PRDM16 Antibody

1. Study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of lung adenocarcinoma. PMID: 30132554
2. Multiple regression analysis showed that age, male gender, body max index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and left ventricular ejection fraction were associated with the expression levels of UCP1, PGC1alpha and PRDM16 mRNA PMID: 28824327
3. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
4. High PRDM16 expression is a significant predictive marker for poor prognosis in adult AML patients. PMID: 28710806
5. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
6. Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer. PMID: 27511603
7. A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients PMID: 26502740
8. High PRDM16 expression is associated with astrocytoma. PMID: 26701852
9. Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia. PMID: 26559765
10. Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML and is associated with adverse outcome PMID: 26684393
11. PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis. PMID: 25662275
12. EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia PMID: 25567132
13. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 locus) were associated with QRS duration; and rs17026156 (SLC8A1 locus) correlated with PR interval. PMID: 25035420
14. Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass. PMID: 24863034
15. MED1 is required for optimal PRDM16-induced Ucp1 expression PMID: 25644605
16. PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells. PMID: 24966940
17. Mutations in gene encoding the transcriptional co-activator PRDM16 may be a cause of left-ventricular noncompaction and dilated cardiomyopathy. PMID: 24717670
18. The rs2651899 variant in PRDM16 plays a role in Chinese common migraine susceptibility. PMID: 24021092
19. An association between PRDM16 rs2651899 SNP and migraine in a Swedish case-control study. PMID: 24674449
20. No association between the four polymorphisms of the PRDM16 gene with essential hypertension. PMID: 24327154
21. Single nucleotide polymorphism Rs2236518 is associated with body mass index in the young Chinese males (using QTDT), and the older Chinese males (using GLM-ANOVA). PMID: 23524569
22. Mutation of PRDM16 causes the cardiomyopathy in 1p36 deletion syndrome as well as a proportion of nonsyndromic left ventricular noncompaction cardiomyopathy and dilated cardiomyopathy. PMID: 23768516
23. High PRDM16 expression is associated with pheochromocytoma. PMID: 23454374
24. Data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin. PMID: 22939622
25. genetic association studies in a Chinese Xinjiang Uygur population: Studies suggest that commonly occurring SNP in PRDM16 (rs2236518) shows a significant negative association with metabolic syndrome in a multivariable logistic regression analysis. PMID: 22383139
26. Survival data suggest that patients with AML/MDS and PRDM16 translocations have a poor prognosis despite a simple karyotype and a median age of 65 years. PMID: 22050763
27. genome-wide association studies have successfully identified four new genetic variants associated with migraine in the LRP1, TRPM8, and PRDM16 genes PMID: 22072275
28. Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus PMID: 22039459
29. Breakpoints occurring in the first intron and in the 5' region of the MEL1 gene associated with the t(1;3)(p36;q21) translocation have been found in three myelodysplastic syndrome/acute myelogenous leukemia patients. PMID: 12557231
30. structure, expression pattern, and function of MEL1 in leukemia cells; overexpression of the zinc finger protein lacking the PR domain (EVI1 and MEL1S)is likely one of the causative factors in the pathogenesis of myeloid leukemia. PMID: 12816872
31. Aberrant gene expression associated with DNA hypomethylation is implicated in leukemogenesis of adult T-cell leukemia. PMID: 14656887
32. Correction opf X-linked chronic granulomatous disease by gene therapy was augmented by insertional activation of PRDM16. PMID: 16582916
33. A 3' RACE experiments followed by sequence-specific RT-PCR resulted in the identification of the PRDM16 gene as a novel fusion partner of the RUNX1 gene in a patient with rare t(1;21)(p36;q22). PMID: 16598304
34. RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance PMID: 18202228
35. array CGH performed on CD34(+) cells revealed cryptic partial deletions of PRDM16. PMID: 18767145
36. SKI and MEL1 knockdown synergistically restored TGF-beta responsiveness in MKN28 cells and reduced tumor growth in vivo PMID: 19049980
37. PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes. PMID: 19285866
38. PRDM16 and PGC-1 alpha expression was 2-fold greater in epicardial than sc fat. PMID: 19567523
39. data indicate that the PRDM16-C/EBP-beta complex initiates brown fat formation from myoblastic precursors PMID: 19641492

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HGNC: 14000

OMIM: 605557

KEGG: hsa:63976

STRING: 9606.ENSP00000270722

UniGene: Hs.99500