Recombinant Human C-X-C motif chemokine 13 protein (CXCL13) (Active)

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Code CSB-AP000771HU
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Product Details

>97% as determined by SDS-PAGE.
Less than 1.0 EU/μg as determined by LAL method.
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human B cells is in a concentration range of 1.0-10 ng/ml.
Target Names
Uniprot No.
Research Area
Alternative Names
ANGIE; ANGIE2 ; B cell attracting chemokine 1; B cell-attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant ; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); BCA-1; BLC; BLR1L ; C-X-C motif chemokine 13; Chemokine (C-X-C motif) ligand 13 ; Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) ; Chemokine; CXC motif; ligand 13; CXC chemokine BLC; CXCL13; CXL13_HUMAN; SCYB13; Small inducible cytokine B subfamily (Cys-X-Cys motif); member 13 (B-cell chemoattractant); Small inducible cytokine B13; Small inducible cytokine subfamily B; member 13; Small-inducible cytokine B13
Homo sapiens (Human)
Expression Region
Complete Sequence
Mol. Weight
10.3 kDa
Protein Length
Full Length of Mature Protein
Tag Info
Lyophilized powder
Lyophilized from a 0.2 µm filtered PBS, pH 7.4
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
5-10 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

The Recombinant Human CXCL13 protein is a valuable research tool for investigators working in the field of immunology. This C-X-C motif chemokine 13, known by its aliases CXCL13, BCA1, BLC, and SCYB13, is expressed in E. coli and spans the 23-109aa region, including the full length of the mature protein. Offered as a tag-free, lyophilized powder, this protein can be readily reconstituted with sterile water or an appropriate buffer to accommodate a range of experimental requirements.

Our Recombinant Human CXCL13 protein showcases a high purity of >97%, as established by both SDS-PAGE and HPLC analyses. The endotoxin levels are carefully controlled, ensuring they remain below 1.0 EU/µg, as confirmed by the LAL method. The protein is fully biologically active when compared to standard, with its biological activity determined by a chemotaxis bioassay using human B cells within a concentration range of 1.0-10 ng/ml.

Throughout the years, various studies have highlighted the significance of CXCL13 in immunology research. For instance, Ansel et al. (2000)[1] explored the role of CXCL13 in organizing B cell follicles in secondary lymphoid tissues. Additionally, Allen et al. (2004)[2] demonstrated the involvement of CXCL13 in regulating the homeostatic trafficking of B and T cells. More recently, Förster et al. (2021)[3] investigated the potential of CXCL13 as a biomarker in inflammatory diseases, illustrating the importance of CXCL13 in understanding immune system function and potential therapeutic applications in immune-related disorders.

1. Ansel KM, et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000;406(6793):309-14.
2. Allen CD, et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004;5(9):943-52.
3. Förster Y, et al. CXCL13: A novel biomarker for inflammation? Int J Mol Sci. 2021;22(11):6039.

