ZNF366 Antibody

1. These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-kappaBp65 after TLR activation in human DCs. PMID: 26170389
2. these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells. PMID: 25663546
3. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ. PMID: 23440419
4. DC-SCRIPT is a key regulator of androgen receptor and vitamin d receptor that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer. PMID: 22473304
5. DC-SCRIPT has a primary role in the regulation of interleukin (IL)-10 production by monocytes. PMID: 22615205
6. study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors PMID: 21122099
7. DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review] PMID: 20478364
8. DC-SCRIPT consists of a proline-rich region, 11 C2H2-type zinc fingers, and an acidic region. Localization studies reveal that DC-SCRIPT resides in the nucleus and that nuclear localization is critically dependent on the zinc fingers. (DC-SCRIPT) PMID: 16393996
9. Results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen. PMID: 17085477
10. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study PMID: 19525478

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HGNC: 18316

OMIM: 610159

KEGG: hsa:167465

STRING: 9606.ENSP00000313158

UniGene: Hs.224794