TNRC6A Antibody

1. that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities PMID: 28837617
2. The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. PMID: 28488892
3. The results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Argonaute proteins. PMID: 26446993
4. TRIM65 relieves miRNA-driven suppression of mRNA expression through ubiquitination and subsequent degradation of TNRC6. PMID: 24778252
5. we have identified a new function of GW182 in protecting mature miRNA from being degraded by interacting with Argonaute (AGO) proteins PMID: 23090477
6. HSP90 and GW182 are important factors in the pathomechanism of alcohol-induced augmentation of HCV replication. PMID: 22898980
7. GW182 plays a critical role in miRNA-mediated gene silencing. (Review) PMID: 23224966
8. GW182 proteins function as scaffold proteins for the assembly of the multiprotein complex that silences miRNA targets. (Review) PMID: 23224969
9. 28.6% of patients containing autoantibodies to the trinucleotide repeat region of the TNRC6A were shown to have a single nucleotide polymorphism at c.344C>A in the CAG/CCA/G-rich region of TNRC6A. PMID: 23224974
10. Sinse Argonaute and GW182 are the core proteins of the RNA-silencing complex (RISC), it seems appropriate to suggest that the RISC is the main target of human autoantibodies. (Review) PMID: 23224975
11. Analysis of the results suggested that TNRC6A plays an important role in navigating Argonaute protein into the nucleus to lead miRNA-mediated gene silencing. PMID: 23150874
12. Mammalian GW proteins have distinctive functions in the miRNA pathway, with GW220/TNGW1 being essential for aggregation and formation of GW/P bodies that sequester and stabilize translationally repressed target mRNA. PMID: 22891262
13. Data demonstrate that in human and Drosophila melanogaster cells, the critical repressive features of both the N-terminal and C-terminal effector domains of GW182 proteins are Gly/Ser/Thr-Trp (G/S/TW) or Trp-Gly/Ser/Thr (WG/S/T) motifs. PMID: 21984184
14. Data suggest that GW182 serves as both a platform that recruits deadenylases and as a deadenylase coactivator that facilitates the removal of the poly(A) tail by CCR4-NOT. PMID: 21984185
15. Alanine substitution showed that GW/WG motifs in Delta12 (Delta12a, amino acids 896-1045) were important for the silencing activity of GW182. PMID: 21131274
16. GW ribonucleoprotein complex is involved in the posttranscriptional regulation of gene expression PMID: 11950943
17. gene knockdown of GW182 led to the disappearance of GW bodies demonstrating that GW182 is a critical component of GW bodies PMID: 15494374
18. data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing PMID: 16284622
19. results support a functional link between GW182 and the ability of a microRNA to repress expression of a target mRNA PMID: 16284623
20. A novel 210-kDa isoform of human GW182, provisionally named trinucleotide GW1 (TNGW1)was reported.TNGW1 was expressed independently of GW182 and was present in human testis and various human cancer cells. PMID: 19056672
21. Our findings indicate that TNRC6A, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768

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HGNC: 11969

OMIM: 610739

KEGG: hsa:27327

STRING: 9606.ENSP00000379144

UniGene: Hs.655057