PIWIL2 Antibody

1. n vitro experiments demonstrated a possible role of the PIWIL2/HILI short isoform in repressing TEs, which could provide a growth advantage for testicular germ cell tumors through securing their genome integrity. PMID: 29301509
2. A statistically significantly higher level of PIWIL1 and PIWIL2 was found in IDC compared to mastopathy samples (pPMID: 29599319
3. this study shows that an unusual intragenic promoter of PIWIL2 contributes to aberrant activation of oncogenic PL2L60 PMID: 28545024
4. High expression of PIWIL2 is associated with glioma. PMID: 28534979
5. Protein expression levels of PIWIL2 was significantly up-regulated in both papillary and micropapillary thyroid cancers (p<0.01). Moreover, consistent with protein expression levels, mRNA expression levels of PIWIL2 was elevated in both papillary and micropapillary thyroid cancer tissues. PMID: 29369786
6. Results revealed that Piwil2 exhibits 100% positive expression in the cell nucleus, with the intensity higher than in the cytoplasm. Along with nuclear location of PIWIL4, PIWIL2 expression is associated with worse prognosis of hepatocellular carcinoma. PMID: 27894076
7. this study demonstrates that Piwil2, reactivated by the human papillomavirus oncoproteins E6 and E7, plays an essential role in the transformation of cervical epithelial cells to tumor-initiating cells via epigenetics-based cell reprogramming PMID: 27602489
8. Data show that the PIWIL2 protein transfected fibroblast cells grew into tumorous masses within 5 weeks of subcutaneous injection into adult nude mice. PMID: 28103575
9. report demonstrated that human Piwil proteins, especially Hili, not only bind to select tRNA species, including rare tRNAs, but also inhibit HIV replication PMID: 28331090
10. PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients PMID: 27893851
11. MMP9 and PIWIL2 expression levels in cancerous tissues were significantly higher than the adjacent normal tissues PMID: 27215085
12. PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression PMID: 26373553
13. Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients PMID: 25998509
14. Univariate analysis demonstrated that high PIWIL2 expression was associated with shorter survival time after radical resection. PMID: 26125915
15. Knockdown of Piwil2 gene in SiHa cells inhibited cell growth and invasion, and downregulated matrix metalloproteinase-9 (MMP-9) compared to scrambled shRNA transfected cells PMID: 26775345
16. Results show that both PIWIL2 protein isoforms are expressed in testicular germ cell lines but in the tumors, the short protein and mRNA are predominant and highly expressed in undifferentiated tumors. PMID: 25384072
17. Our results indicate a reciprocal regulation between HIWI, HILI and some CSCs markers in colorectal cancer PMID: 26026091
18. PIWIL2 modulates tumor cell proliferation and F-actin filaments by interacting with NME2 and regulating c-Myc expression. PMID: 25193865
19. This study revealed critical negative regulation of TGF-beta signalling by PIWIL2 in HepG2 tumour cells. PMID: 25040173
20. Study indicates that Piwil2 plays a role in Fas-mediated apoptosis and can affect p53 phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 in apoptosis, and supports that Piwil2 plays an active role in tumorigenesis. PMID: 25113562
21. High Piwil2 expression is associated with breast cancer. PMID: 23992744
22. Our study identifies surrogate DNA methylation markers for idiopathic infertility in peripheral blood and suggests that allele-specific DNA methylation differences at regulatory sites of genes are associated with disturbed spermatogenesis. PMID: 24524831
23. Data suggest that the epitopes could be used as novel candidates to the immunotherapy of HLA-A2 positive patients with tumors expressing PL2L60, the spliced fragment of PIWIL2. PMID: 24077852
24. DNA methylation, at least that affecting PIWIL2/TDRD1, has a role in the control of gene expression in spermatogenesis and its imbalance contributes to an unsuccessful germ cell development that might explain a group of male infertility disorders. PMID: 23112866
25. Piwil2 moderates the proliferation and metastasis potential of colon cancer. PMID: 23104504
26. we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. PMID: 22748119
27. a critical negative regulation level of TGF-beta signaling mediated by HILI (human PIWIL2) by its ability to interact with Hsp90 and promote TbetaR degradation PMID: 22848678
28. Piwil2 plays a role in anti-apoptosis in tumor cells possessing P53 as a positive regulator of STAT3 signaling pathway. PMID: 22303479
29. a new role for Piwil2 in DNA repair PMID: 22110608
30. Piwil2 may play a role in the invasion and metastasis of papillary thyroid carcinoma. PMID: 21575418
31. The study demonstrated that HILI along with piRNAs plays a role in LINE1 suppression in Hela cancer cell line. PMID: 20846497
32. piwil2 is expressed in various stages of breast cancers and has the potential to be used a novel biomarker. PMID: 20490325
33. Findings define Piwil2 and its effector signaling pathways as key factors in the proliferation and survival of breast cancer stem cells. PMID: 20460541
34. our study indicates that PIWIL2 does not play a role in carcinogenesis of human bladder carcinoma PMID: 19683485
35. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. PMID: 16377660

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HGNC: 17644

OMIM: 610312

KEGG: hsa:55124

STRING: 9606.ENSP00000349208

UniGene: Hs.614809