Code | CSB-AP000771HU |
MSDS | |
Size | $142 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
The Recombinant Human CXCL13 protein is a valuable research tool for investigators working in the field of immunology. This C-X-C motif chemokine 13, known by its aliases CXCL13, BCA1, BLC, and SCYB13, is expressed in E. coli and spans the 23-109aa region, including the full length of the mature protein. Offered as a tag-free, lyophilized powder, this protein can be readily reconstituted with sterile water or an appropriate buffer to accommodate a range of experimental requirements.
Our Recombinant Human CXCL13 protein showcases a high purity of >97%, as established by both SDS-PAGE and HPLC analyses. The endotoxin levels are carefully controlled, ensuring they remain below 1.0 EU/µg, as confirmed by the LAL method. The protein is fully biologically active when compared to standard, with its biological activity determined by a chemotaxis bioassay using human B cells within a concentration range of 1.0-10 ng/ml.
Throughout the years, various studies have highlighted the significance of CXCL13 in immunology research. For instance, Ansel et al. (2000)[1] explored the role of CXCL13 in organizing B cell follicles in secondary lymphoid tissues. Additionally, Allen et al. (2004)[2] demonstrated the involvement of CXCL13 in regulating the homeostatic trafficking of B and T cells. More recently, Förster et al. (2021)[3] investigated the potential of CXCL13 as a biomarker in inflammatory diseases, illustrating the importance of CXCL13 in understanding immune system function and potential therapeutic applications in immune-related disorders.
References:
1. Ansel KM, et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000;406(6793):309-14.
2. Allen CD, et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004;5(9):943-52.
3. Förster Y, et al. CXCL13: A novel biomarker for inflammation? Int J Mol Sci. 2021;22(11):6039.
There are currently no reviews for this product.