PSMC3 Antibody

Datasheet

Code	CSB-PA018891LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA018891LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA018891LA01HU at dilution of 1:100 Immunofluorescence staining of A549 cells with CSB-PA018891LA01HU at 1:530, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMC3 Polyclonal antibody

Uniprot No.

P17980

Target Names

PSMC3

Alternative Names

26S protease regulatory subunit 6A antibody; 26S proteasome AAA-ATPase subunit RPT5 antibody; Human immunodeficiency virus tat transactivator binding protein 1 antibody; MGC8487 antibody; Proteasome (prosome macropain) 26S subunit ATPase 3 antibody; Proteasome 26S ATPase subunit 3 antibody; Proteasome 26S subunit ATPase 3 antibody; Proteasome subunit P50 antibody; PRS6A_HUMAN antibody; PSMC 3 antibody; PSMC3 antibody; Tat binding protein 1 antibody; TAT-binding protein 1 antibody; TBP-1 antibody; TBP1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human 26S proteasome regulatory subunit 6A protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PSMC3 Antibody (Product code: CSB-PA018891LA01HU) is Non-conjugated. For PSMC3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018891LB01HU	PSMC3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018891LC01HU	PSMC3 Antibody, FITC conjugated
Biotin	CSB-PA018891LD01HU	PSMC3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene References into Functions

These data suggest the existence of a negative feedback loop involving Akt/PKB that might act as a sensor to modulate TBP-1 levels in proliferating cells. PMID: 21991300
19S ATPase S6b (S6'/TBP1) binds CIITApIV in an S6a-dependent fashion and has effects similar to S6a on CIITApIV histone acetylation. PMID: 19853614
role in E3 ubiquitin ligase function of the von Hippel-Lindau protein PMID: 14556007
molecular modeling of DNA:TATA element binding protein (TBP) interactions after treatment with 2-Chloro-2'-deoxyadenosine PMID: 14610662
Tat-binding protein-1 binds to human ARF tumor suppressor and has a role in control of cell proliferation PMID: 14665636
In normal cells, unmodified S12 associates with the 26S proteasome, while modified S12-M does not. PMID: 15221960
The stabilization effect exerted by TBP-1 requires an intact N-terminal 39 amino acids in ARF and occurs independently from N-terminal ubiquitination of the protein. PMID: 17334400
Heplipin induced KG-1 cell apoptosis is related with Wntl3 and ATPase3. PMID: 17649721
findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP. PMID: 19325002

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

AAA ATPase family

Database Links

HGNC: 9549

OMIM: 186852

KEGG: hsa:5702

STRING: 9606.ENSP00000298852

UniGene: Hs.250758

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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