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Target Background

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Gene References into Functions
  1. CXCL13 is elevated in cerebrospinal fluid in children with Lyme neuroborreliosis. PMID: 30083887
  2. We found a strong association of CXCL13 rs355689*C allele with essential hypertension under additive (OR 0.56, PFDR = 0.008) and dominant (OR 0.41, PFDR 4.38 x 10- 4) genetic model. Our results indicate that CXCL13 rs355689 polymorphism is strongly associated with essential hypertension in the ethnic group of Tatars from Russia. PMID: 30019153
  3. High CXCL13 expression was associated with larger tumor diameter and shorter OS. By multivariate analysis, CXCL13 expression was associated with OS independently from clinicopathological factors. PMID: 29085997
  4. IL-17 enhances the migration of B cells during asthma by inducing CXCL13 chemokine production in structural lung cells. PMID: 27639935
  5. the findings of the present study indicated that the noninvasive investigation of urinary CXCL13/Cr may be valuable for the detection of AR, particularly antibodymediated rejection . In addition, high urinary CXCL13/Cr levels predicted a poor response to steroid treatment and compromised graft function PMID: 29956754
  6. CXCL13 seems to be a useful marker of disease activity in systemic lupus erythematosus, but not in cutaneous lupus erythematosus or chronic cutaneous lupus erythematosus. PMID: 29728857
  7. Serum level of CXCL13 is associated with disease activity in systemic lupus erythematosus but does not seem to be a biomarker for arthritis. PMID: 29338586
  8. Serum CXCL13 positivity was found to be associated with oral symptoms, ocular signs and hyperglobulinemia in Asian Indian patients with primary Sjogren's syndrome. PMID: 29541901
  9. we found that CXCL13 indeed has a high sensitivity and specificity for diagnosing LNB, which means that it can be used as a new diagnostic biomarker for the diagnosis of LNB. PMID: 28972436
  10. the elevated concentrations of CXCL13, CXCL8, and CXCL10 or their increasing CSF/serum ratios may be potential biomarkers of neurosyphilis PMID: 27650493
  11. CXCL13 is a highly sensitive and specific CSF marker that helps to differentiate Lyme neuroborreliosis from other central nervous system disorders in children. PMID: 28859668
  12. Study suggested that maternal rs355687 variant in CXCL13 gene was associated with decreased risk of HBV intrauterine infection compared to those with CC genotypes. PMID: 27212637
  13. Elevations in serum MDC and BLC were independently associated with the significant risk of early stage lung adenocarcinoma, even in non-smokers and in stage IA patients. PMID: 27811371
  14. Studied CSF levels of B-lymphocyte Chemoattractant CXCL13 in children with Lyme neuroborreliosis (LNB), and found CSF CXCL13 levels were substantially higher in children with LNB compared with children with other diagnoses. PMID: 28661964
  15. This study indicated that CXCL13 may be pathogenically involved in Clostridium difficile infection (CDI) and served as a potential new biomarker for diagnosis and prognosis in CDI. PMID: 27685937
  16. This study indicated that CXCL13 rather than IL-31 may have clinical values of diagnosis and prognosis in hepatocellular carcinoma. PMID: 27663978
  17. CXCL13/CXCR5 mediated the aggregation of B cells, that directed the aberrant humoral immune responses via the formation of ectopic germinal centers, which suggests a molecular mechanism of neurological damage in neurosyphilis. PMID: 28931218
  18. High CXCL13 expression is associated with B-cell Lymphoma. PMID: 28108506
  19. CCL21 and CXCL13 levels are increased in the minor salivary glands of patients with Sjogren's syndrome. PMID: 27782867
  20. we demonstrate that PKCepsilon cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCe overexpression and Pten loss individually and synergistically upregulate the production of the chemokine CXCL13, which involves the transcriptional activation of the CXCL13 gene PMID: 28402859
  21. During remission, serum CXCL13 and BAFF levels have not decreased to normal in neuromyelitis optica patients, and B-cell-related autoimmune response persists. Immunosuppressive therapy decreased serum BAFF levels, but did not affect CXCL13 expression. PMID: 28413701
  22. This study suggested that increased serum levels of CXCL13 might be involved in renal ectopic lymphoid tissue (ELT)formation and renal impairment process in lupus nephritis. PMID: 27990444
  23. CXCL13 mRNA expression and protein levels were significantly up-regulated in the brain from temporal lobe epilepsy patients. PMID: 27873133
