MXD4 Antibody

Code CSB-PA257244
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MAD4 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MXD4 Polyclonal antibody
Uniprot No.
Target Names
MXD4
Alternative Names
bHLHc12 antibody; Class C basic helix loop helix protein 12 antibody; Class C basic helix-loop-helix protein 12 antibody; MAD 4 antibody; MAD4 antibody; Mad4 homolog antibody; MAD4_HUMAN antibody; Max associated protein 4 antibody; MAX dimerization protein 4 antibody; Max dimerizer 4 antibody; Max interacting transcriptional repressor MAD4 antibody; Max-associated protein 4 antibody; Max-interacting transcriptional repressor MAD4 antibody; MST 149 antibody; MST149 antibody; MSTP 149 antibody; MSTP149 antibody; MXD 4 antibody; MXD4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human MAD4.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Gene References into Functions
  1. The E3 ligase activity of c-IAP1 was not required for downregulation of Mad4 expression. PMID: 22895069
  2. regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc PMID: 12418961
  3. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
  4. replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes PMID: 16167342
Subcellular Location
Nucleus.
Database Links

HGNC: 13906

KEGG: hsa:10608

STRING: 9606.ENSP00000337889

UniGene: Hs.655020

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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