Recombinant Human C-X-C motif chemokine 13 protein(CXCL13) (Active)

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Code CSB-AP000771HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human B cells is in a concentration range of 1.0-10 ng/ml.
Target Names CXCL13
Uniprot No. O43927
Research Area Immunology
Alternative Names ANGIE; ANGIE2 ; B cell attracting chemokine 1; B cell-attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant ; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); BCA-1; BLC; BLR1L ; C-X-C motif chemokine 13; Chemokine (C-X-C motif) ligand 13 ; Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) ; Chemokine; CXC motif; ligand 13; CXC chemokine BLC; CXCL13; CXL13_HUMAN; SCYB13; Small inducible cytokine B subfamily (Cys-X-Cys motif); member 13 (B-cell chemoattractant); Small inducible cytokine B13; Small inducible cytokine subfamily B; member 13; Small-inducible cytokine B13
Species Homo sapiens (Human)
Source E.coli
Expression Region 23-109aa
Complete Sequence VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP
Mol. Weight 10.3 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Gene References into Functions
  1. CXCL13 is elevated in cerebrospinal fluid in children with Lyme neuroborreliosis. PMID: 30083887
  2. We found a strong association of CXCL13 rs355689*C allele with essential hypertension under additive (OR 0.56, PFDR = 0.008) and dominant (OR 0.41, PFDR 4.38 x 10- 4) genetic model. Our results indicate that CXCL13 rs355689 polymorphism is strongly associated with essential hypertension in the ethnic group of Tatars from Russia. PMID: 30019153
  3. High CXCL13 expression was associated with larger tumor diameter and shorter OS. By multivariate analysis, CXCL13 expression was associated with OS independently from clinicopathological factors. PMID: 29085997
  4. IL-17 enhances the migration of B cells during asthma by inducing CXCL13 chemokine production in structural lung cells. PMID: 27639935
  5. the findings of the present study indicated that the noninvasive investigation of urinary CXCL13/Cr may be valuable for the detection of AR, particularly antibodymediated rejection . In addition, high urinary CXCL13/Cr levels predicted a poor response to steroid treatment and compromised graft function PMID: 29956754
  6. CXCL13 seems to be a useful marker of disease activity in systemic lupus erythematosus, but not in cutaneous lupus erythematosus or chronic cutaneous lupus erythematosus. PMID: 29728857
  7. Serum level of CXCL13 is associated with disease activity in systemic lupus erythematosus but does not seem to be a biomarker for arthritis. PMID: 29338586
  8. Serum CXCL13 positivity was found to be associated with oral symptoms, ocular signs and hyperglobulinemia in Asian Indian patients with primary Sjogren's syndrome. PMID: 29541901
  9. we found that CXCL13 indeed has a high sensitivity and specificity for diagnosing LNB, which means that it can be used as a new diagnostic biomarker for the diagnosis of LNB. PMID: 28972436
  10. the elevated concentrations of CXCL13, CXCL8, and CXCL10 or their increasing CSF/serum ratios may be potential biomarkers of neurosyphilis PMID: 27650493
  11. CXCL13 is a highly sensitive and specific CSF marker that helps to differentiate Lyme neuroborreliosis from other central nervous system disorders in children. PMID: 28859668
  12. Study suggested that maternal rs355687 variant in CXCL13 gene was associated with decreased risk of HBV intrauterine infection compared to those with CC genotypes. PMID: 27212637
  13. Elevations in serum MDC and BLC were independently associated with the significant risk of early stage lung adenocarcinoma, even in non-smokers and in stage IA patients. PMID: 27811371
  14. Studied CSF levels of B-lymphocyte Chemoattractant CXCL13 in children with Lyme neuroborreliosis (LNB), and found CSF CXCL13 levels were substantially higher in children with LNB compared with children with other diagnoses. PMID: 28661964
  15. This study indicated that CXCL13 may be pathogenically involved in Clostridium difficile infection (CDI) and served as a potential new biomarker for diagnosis and prognosis in CDI. PMID: 27685937
  16. This study indicated that CXCL13 rather than IL-31 may have clinical values of diagnosis and prognosis in hepatocellular carcinoma. PMID: 27663978
  17. CXCL13/CXCR5 mediated the aggregation of B cells, that directed the aberrant humoral immune responses via the formation of ectopic germinal centers, which suggests a molecular mechanism of neurological damage in neurosyphilis. PMID: 28931218
  18. High CXCL13 expression is associated with B-cell Lymphoma. PMID: 28108506
