [Meta-analysis] PMID: 24588800
  23. The MTTP rs1800591 T allele could be a risk factor for metabolic syndrome in patients under atypical antipsychotic medication PMID: 23609384
  24. ABL is associated with the absence of both triglyceride and phospholipid transfer activities in MTP. PMID: 23475612
  25. MTP inhibition increased transcription of the GPT/GOT1 genes through up-regulation of the IRE1alpha/cJun pathway leading to increased synthesis and release of ALT1/AST1 PMID: 23532846
  26. MTP -493G/T polymorphism may play an important role in fashioning the serum lipid profiles of Bama populations, despite no direct association between MTP -493G/T and longevity was detected. PMID: 23273182
  27. An interaction between MTTP -164T > C functional polymorphism with total cholesterol levels and risk of cardiovascular disease. PMID: 23356586
  28. The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients PMID: 22147193
  29. MTTP mutations found in Tunisian children with chylomicron retention disease and abetalipoproteinemia were shown to disrupt mRNA splicing leading to premature termination codons . PMID: 23043934
  30. MTTP gene genotype is significantly overrepresented in centenarians and their offspring. PMID: 22496539
  31. two new mutations in MTTP in patients with abetalipoproteinemia PMID: 22150066
  32. a novel mechanism of MTP repression that involves binding of NR2F1 to the DR1 element and recruitment of corepressors PMID: 22357705
  33. nonalcoholic steatohepatitis(NASH)patients had higher incidence of MTP G/G genotype compared to controls; NASH patients also had a 100% prevalence of MnSOD T/T genotype; certain genotypes in MTP and MnSOD are more prevalent among obese children with NASH PMID: 21727734
  34. two mutations lead to abnormal truncated MTTP proteins, incapable of binding protein disulfide isomerase and responsible for the loss of function of MTTP in two children with a severe form of abetalipoproteinemia. PMID: 21394827
  35. the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in nonalcoholic fatty liver disease PMID: 21438662
  36. The MTP gene analysis by direct sequencing revealed a novel homozygous mutation (c.1586 A > G-H529R) in abetalipoproteinemia PMID: 21502686
  37. these results suggest that changes in MTP protein expression are not responsible for insulin-mediated suppression of apo B-containing lipoprotein secretion by the liver. PMID: 21316344
  38. we report here for the first time that MTP-493G/T polymorphism is associated with pancreatic beta-cell dysfunction, as assessed by two independent and validated methods, in NASH and healthy controls. PMID: 19733470
  39. MTP deficiency was associated with increased proteasomal degradation of group 1 CD1 molecules in human abetalipoproteinemia. PMID: 20592474
  40. MTTP-I128T polymorphism is associated with central obesity, elevated liver enzymes, and alcoholic fatty liver disease. PMID: 19262398
  41. Polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes may be associated with non-alcoholic liver disease progression. PMID: 19817962
  42. Transcriptional and posttranscriptional mechanisms involving NR2F1 and IRE1beta ensure low microsomal triglyceride transfer protein expression in undifferentiated intestinal cells and avoid apolipoprotein B lipoprotein biosynthesis. PMID: 20007910
  43. carriers of the minor -164C allele have lower expression of MTTP in the heart, mediated at least partly by the transcription factor CCAAT/enhancer binding protein. Reduced concentration of MTTP in the myocardium may contribute to ischemic heart disease PMID: 19546343
  44. MTP can function in both rough and smooth regions of endoplasmic reticulum in human hepatoma cells. PMID: 12020640
  45. Increased MTP gene expression and apoB mRNA levels are found in ventricular myocytes of patients undergoing coronary artery bypass surgery. PMID: 12231571
  46. insulin inhibits MTP gene transcription through MAPK(erk) cascade but not through the PI 3-kinase pathway PMID: 12716735
  47. MTP genotye -493G/T polymorphism only has a minor effect on LDL cholesterol subfraction pattern in chinese patient. PMID: 12818411
  48. genetic association study identified a haplotype marker within microsomal transfer protein as a modifier of human lifespan PMID: 14615589
  49. Microsomal triglyceride transfer protein (MTP) has been associated with ABL. PMID: 14741197
  50. functional polymorphisms in MTP and MnSOD may be involved in determining susceptibility of non-alcoholic steatohepatitis PMID: 15094225

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Involvement in disease
Abetalipoproteinemia (ABL)
Subcellular Location
Endoplasmic reticulum. Golgi apparatus.
Tissue Specificity
Liver and small intestine. Also found in ovary, testis and kidney.
Database Links

HGNC: 7467

OMIM: 157147

KEGG: hsa:4547

STRING: 9606.ENSP00000265517

UniGene: Hs.195799

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