ascl1a Antibody

^{Rare Species}

Datasheet

Code	CSB-PA852654LA01DIL
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) ascl1a Polyclonal antibody

Uniprot No.

Q90259

Target Names

ascl1a

Alternative Names

ascl1a antibody; ash antibody; ash1a antibody; asha antibody; piaAchaete-scute homolog 1a antibody; Zash-1a antibody; Pituitary-absent protein antibody

Raised in

Rabbit

Species Reactivity

Zebrafish

Immunogen

Recombinant Zebrafish Achaete-scute homolog 1a protein (1-196AA)

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

The ascl1a Antibody (Product code: CSB-PA852654LA01DIL) is Non-conjugated. For ascl1a Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA852654LB01DIL	ascl1a Antibody, HRP conjugated	ELISA
FITC	CSB-PA852654LC01DIL	ascl1a Antibody, FITC conjugated
Biotin	CSB-PA852654LD01DIL	ascl1a Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter. Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.

Gene References into Functions

dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification PMID: 23747543
bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine PMID: 23352790
Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility PMID: 23353550
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a. PMID: 21911394
The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. PMID: 20935637
Expressed in the postsembryonic zebrafish brain PMID: 12638130
ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh PMID: 12702659
Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3) signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis PMID: 16481349
Cellular correlates of proneural gene(ash1a) expression in the regenerating zebrafish retina. PMID: 17822581
ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia. PMID: 18234889

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Subcellular Location

Nucleus.

Tissue Specificity

In the 24 hours embryo, expressed in the dorsal hindbrain in two bilaterally symmetrical lines of cells marking the boundary between the alar and basal plates, and ventrally in rhombomere 1 near the floor plate. Also expressed in embryonic adenohypophysis

Database Links

KEGG: dre:30466

STRING: 7955.ENSDARP00000056004

UniGene: Dr.314

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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