  19. CCL21 and CXCL13 levels are increased in the minor salivary glands of patients with Sjogren's syndrome. PMID: 27782867
  20. we demonstrate that PKCepsilon cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCe overexpression and Pten loss individually and synergistically upregulate the production of the chemokine CXCL13, which involves the transcriptional activation of the CXCL13 gene PMID: 28402859
  21. During remission, serum CXCL13 and BAFF levels have not decreased to normal in neuromyelitis optica patients, and B-cell-related autoimmune response persists. Immunosuppressive therapy decreased serum BAFF levels, but did not affect CXCL13 expression. PMID: 28413701
  22. This study suggested that increased serum levels of CXCL13 might be involved in renal ectopic lymphoid tissue (ELT)formation and renal impairment process in lupus nephritis. PMID: 27990444
  23. CXCL13 mRNA expression and protein levels were significantly up-regulated in the brain from temporal lobe epilepsy patients. PMID: 27873133
  24. CXCL13 could be a potential biomarker for predicting recurrence in HBV-related hepatocellular carcinoma patients after hepatectomy. PMID: 26517519
  25. was overexpressed in pulmonary vascular lesions of patients with IPAH and CTEPH, and increased serum concentrations were found in patients with IPAH and CTEPH, suggesting a potential pathogenic role of CXCL13 in both diseases. PMID: 26927848
  26. Findings suggest the potential use of chemokine CXCL13 as a plasma biomarker of germinal centers (GCs) activity in vaccine trials and other clinical settings. PMID: 26908875
  27. Aqueous humor concentration of CXCL13 is correlated with subfoveal choroidal thickness in normal subjects. PMID: 26121407
  28. Serum CXCL10 and CXCL13 levels may serve as clinical markers and contribute to the inflammatory response, especially skin manifestations thereof, in adult-onset Still's disease PMID: 26385705
  29. findings reveal a neuronal/astrocytic interaction in the spinal cord by which neuronally produced CXCL13 activates astrocytes via CXCR5 to facilitate neuropathic pain. PMID: 26752644
  30. Gene encoding CXCL13 was identified as being upregulated and found to be negatively correlated with survival over 3-year follow-up period in Idiopathic pulmonary fibrosis. PMID: 26109466
  31. Therefore, CSF CXCL13 concentrations could improve the diagnosis of ANS in HIV-infected patients PMID: 25769888
  32. In the presence of endometriosis, proliferative-phase endometrial expression of CXCL13 markedly increased. PMID: 25031316
  33. CXCL13 and CCL4 could act as circulating biomarkers in autoimmune hemolytic anemia (AIHA), and higher plasma soluble TNFRII might favor the diagnosis of SLE-related instead of primary AIHA. PMID: 25889297
  34. This is the first to indicate the clinical relevance of CXCL13 to young breast cancer and represents a potential therapeutic target for young breast cancer. PMID: 25990390
  35. Findings demonstrate a link between CXCL13 and primary Sjogren's syndrome disease activity and lymphoma. PMID: 26359802
  36. CXCL13 plays an important role in the progression of hepatocellular carcinoma. PMID: 26161394
  37. a direct target of IRF5 resulting in the enhanced recruitment of B and T cells to IRF5-positive tumor-conditioned media PMID: 25533286
  38. CXCL13 might predict survival outcomes in patients with extranodal natural killer (NK)/T-cell lymphoma PMID: 25966773
  39. our findings suggest that CXCL13-CXCR5 axis promotes the growth, migration, and invasion of colon cancer cells, probably via PI3K/AKT pathway PMID: 25476740
  40. CXCL13 up-regulation may be differently linked to the development of primary central nervous system lymphomas and to the accumulation of tumor-infiltrated lymphocytes. PMID: 25433721
  41. marked elevations of serum CXCL13 levels resided nearly completely within the seropositive population of rheumatoid arthritis patients PMID: 24766912
  42. In primary biliary cirrhosis, CXCL13 promotes aggregation of CD19(+) B cells and CXCR5(+) CD4(+) T cells. PMID: 25627620
  43. CSF CXCL13 levels correlated with CSF cell count, total protein, IgG Index and with the presence of CSF IgG and IgM oligoclonal bands. PMID: 26004159
  44. Data indicate that patients with high baseline plasma C-X-C motif chemokine 13 (CXCL13) levels had an improved chance of remission after 2 years. PMID: 25249397
  45. After validation in larger patient groups, CXCR5 and CXCL13 may prove useful as biomarkers for nonsmall cell lung carcinoma Correspondingly, blockade of this axis could serve as an effective therapy for nonsmall cell lung carcinoma. PMID: 25271023