  24. CXCL13 could be a potential biomarker for predicting recurrence in HBV-related hepatocellular carcinoma patients after hepatectomy. PMID: 26517519
  25. was overexpressed in pulmonary vascular lesions of patients with IPAH and CTEPH, and increased serum concentrations were found in patients with IPAH and CTEPH, suggesting a potential pathogenic role of CXCL13 in both diseases. PMID: 26927848
  26. Findings suggest the potential use of chemokine CXCL13 as a plasma biomarker of germinal centers (GCs) activity in vaccine trials and other clinical settings. PMID: 26908875
  27. Aqueous humor concentration of CXCL13 is correlated with subfoveal choroidal thickness in normal subjects. PMID: 26121407
  28. Serum CXCL10 and CXCL13 levels may serve as clinical markers and contribute to the inflammatory response, especially skin manifestations thereof, in adult-onset Still's disease PMID: 26385705
  29. findings reveal a neuronal/astrocytic interaction in the spinal cord by which neuronally produced CXCL13 activates astrocytes via CXCR5 to facilitate neuropathic pain. PMID: 26752644
  30. Gene encoding CXCL13 was identified as being upregulated and found to be negatively correlated with survival over 3-year follow-up period in Idiopathic pulmonary fibrosis. PMID: 26109466
  31. Therefore, CSF CXCL13 concentrations could improve the diagnosis of ANS in HIV-infected patients PMID: 25769888
  32. In the presence of endometriosis, proliferative-phase endometrial expression of CXCL13 markedly increased. PMID: 25031316
  33. CXCL13 and CCL4 could act as circulating biomarkers in autoimmune hemolytic anemia (AIHA), and higher plasma soluble TNFRII might favor the diagnosis of SLE-related instead of primary AIHA. PMID: 25889297
  34. This is the first to indicate the clinical relevance of CXCL13 to young breast cancer and represents a potential therapeutic target for young breast cancer. PMID: 25990390
  35. Findings demonstrate a link between CXCL13 and primary Sjogren's syndrome disease activity and lymphoma. PMID: 26359802
  36. CXCL13 plays an important role in the progression of hepatocellular carcinoma. PMID: 26161394
  37. a direct target of IRF5 resulting in the enhanced recruitment of B and T cells to IRF5-positive tumor-conditioned media PMID: 25533286
  38. CXCL13 might predict survival outcomes in patients with extranodal natural killer (NK)/T-cell lymphoma PMID: 25966773
  39. our findings suggest that CXCL13-CXCR5 axis promotes the growth, migration, and invasion of colon cancer cells, probably via PI3K/AKT pathway PMID: 25476740
  40. CXCL13 up-regulation may be differently linked to the development of primary central nervous system lymphomas and to the accumulation of tumor-infiltrated lymphocytes. PMID: 25433721
  41. marked elevations of serum CXCL13 levels resided nearly completely within the seropositive population of rheumatoid arthritis patients PMID: 24766912
  42. In primary biliary cirrhosis, CXCL13 promotes aggregation of CD19(+) B cells and CXCR5(+) CD4(+) T cells. PMID: 25627620
  43. CSF CXCL13 levels correlated with CSF cell count, total protein, IgG Index and with the presence of CSF IgG and IgM oligoclonal bands. PMID: 26004159
  44. Data indicate that patients with high baseline plasma C-X-C motif chemokine 13 (CXCL13) levels had an improved chance of remission after 2 years. PMID: 25249397
  45. After validation in larger patient groups, CXCR5 and CXCL13 may prove useful as biomarkers for nonsmall cell lung carcinoma Correspondingly, blockade of this axis could serve as an effective therapy for nonsmall cell lung carcinoma. PMID: 25271023
  46. Data show that chemokine CXCL13 production by monocytes required toll-like receptor 7 activation and secretion of interferon-alpha. PMID: 25667414
  47. Myofibroblast activation and CXCL13 expression also occur in the normal prostate after androgen deprivation, and CXCL13 is expressed by myofibroblasts in human prostate cancer. PMID: 25267627
  48. The study confirms the relevance of CXCL13 as a diagnostic biomarker of neuroborreliosis and suggests that CSF CXCL13 in NB is linked to duration of disease PMID: 19965843
  49. overexpressed in myasthenia gravis thymus PMID: 24393484
  50. highly significant stepwise progressive increase in CXCL 13 level was recorded through controls, inactive SLE and active disease (P < 0.01). Moreover, it correlated positively with SLEDAI and proteinuria (P < 0.01). PMID: 25812350

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Subcellular Location
Protein Families
Intercrine alpha (chemokine CxC) family
Tissue Specificity
Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
Database Links

HGNC: 10639

OMIM: 605149

KEGG: hsa:10563

STRING: 9606.ENSP00000286758

UniGene: Hs.100431

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