NCAPH Antibody

Datasheet

Code	CSB-PA621857DSR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA621857DSR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NCAPH Polyclonal antibody

Uniprot No.

Q15003

Target Names

NCAPH

Alternative Names

Barren Drosophila Homolog of 1 antibody; Barren homolog protein 1 antibody; BRRN antibody; BRRN1 antibody; CAP H antibody; CAPH antibody; Chromosome associated protein H antibody; Chromosome-associated protein H antibody; CND2_HUMAN antibody; Condensin complex subunit 2 antibody; Condensin subunit 2 antibody; Condensin-2 complex subunit H2 antibody; Condesin antibody; HCAP H antibody; hCAP-H antibody; KIAA0074 antibody; mCAP H antibody; MGC4616 antibody; Ncaph antibody; Non SMC condensin I complex subunit H antibody; Non-SMC condensin I complex subunit H antibody; XCAP H homolog antibody; XCAP-H homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Condensin complex subunit 2 protein (1-250AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

Gene References into Functions

NCAPH high expression promotes colonic cancerous cell proliferation. PMID: 28300828
Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death. PMID: 21151026
Our results identify a SSB-specific response of condensin I through PARP-1 and demonstrate a role for condensin in SSB. repair. PMID: 16543152

Subcellular Location

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Protein Families

CND2 (condensin subunit 2) family

Tissue Specificity

Widely expressed at low level. Expressed in proliferating cells.

Database Links

HGNC: 1112

OMIM: 602332

KEGG: hsa:23397

STRING: 9606.ENSP00000240423

UniGene: Hs.308045

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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