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| Code | CSB-PA004785DA01HU |
| Size | US$299 |
| Uniprot No. | O00585 |
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol |
| Immunogen | Recombinant Human C-C motif chemokine 21 protein (24-134AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA, IHC; Recommended dilution: IHC:1:200-1:500 |
| Relevance | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21), CCL21, SCYA21 |
| Immunogen Species | Human |
| Research Area | Immunology |
| Target Names | CCL21 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Subcellular Location | Secreted |
| Protein Families | Intercrine beta (chemokine CC) family |
| Tissue Specificity | Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart |
| Database Links |
HGNC: 10620 OMIM: 602737 KEGG: hsa:6366 STRING: 9606.ENSP00000259607 UniGene: Hs.57907 |
| Pathway |
Chemokine signaling pathway
NF-kappa B signaling pathway |
CCL21 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA576836 | CCL21 Antibody | Human | ELISA,IHC |
| CSB-PA929761 | CCL21 Antibody | Human | ELISA,IHC |
CCL21 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004785DB01HU | CCL21 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004785DC01HU | CCL21 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA004785DD01HU | CCL21 Antibody, Biotin conjugated | Human | ELISA |
CCL21 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP004785HU CSB-BP004785HU CSB-MP004785HU |
Recombinant Human C-C motif chemokine 21(CCL21) | Yeast Baculovirus Mammalian cell |
| CSB-EP004785HU | Recombinant Human C-C motif chemokine 21(CCL21) | E.coli |
| CSB-AP000941HU | Recombinant Human C-C motif chemokine 21 protein(CCL21) (Active) | E.Coli |
CCL21 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04521h | Human secondary lymphoid-tissue chemokine,SLC ELISA Kit | serum, plasma | 20 pg/mL |
