TLR13 Antibody

Datasheet

Code	CSB-PA080183
Size	US$119
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Image	Immunohistochemical analysis of paraffin-embedded Mouse Spleen Tissue using TLR13 Polyclonal Antibody.
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Product Details
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Target Background

Product Details

Uniprot No.

Q6R5N8

Target Names

Tlr13

Alternative Names

Tlr13 antibody; Toll-like receptor 13 antibody; EC 3.2.2.6 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant Protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Form

Liquid

Tested Applications

IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-500
ELISA	1:10000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.

Gene References into Functions

Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA has been presented. PMID: 26676765
S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 and subsequently by TLR13 upon internalization. PMID: 25756897
TLR13 expressed by immune cells detects bacterial RNA with exquisite sequence specificity. PMID: 23110254
These data lend support to the conclusion that TLR13 participates in group B streptococcus recognition, although blockade of the function of this receptor can be compensated for by other endosomal toll-like receptors. PMID: 25225249
TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA. PMID: 22896636
these results show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably PMID: 22821982
the potential role of the novel Toll-like receptor tlr13 in the recognition of viral infection. PMID: 21131352
These findings reveal the mechanism of Tlr13 gene regulation, thereby providing insight into the function of Tlr13 in the immune response to pathogen. PMID: 19487701

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Subcellular Location

Endosome membrane; Single-pass type I membrane protein.

Protein Families

Toll-like receptor family

Database Links

KEGG: mmu:279572

STRING: 10090.ENSMUSP00000043101

UniGene: Mm.336203

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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