  46. Data show that chemokine CXCL13 production by monocytes required toll-like receptor 7 activation and secretion of interferon-alpha. PMID: 25667414
  47. Myofibroblast activation and CXCL13 expression also occur in the normal prostate after androgen deprivation, and CXCL13 is expressed by myofibroblasts in human prostate cancer. PMID: 25267627
  48. The study confirms the relevance of CXCL13 as a diagnostic biomarker of neuroborreliosis and suggests that CSF CXCL13 in NB is linked to duration of disease PMID: 19965843
  49. overexpressed in myasthenia gravis thymus PMID: 24393484
  50. highly significant stepwise progressive increase in CXCL 13 level was recorded through controls, inactive SLE and active disease (P < 0.01). Moreover, it correlated positively with SLEDAI and proteinuria (P < 0.01). PMID: 25812350
  51. three SNPs (rs497916, rs3922, rs676925) in CXCR5 and one SNP (rs355687) in CXCL13 were associated with hepatitis B vaccine efficacy PMID: 25077417
  52. Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer PMID: 25010623
  53. MMP3 and CXCL13 are systemic biomarkers that reflect the aggregate burden of these pathological features across total lung tissue. PMID: 25217476
  54. Synovial CXCL13 appears to be a marker of a more severe pattern of rheumatoid arthritis disease, characterized by increased lymphocyte activation and bone remodelling beyond the level of conventional markers of inflammation. PMID: 24764267
  55. Suggest that platelet-mediated signaling through CXCR5 may be active in vivo during plaque destabilization, enhancing the anti-inflammatory effects of CXCL13. PMID: 24732574
  56. CXCL13 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
  57. the CXCL13 concentration was significantly This study demonistrated that elevated in the CSF of the group with aseptic meningoencephalitis compared with the group with aseptic meningitis. PMID: 24907903
  58. CXCL13 stimulated epithelial to mesenchymal transition and matrix metalloproteinase-9 expression via RANKL-Src axis in breast cancer cell lines. PMID: 24337540
  59. CXCL13 is increased and is a prognostic biomarker in patients with Idiopathic Pulm Fibrosis (IPF), and more so than in patients with COPD. This contrast indicates CXCL13 overexpressions are intrinsic to IPF, rather than an epiphenomenon of lung injury. PMID: 24628285
  60. The Blc appeared to be not fully compatible with our approach, owing to problems with refolding of the hybrid constructs, loop-grafted versions of OmpA delivered encouraging results PMID: 23109547
  61. CXCL13 correlated with CSF WBC in neuromyelitis optica, the IgG index in multiple sclerosis and serum CXCL13 was elevated in neuromyelitis optica. PMID: 23322500
  62. we found correlations between high mean levels of CXCL13 in the CSF and some of the genotypes that are associated with an increased risk of multiple sclerosis PMID: 23175382
  63. CXCL13 may be pathogenically involved in SS and may serve as a new marker and a potential therapeutic target. PMID: 23904442
  64. The CXCL13 and IL21 expression is pivotal for the T-helper/B cell axis correlating with survival. PMID: 24138885
  65. CXCL13 is expressed in an age-dependent manner in both adult mouse and human hepatic macrophages during hepatitis B infection. PMID: 23925290
  66. CXCL13, MMP-3 and TIMP-1 distinguish active ANCA-associated vasculitis from remission better than the other markers studied, including ESR and CRP. PMID: 22975753
  67. Elevated CXCL13 expression is associated with central nervous system lymphomas. PMID: 23570798
  68. Increased serum CXCL13 levels are associated with HIV-associated non-hodgkin B-cell lymphoma. PMID: 23250934
  69. Elevated CSF CXCL13 levels reflect a strong humoral immune response and cell recruitment to the central nervous system compartment during neuroinflammation. PMID: 22591862
  70. Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection. PMID: 23189125
  71. Data indicate that EBI2 expression modulates CXCL13 binding affinity to CXCR5. PMID: 22913878
  72. c-Myc activation through CXCL13-CXCR5 signaling axis stimulates RANKL expression in stromal/preosteoblast cells. Thus, our results implicate CXCL13 as a potential therapeutic target to prevent OSCC invasion of bone/osteolysis PMID: 22330139
  73. Levels of CXCL13 are increased in carotid atherosclerosis both systemically and within the atherosclerotic lesion. Based on our in vitro findings, we hypothesize a potential plaque stabilizing effects of CXCL13-CXCR5 interaction PMID: 22840692
  74. findings show decidual stromal cells and follicular dendritic cells shared some of each other's distinctive features such as expression of B cell-activating factor, C-X-C motif chemokine 13 secretion and the capacity to rescue B cells from apoptosis PMID: 22718279
