CCL21, also known as C-C motif chemokine ligand 21, has alternative names including ECL, SLC, CKb9, TCA4, and SCYA21. CCL21 is a small molecule cytokine belonging to the CC chemokine family. It is primarily constitutively expressed at the origin of lymphatics and in lymphoid organs, present on several types of stromal cells and high endothelial villi (HEV). CCL21 can bind to glycosaminoglycans (GAGs) and fix itself to the surface of endothelial cells.
The biological functions of CCL21 are achieved through its binding to chemokine receptors CCR7 and CXCR3. CCL21 has chemotactic effects on thymocytes and activated T cells in vitro but does not chemotactically affect B cells, macrophages, or neutrophils. Additionally, CCL21 is an effective stimulator of T cell migration and adhesion, promoting the migration of T cells to secondary lymphoid organs and playing a crucial role in the homing of lymphocytes to secondary lymphoid organs, thus exerting significant immune regulatory functions.
Recombinant Human C-C motif chemokine 21 (CCL21) (CSB-EP004785HUc0)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA576836(CCL21 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA576836(CCL21 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The following CCL21 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CCL21 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA576836 | CCL21 Antibody | Human | ELISA,IHC |
CSB-PA929761 | CCL21 Antibody | Human | ELISA,IHC |
CSB-PA004785DB01HU | CCL21 Antibody, HRP conjugated | Human | ELISA |
CSB-PA004785DC01HU | CCL21 Antibody, FITC conjugated | Human | |
CSB-PA004785DD01HU | CCL21 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA004785DA01HU | CCL21 Antibody | Human | ELISA, IHC |
CCL21 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004785HU CSB-BP004785HU CSB-MP004785HU CSB-EP004785HU-B |
Recombinant Human C-C motif chemokine 21 (CCL21) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004785HU | Recombinant Human C-C motif chemokine 21 (CCL21) | E.coli |
CSB-AP000941HU | Recombinant Human C-C motif chemokine 21 protein (CCL21) | E.Coli |
CSB-EP004785HUc0 | Recombinant Human C-C motif chemokine 21 (CCL21) | E.coli |
CCL21 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP812822MOW CSB-EP812822MOW CSB-BP812822MOW CSB-MP812822MOW CSB-EP812822MOW-B |
Recombinant Macaca mulatta C-C motif chemokine 21 (CCL21) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL21 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04521h | Human secondary lymphoid-tissue chemokine,SLC ELISA Kit | serum, plasma | 19.5 pg/mL |