Recombinant Human C-C motif chemokine 21 protein(CCL21) (Active)

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Code CSB-AP000941HU
Product Type Chemokine
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Uniprot No. O00585
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Storage Buffer 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl,lyophilized
Alias 6Ckine, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 10-100 ng/ml.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCK RTERSQTPKG P
Research Area Immunology
Source E.Coli
Gene Names CCL21
Expression Region 24-134aa
Tag Info Tag-Free
Mol. Weight 12.2 kDa
Protein Description Full Length of Mature Protein
PubMed ID 9235955; 9257816; 9300671; 9419363; 12975309; 15489334; 9507024; 23341447; 22221265
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Function Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart
Database Links

HGNC: 10620

OMIM: 602737

KEGG: hsa:6366

STRING: 9606.ENSP00000259607

UniGene: Hs.57907

Pathway Chemokine signaling pathway
NF-kappa B signaling pathway

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