  75. Data show that the mean CXCL13 concentration in sera from Sjogren's patients was 170 pg/ml, compared to 92.0 pg/ml for sera from healthy controls. PMID: 22044682
  76. Elevated sCXCL13 levels were detected up to 2 years prior to PTLD diagnosis and correlated well with response to cytoreductive treatment in individual patients. sCXCL13, thus, may be a readily available surrogate marker for the diagnosis of PTLD PMID: 22335599
  77. The CXCL13-CXCR5 axis is associated with classic determinants of poor prognosis, such as high grade, hormone receptor negativity, and axillary node involvement. PMID: 22607768
  78. Expression of CXCL13 is significantly increased in types B1 and B2 thymoma patients with generalized myasthenia gravis, compared to those with ocular myasthenia gravis. PMID: 22000402
  79. CXCL10, CXCL11, CXCL12 and CXCL13 chemokines are biomarkers in serum and cerebrospinal fluid in patients with tick borne encephalitis PMID: 22008312
  80. CXCL13 serum levels show great variance even in the healthy population and are not indicative of active neuroborreliosis. PMID: 21320077
  81. Neuromyelitis optica patients with higher relapse rates exhibit higher CXCL13 concentrations in their cerebrospinal fluid (CSF) as well as a trend of increased disease disability with increased CSF CXCL13 levels. PMID: 22036953
  82. CXCL10 and CXCL13 Expression were highly up-regulated in peripheral blood mononuclear cells in acute rejection and poor response to anti-rejection therapy. PMID: 21191639
  83. these results add new information about the CXCL13-CXCR5 axis in neuroblastic tumors and in the crosstalk between neuroblastic and stromal cells. PMID: 21642390
  84. Data indicate that an increased level of CXCL13 is a feature of systemic lupus erythematosus that correlates with disease activity and severity. PMID: 21576203
  85. BAFF/CXCL12 may work in concert to affect B-cell homeostasis in multiple sclerosis and contribute to the pathophysiology of the disease. PMID: 21372118
  86. Our results show CXCL13-mediated PCa cell invasion requires Akt and ERK12 activation and suggests a new role for DOCK2 in proliferation of hormone-refractory CXCR5-positive PCa cells. PMID: 21645150
  87. stable serum marker for disease activity in systemic lupus erythematosus patients, but concomitant infections can also lead to increased CXCL13 levels PMID: 21078761
  88. Our findings indicate that CXCL13 is a novel serologic marker predictive of rheumatoid arthritis severity. PMID: 21305530
  89. Data show negative correlations for BAFF concentration vs blood B cell percentage and serum CXCL13 concentration. PMID: 21211990
  90. CXCL13 was associated with disease exacerbations and unfavourable prognosis in relapsing-remitting multiple sclerosis. PMID: 21135023
  91. Expressions of CXCL13, CD10 and bcl-6 were significantly higher in angioimmunoblastic T-cell lymphoma patients than in peripheral T-cell lymphoma patients. PMID: 19575892
  92. found enhanced plasma levels of CXCL13 in patients suffering from type IV lupus nephritis PMID: 21084753
  93. Aberrant expression of selectin E, CXCL1, and CXCL13 occurs in chronic endometritis. PMID: 20495539
  94. CXCL13 caused CXCR5-dependent activation of the PI3Kp85alpha in prostate cancer cells PMID: 20412587
  95. Human neural precursor cells express the CXCL13 receptor and migrate across brain endothelial cells in response to CXCL13 expression. PMID: 20400187
  96. elevated production is correlated with systemic lupus erythematosus disease activity PMID: 19774453
  97. expression up-regulated in polyp tissue of chronic rhinosinusitis PMID: 20109310
  98. Both protein and mRNA of CXCL13 and CXC chemokine receptor 5 (CXCR5) in the thymic tissues were significantly higher in MG patients with lymphoid hyperplasia than those with thymoma. PMID: 20223524
  99. data implicate a functional role for CXCL13 in oral squamous cell carcinoma (OSCC) tumor invasion into bone and may be a potential therapeutic target to prevent osteolysis associated with OSCC tumors in vivo PMID: 19816883
  100. Results suggest that BLC/CXCL13 as well as its corresponding receptor, CXCR5, may play important roles in the pathogenesis of SLE and in lupus nephritis. PMID: 19955043

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Subcellular Location Secreted
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
Database Links

HGNC: 10639

OMIM: 605149

KEGG: hsa:10563

STRING: 9606.ENSP00000286758

UniGene: Hs.100431

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